From Phenotype to Mechanism: Mapping the Pathways underlying Risky Choice

从表型到机制：绘制风险选择背后的路径

• 批准号: 7941885
• 负责人: SCOTT Allen HUETTEL
• 金额: $ 49.69万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941885
• 关键词: Accounting; Address; Adolescent; Adopted; Adult; Age; Anxiety; Area; Attitude; Behavior; Behavioral; Biological Markers; Brain; Candidate Disease Gene; Categories; Child; Client; Cognitive; Collaborations; Complex; Data; Data Collection; Decision Making; Depressed mood; Development; Discipline; Disease; Economics; Elements; Faculty; Fright; Functional Magnetic Resonance Imaging; Funding; Genetic; Genomics; Genotype; Helmet; Home environment; Image; Individual; Individual Differences; Knowledge; Left; Longevity; Maps; Measures; Mental Depression; Mental disorders; Methods; National Institute of Mental Health; Neurosciences; Neurosciences Research; Outcome; Pathology; Pathway interactions; Pattern; Phenotype; Plant Roots; Play; Polymorphism Analysis; Preparation; Procedures; Process; Psyche structure; Psychology; Research; Research Infrastructure; Research Methodology; Resistance; Retirement; Rewards; Risk; Role; Sampling; Schizophrenia; Scholarship; Science; Sociology; Staging; System; Testing; Validation; Work; cognitive neuroscience; design; genome sequencing; genome wide association study; insight; neuroimaging; neuromechanism; novel; physical conditioning; preference; relating to nervous system; research study; response; theories

DESCRIPTION (provided by applicant): This application addresses Broad Challenge Area (03) Biomarker, Discovery and Validation, with specific Challenge Topic, 03-MH-101, Biomarkers in Mental Disorders. We propose to leverage an ongoing collaboration among faculty from several disciplines to identify individual differences in risky decision making and to map biomarkers of those individual differences. Maladaptive decisions when faced with risk are hallmarks of many disorders, including depression, schizophrenia, and anxiety. We adopt a mechanistic research framework that risk-seeking behavior reflects, not one phenotype, but distinct effects of risk information upon multiple brain systems, each with potentially independent genetic contributions. Experiments aggressively integrate cutting- edge methods -- behavioral economics, individual difference neuroimaging, developmental cognitive neuroscience, and genome sequencing -- to determine why some people make risky decisions and others do not. Our project builds upon extensive preliminary data, validated research methods, a collaborative research team, and a substantial research infrastructure. By integrating these methods, we will identify biologically predictive markers of risky decision making that cut across clinically-defined categories of mental disorders. Adaptive decision making, especially under risk, is critical for mental and physical health. This project will identify biomarkers, both neural and genomic, for individual differences in the processes that underlie risky decision making. Mapping these processes will provide important and novel insight into mental health disorders notable for pathologies of decision making.

描述（由申请人提供）：本申请涉及广泛的挑战领域 (03) 生物标志物、发现和验证，以及具体的挑战主题 03-MH-101，精神障碍中的生物标志物。我们建议利用多个学科的教师之间的持续合作来识别风险决策中的个体差异，并绘制这些个体差异的生物标志物。面临风险时做出的适应不良决策是许多疾病的标志，包括抑郁症、精神分裂症和焦虑症。我们采用了一种机制研究框架，即风险寻求行为反映的不是一种表型，而是风险信息对多个大脑系统的独特影响，每个系统都有潜在的独立遗传贡献。实验积极整合前沿方法——行为经济学、个体差异神经影像学、发育认知神经科学和基因组测序——来确定为什么有些人会做出危险的决定，而另一些人则不会。我们的项目建立在广泛的初步数据、经过验证的研究方法、协作研究团队和大量的研究基础设施的基础上。通过整合这些方法，我们将识别跨临床定义的精神障碍类别的风险决策的生物预测标记。适应性决策，尤其是在面临风险的情况下，对于身心健康至关重要。该项目将识别神经和基因组生物标志物，以识别风险决策过程中的个体差异。绘制这些过程将为了解以决策病理学为特征的精神健康障碍提供重要而新颖的见解。

项目成果

Strategic control in decision-making under uncertainty.

• DOI: 10.1111/j.1460-9568.2012.08009.x
• 发表时间: 2012-04
• 期刊: The European journal of neuroscience
• 作者: Venkatraman V;Huettel SA
• 通讯作者: Huettel SA

Synchrony between sensory and cognitive networks is associated with subclinical variation in autistic traits.

• DOI: 10.3389/fnhum.2015.00146
• 发表时间: 2015
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9
• 作者: Young JS;Smith DV;Coutlee CG;Huettel SA
• 通讯作者: Huettel SA

Seasonal variation of salivary testosterone in men, normally cycling women, and women using hormonal contraceptives.

男性、正常骑自行车的女性和使用激素避孕药的女性唾液睾酮的季节性变化。

• DOI: 10.1016/j.physbeh.2011.07.009
• 发表时间: 2011
• 期刊: Physiology & behavior
• 影响因子: 2.9
• 作者: Stanton,StevenJ;Mullette-Gillman,O'DhanielA;Huettel,ScottA
• 通讯作者: Huettel,ScottA

Neurocognitive development of risk aversion from early childhood to adulthood.

从幼儿期到成年期风险厌恶的神经认知发展。

• DOI: 10.3389/fnhum.2011.00178
• 发表时间: 2011
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9
• 作者: Paulsen,DavidJ;Carter,RMcKell;Platt,MichaelL;Huettel,ScottA;Brannon,ElizabethM
• 通讯作者: Brannon,ElizabethM