2/2 APOL1 Long-Term Kidney Transplantation Outcomes Network- Clinical Center

2/2 APOL1 长期肾移植结果网络-临床中心

• 批准号: 9974999
• 负责人: Sumit Mohan
• 金额: $ 34.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974999
• 关键词: AIDS-Associated Nephropathy; Academic Medical Centers; Address; Adult; Affect; African; African American; Allografting; Anxiety; Apolipoproteins; Censuses; Childhood; Clinical; Collaborations; Collection; Data; Donor person; End stage renal failure; Enrollment; Epidemiology; Ethics; Failure; Focal Segmental Glomerulosclerosis; Genes; Genetic; Genetic study; Genomics; Genotype; Heterozygote; High Prevalence; Hispanics; Immunology; Individual; Inferior; Information Systems; Kidney; Kidney Diseases; Kidney Transplantation; Latino; Link; Living Donors; Minority; Multicenter Studies; Natural Selections; Organ; Organ Procurements; Outcome; Outcomes Research; Patients; Penetrance; Pennsylvania; Population; Race; Recording of previous events; Research; Research Personnel; Retrospective cohort study; Risk; Scientist; Standardization; System; Testing; Transplant Recipients; Transplantation; Trypanosomiasis; United Network for Organ Sharing; United States; Universities; clinical center; design; experience; follow-up; gene interaction; genetic variant; high risk; innovation; living kidney donor; member; multidisciplinary; non-diabetic; novel; organ procurement transplantation network; programs; prospective; psychosocial; racial disparity; recruit; risk variant; success; transplant centers

Project Summary (Abstract) The Columbia-Penn Clinical Consortium (CPCC) brings together an experienced multidisciplinary team of clinical and basic scientist investigators at Columbia University Medical Center and University of Pennsylvania Transplant Programs. The CPCC investigators have expertise in the fields of transplant epidemiology, immunology, genetics and ethics, as well as an extensive history of collaboration with the United Network for Organ Sharing (UNOS) and other CPCC member transplant programs. As a result, the CPCC is well suited to recruit and retain patients for longitudinal follow up for the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO). This proposed Clinical Center will comprise of 26 pediatric and adult large, medium and small size transplant centers and 9 organ procurement organizations predominantly in four contiguous states (NY, NJ, CT and PA) in the northeast US. Our primary objective is to enroll all donors of African ancestry (e.g. African-Americans and Black Hispanic) and their recipients within the consortium for genetic and genomic studies by the APOLLO Network (Aim 1). We will follow all recruited donor-recipient pairs with longitudinal collection of biospecimens and clinical outcomes along with pragmatic integration with Organ Procurement and Transplantation Network (OPTN), UNOS and the United States Renal Data System (USRDS) data (Aim 2). Our experience in the recruitment and retention of minority patients in multicenter studies, as well as the use of innovative analytics with linkage to UNOS, USRDS and other geospatial data, will be of benefit to the APOLLO Network. We expect that our unique design and implementation expertise to the APOLLO study will address the hypothesis that the presence of two APOL1 risk variants is associated with inferior allograft outcomes following kidney transplant and increases the risk of adverse renal outcomes for affected living donors.

项目概要（摘要） 哥伦比亚-宾夕法尼亚大学临床联盟 (CPCC) 汇集了一支经验丰富的多学科团队 哥伦比亚大学医学中心和宾夕法尼亚大学的临床和基础科学家研究人员 移植计划。 CPCC 调查人员拥有移植流行病学领域的专业知识、 免疫学、遗传学和伦理学，以及与联合网络的广泛合作历史 器官共享（UNOS）和其他 CPCC 成员移植计划。因此，CPCC 非常适合 招募并留住患者进行 APOL1 长期肾移植结果的纵向随访 研究网络（阿波罗）。该拟建临床中心将由 26 个儿科和成人大型、 中小型移植中心和9家器官获取机构，主要集中在4个地区 美国东北部邻近的州（纽约州、新泽西州、康涅狄格州和宾夕法尼亚州）。我们的主要目标是招募所有捐助者 非洲血统（例如非洲裔美国人和黑人西班牙裔）及其在财团内的接受者 APOLLO 网络的遗传和基因组研究（目标 1）。我们将跟踪所有招募的捐赠者-接受者对 纵向收集生物样本和临床结果以及与器官的务实整合 采购和移植网络 (OPTN)、UNOS 和美国肾脏数据系统 (USRDS) 数据（目标 2）。我们在多中心招募和保留少数族裔患者方面的经验 研究以及与 UNOS、USRDS 和其他地理空间数据相联系的创新分析的使用，将 对 APOLLO 网络有益。我们期望我们独特的设计和实施专业知识能够 APOLLO 研究将解决以下假设：两个 APOL1 风险变异的存在与 肾移植后的同种异体移植结果较差，并增加了不良肾脏结果的风险 受影响的活体捐赠者。