BIOMEDICAL (BASIC)

生物医学（基础）

• 批准号: 7939226
• 负责人: DAVID C GOFF
• 金额: $ 144.06万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-14 至 2018-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939226
• 关键词: BIOMEDICAL; BASIC

The major objectives of the SPRINT initiative are to: 1. determine whether treating SBP to a lower goal than currently recommended wil reduce CVD; 2. determine, in the stage 3 CKD subgroup, whether the intensive intervention wil reduce CVD and reduce the progression of renal disease; 3. determine the relative impact of the 2 treatment strategies on quality of life; 4. compare the relative cost effectiveness of the 2 treatment strategies; 5. determine whether the intensive intervention wil reduce the rate of age-related cognitive impairment; 6. determine, in a subset, whether the intensive intervention wil reduce the rate of age-related cognitive impairment ($PRINT~MIND). A second objective is to perform MRI imaging on a subset of the 2,800 participants in the SPRINT-MIND substudy. A third objective is to screen all 7,500 SPRINT participants annually in order to diagnose probable dementia (SPRINT-MIND); and 7. perform DNA extraction and analysis for investigation of relevant pathway genes, genome-wide association, and sequencing in order to define the full spectrum of variants functionally responsible for differences in hypertension risk and related events due to relative levels of BP control. The major objectives of the SPRINT-MIND Substudy are as follows: 1. Cognitive functioning: To determine whether the intensive intervention wil reduce the incidence of cognitive decline and incidence of probable dementia; 2. Imaging: To determine whether the intensive intervention wil reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume; and 3. Diagnosis of probable dementia: To screen all 7,500 participants annually for probable dementia. The objective of this proposal is to create a clinical network to recruit 1,700 SPRINT participants.

Sprint倡议的主要目标是：1。确定将SBP的目标与当前推荐的较低的目标降低了CVD； 2。确定，在第3阶段CKD亚组中，强化干预是否会减少CVD并减少肾脏疾病的进展； 3。确定两种治疗策略对生活质量的相对影响； 4。比较两种治疗策略的相对成本效益； 5。确定强化干预是否会降低与年龄相关的认知障碍的速度； 6.在子集中确定强化干预是否会降低与年龄相关的认知障碍的速度（$ print〜Mind）。第二个目标是在Sprint-Inderdy的2,800名参与者的子集上进行MRI成像。第三个目标是每年筛选所有7,500名Sprint参与者，以诊断可能的痴呆症（Sprint-Mind）；和7。进行DNA提取和分析，以研究相关途径基因，全基因组关联和测序，以定义由于BP对照的相对水平而导致的高血压风险和相关事件的差异在功能上负责。 Sprint-Mind子类的主要目标如下：1。认知功能：确定密集的干预是否会降低发生率 认知能力下降和可能的痴呆症发生率； 2。成像：确定强化干预是否会降低结构中枢神经系统异常的发生率 与血管痴呆以及总脑量下降有关；和3。可能的痴呆症的诊断：每年筛查所有7,500名参与者的痴呆症。该建议的目的是建立一个临床网络，以招募1,700名Sprint参与者。