High Spatial Resolution Structured Plastic Scintillator

高空间分辨率结构化塑料闪烁体

基本信息

批准号：
7781370
负责人：
VIVEK V NAGARKAR
金额：
$ 61.49万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-22 至 2012-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7781370
关键词：
Acquired Immunodeficiency Syndrome Address Advanced Development Area Arts Bioenergetics Biological Biological Process Biology Blood capillaries Boron Caliber Catalysis Cell Nucleus Cells Charge Chemicals Collaborations Collection Communities Complement Coupled Coupling Crystallography Data Analyses Detection Deuterium Development Devices Diagnostic radiologic examination Diffuse Discrimination Doctor of Philosophy Dyes Electrons Elements Engineering Ensure Enzymatic Biochemistry Evaluation Event Fast Neutrons Feedback Foundations Funding Gadolinium Gamma Rays Glare Glass Goals Government Grant Growth Hawaii Heart Diseases Hydrogen Image Injection of therapeutic agent Institution Intellectual Property Investigation Isotopes Joints Journals Knowledge Laboratories Lateral Lead Legal patent Letters Ligands Light Liquid substance Logistics Marketing Maryland Massachusetts Measurement Medical Medical Imaging Methods Modification Molecular National Security Nature Neutron Diffraction Neutrons Noise Output Paper Peer Review Performance Persons Pharmaceutical Preparations Phase Phase I Clinical Trials Photons Physiologic pulse Plastics Play Polishes Polymers Positioning Attribute Process Production Property Proteins Protocols documentation Protons Publications Radiation Refractive Indices Reporting Research Research Personnel Residual state Resolution Roentgen Rays Role Saints Sampling Science Scientist Security Signal Transduction Silicon Source Specimen Spectrum Analysis Staging Stress Structure Suspension substance Suspensions System Techniques Technology Tennessee Testing Thick Time Universities Vendor Water Work X ray diffraction analysis X-Ray Crystallography X-Ray Diffraction absorption base cancer therapy capillary carborane charge coupled device camera commercialization cost design detector digital electron density functional genomics imaging detector improved instrumentation interest laboratory facility light emission luminescence macromolecule meetings monomer nanoparticle nanosecond next generation novel photomultiplier physical property polymerization practical application programs protein function protein structure protein structure function prototype public health relevance research and development research study response sensor simulation structural biology success symposium

项目摘要

DESCRIPTION (provided by applicant): Neutron techniques complement X-ray diffraction techniques in their ability to precisely locate hydrogen and light atoms in various materials. This information is critical for determining the structure and function of proteins and for the discovery of biological processes taking place on a sub-molecular level, the knowledge of which is necessary in the fields of enzymology, functional genomics, bioenergetics, and structural biology. The advent of high flux pulsed neutron sources and portable laboratory sources will allow researchers to use this unique probe for detailed functional studies of biological matter. Unfortunately, however, the current state of the art area detector technology has significant performance limitations in terms of sensitivity, position resolution, and count rate capability, logistic complications, or non-real-time output. Relatively new digital readout technologies have potential to overcome many of these limitations, but unfortunately they are limited by the current neutron-sensitive scintillator technology. Current scintillators are associated with a tradeoff between detection efficiency and spatial resolution; have low discrimination between neutron and 3-ray events, and are slow in response. The development of new scintillators that overcome these difficulties and provide enhanced signal-to-noise ratios will result in improved detectors that will play a vital role in the effective utilization of neutron sources to facilitate important discoveries. We propose to address limitations of the current neutron scintillator technology by developing a large area, low cost, structured scintillator that can simultaneously provide very high spatial resolution, high detection efficiency, low sensitivity to gamma radiation, and fast temporal response. Furthermore, structured nature of the proposed scintillator will minimize lateral spread of scintillation light, thereby providing images with superior contrast. The novel scintillator thus developed will be integrated into the current digital readouts to demonstrate fabrication of detectors that will fulfill the demanding needs of the current and planned experiments at various institutions around the globe by conducting tests at such national laboratories as ORNL and NIST. The commercialization efforts will be undertaken in collaboration with an industrial partner who has well established production capabilities and marketing groups around the globe.

描述（由申请人提供）：中子技术补充了X射线衍射技术，可以精确定位各种材料中的氢和光原子。该信息对于确定蛋白质的结构和功能至关重要，对于在亚分子级上发生的生物过程的发现，这在酶学，功能基因组学，生物能学和结构生物学领域中必不可少。高通量脉冲中子源和便携式实验室来源的出现将使研究人员能够使用此独特的探测器来详细介绍生物学物质的功能研究。但是，不幸的是，在敏感性，位置分辨率和计数率能力，逻辑并发症或非实时时间输出方面，最先进的区域检测器技术的当前状态具有重大的性能限制。相对较新的数字读数技术有可能克服许多此类局限性，但不幸的是，它们受到当前中子敏感的闪光器技术的限制。当前的闪光灯与检测效率和空间分辨率之间的权衡相关。中子和3射线事件之间的歧视较低，并且响应缓慢。克服这些困难并提供增强的信噪比的新闪烁体的发展将导致改进的检测器，这将在有效利用中子源以促进重要发现中起着至关重要的作用。我们建议通过开发大面积，低成本，结构化的闪烁体来解决当前中子闪烁体技术的局限性，该闪烁体可以同时提供很高的空间分辨率，高检测效率，对伽马射线的低敏感性和快速的时间响应。此外，所提出的闪光灯的结构化性质将最大程度地减少闪烁光的侧向扩散，从而提供具有较高对比度的图像。因此，开发的新型闪光灯将集成到当前的数字读数中，以证明探测器的制造，这些探测器将通过在ORNL和NIST等国家实验室进行测试，以满足全球各个机构的当前和计划实验的苛刻需求。商业化工作将与在全球拥有良好生产能力和营销团体建立的工业合作伙伴合作进行。