Mechanisms Regulating Complex Social Behavior

调节复杂社会行为的机制

• 批准号: 10305918
• 负责人: SCOTT Allen HUETTEL
• 金额: $ 79.01万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-20 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10305918
• 关键词: Adherence; Adopted; Anxiety; Behavior; Behavior Control; Behavioral; Brain; Complex; Computer Models; Data; Decision Making; Dehumanization; Disadvantaged; Discrimination; Disease; Effectiveness; Electrophysiology (science); Elements; Environment; Grant; HIV; HIV Seropositivity; Health; Homologous Gene; Human; Individual; Individual Differences; Link; Mediating; Mental Depression; Mental Health; Modeling; Monkeys; Outcome; Parietal; Play; Positioning Attribute; Prefrontal Cortex; Primates; Process; Property; Role; Schizophrenia; Shapes; Social Behavior; Social Controls; Social Environment; Social Functioning; Social Hierarchy; Social Perception; Social status; Structure of superior temporal sulcus; Support System; Techniques; Testing; Time; Treatment Protocols; Work; experimental study; flexibility; health disparity; improved; microstimulation; neural model; neuroimaging; neuropsychiatric disorder; nonhuman primate; novel; relating to nervous system; social; social group; social situation; social skills; theories

Project Summary Social connections among individuals shape many health outcomes. The progression and treatment of a wide range of neuropsychiatric disorders (e.g., schizophrenia) and disease states (e.g., HIV positivity) depend on individuals' social functioning. As examples, social support systems improve adherence to difficult treatment regimens, whereas dysfunctional social perception exacerbates the mental health challenges of depression and anxiety. Work from our groups in the previous period of support provided evidence for a two-stage model that separated the neural and computational processes that establish a social context from those that guide subsequent social control. Here, we test the hypothesis that these processes reflect the core elements necessary for social competence—how one matches behavior to the current demands of the social environment. Social competence has been recently advanced as a consilient, cross-species framework that explains adaptive decision making in social situations. Moreover, perceived deficits in social competence can drive privilege, ostracism, and systemic discrimination—each of which reinforces larger-scale health disparities. In this project, we will determine how status in a social hierarchy influences mechanisms of decision making, manipulate sensitivity to social hierarchies, and determine how the complexity of the social environment changes decision processes. Our three aims rely on tightly integrated and theoretically well-motivated experiments that use primate electrophysiology, human electrophysiology and neuroimaging, and manipulations of brain function; that adopt parallel tasks and social context manipulations; and that analyze behavior through common computational models. Our work builds on progress from the previous grant cycle that demonstrates how our groups are uniquely positioned to achieve these aims.

项目摘要 个人之间的社会联系塑造了许多健康成果。的进展和处理 多种神经精神疾病（例如精神分裂症）和疾病状态（例如，HIV积极性） 取决于个人的社会功能。作为示例，社会支持系统提高了对 困难的治疗方案，而功能失调的社会感知加剧了心理健康 抑郁和焦虑的挑战。在上一个支持的阶段，我们小组的工作 两阶段模型的证据，该模型分离了建立的神经和计算过程 那些指导后续社会控制的社会环境。在这里，我们检验了以下假设 这些过程反映了社会能力所需的核心要素 - 一个人如何匹配 对社会环境当前需求的行为。社会能力最近 作为一个一致的跨物种框架，该框架解释了社会的自适应决策 情况。此外，在社会能力方面的辩护可以推动特权，排斥和 系统性歧视 - 每个人都会增强更大范围的健康差异。在这个项目中，我们将 确定社会层次结构中的地位如何影响决策的机制，操纵 对社会等级制度的敏感性，并确定社会环境的复杂性如何变化 决策过程。我们的三个目标依赖于紧密整合和理论上的良好动机 使用灵长类动物生理学，人类电生理学和神经影像学的实验，以及 操纵大脑功能；采用平行任务和​​社会环境操纵；那 通过通用计算模型分析行为。我们的工作以从 以前的赠款周期表明了我们的团体如何独特地定位以实现这些目标。