HELP PREVENT DIABETES

帮助预防糖尿病

• 批准号: 7951389
• 负责人: DAVID C GOFF
• 金额: $ 55.09万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951389
• 关键词: Area; Body Weight decreased; Cardiovascular system; Chronic Disease; Clinical Research; Clinical Trials Design; Communities; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diet; Dietary intake; Eating; Educational Intervention; Funding; Grant; Health; Health Benefit; Health Promotion; Hypertension; Individual; Institution; Intervention; Knowledge; Life Style; Maintenance; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Phase; Physical activity; Prevention; Professional counselor; Public Health; Randomized Controlled Clinical Trials; Research; Research Personnel; Resources; Societies; Source; Testing; Translating; United States National Institutes of Health; Upper arm; Weight; base; cancer prevention; cost; cost effectiveness; diabetes prevention program; economic evaluation; fasting glucose; lifestyle intervention; prevent; primary outcome; programs; secondary outcome; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While trials such as the Diabetes Prevention Program have demonstrated a significant potential for type 2 diabetes mellitus (DM) prevention through lifestyle interventions, a critical knowledge gap is whether such approaches can be implemented in the community. This study is a 300-participant randomized trial designed to test the hypothesis that a lifestyle intervention administered through a community-based diabetes prevention program will have a beneficial and clinically meaningful impact on: fasting glucose (primary outcome), physical activity, dietary intake, weight, and waist circumference (secondary outcomes), and other tertiary outcomes. An economic evaluation will be conducted to determine cost effectiveness. One trial arm will consist of a group-based intensive lifestyle intervention promoting healthy eating, increased physical activity and modest, yet achievable (5-7%) weight loss delivered in an early 6-month intensive phase followed by an 18-month maintenance phase. Lay Health Counselors (LHCs) will be utilized in the intensive intervention arm. The control arm will consist of an individual educational intervention that incorporates existing community resources that are available to assist residents in making healthier lifestyle choices. If the intensive intervention approach is cost-effective, this model can be disseminated to the thousands of U.S. communities with DEPs. Many chronic diseases are influenced by activity and diet. Our lifestyle intervention, if successful, should translate into public health benefits in areas other than type 2 DM, such as obesity, hypertension, cardiovascular health and cancer prevention, thus greatly multiplying the potential benefits for society and serving as a model for community-based health promotion programs.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 虽然糖尿病预防计划等试验已经证明通过生活方式干预预防 2 型糖尿病 (DM) 具有巨大潜力，但关键的知识差距是这些方法是否可以在社区实施。这项研究是一项 300 名参与者的随机试验，旨在检验以下假设：通过基于社区的糖尿病预防计划实施的生活方式干预将对以下方面产生有益且具有临床意义的影响：空腹血糖（主要结果）、体力活动、饮食摄入、体重、腰围（次要结果）和其他三级结果。将进行经济评估以确定成本效益。其中一个试验组将包括基于小组的强化生活方式干预，促进健康饮食、增加体力活动以及在早期 6 个月的强化阶段中实现适度但可实现的 (5-7%) 减肥，随后是 18 个月的维持阶段。非专业健康顾问 (LHC) 将在强化干预部门中发挥作用。控制臂将包括个人教育干预，其中结合了现有的社区资源，可帮助居民做出更健康的生活方式选择。如果强化干预方法具有成本效益，则该模式可以传播到美国数千个拥有 DEP 的社区。许多慢性疾病受到活动和饮食的影响。我们的生活方式干预如果成功，应该转化为 2 型糖尿病以外领域的公共健康益处，例如肥胖、高血压、心血管健康和癌症预防，从而大大增加社会的潜在益处，并成为基于社区的模式健康促进计划。