Selective Ablation of Dental Caries and Composites

龋齿和复合材料的选择性消融

• 批准号: 7924809
• 负责人: Daniel Fried
• 金额: $ 35.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924809
• 关键词: Ablation; Adhesions; Adhesives; Appearance; Area; Bicuspid; Carbon Dioxide; Chemicals; Clinical; Clinical Research; Computers; Coupled; Dental; Dental Amalgam; Dental Care; Dental Cavity Preparation; Dental Enamel; Dental caries; Dentin; Dentinoenamel junction; Dentistry; Dentition; Deposition; Development; Diagnostic; Discrimination; Electronics; Ensure; Excision; Feedback; Floor; Fluorescence; Fracture; Frequencies; Future; Goals; Hand; Heating; Human; Image; Imaging Device; In Situ; Individual; Inflammation; Knowledge; Lasers; Lead; Lesion; Measurement; Measures; Mechanics; Medical Imaging; Medicine; Methods; Microradiography; Microscope; Minerals; Monitor; Morphology; Noise; Operative Surgical Procedures; Optical Coherence Tomography; Optical Methods; Optics; Peripheral; Physiologic pulse; Pilot Projects; Polarization Microscopy; Positioning Attribute; Property; Pulp Chambers; Research; Residual state; Resistance; Resolution; Scanning; Schedule; Site; Staging; Stress; Surface; Surgical incisions; System; Technology; Temperature; Testing; Thick; Time; Tissues; Tooth structure; Water; absorption; arm; base; composite restoration; demineralization; design; imaging modality; impression; in vivo; innovation; irradiation; nanosecond; new technology; novel; operation; public health relevance; repaired; restorative material; sound; synchrotron radiation; tool; tooth surface; vibration

DESCRIPTION (provided by applicant): The overall objective of this proposed research is to increase our fundamental understanding of the interaction of high intensity laser radiation with dental hard tissues and apply that knowledge to the development of laser- based methods that selectively remove dental caries and composite restorative materials using an integrated approach of computer-controlled laser beam scanning coupled with optical methods of feedback. In addition to eliminating the noise and vibration associated with the dental hand-piece, lasers offer several unique advantages over current surgical technology for conservative dentistry. Under the appropriate irradiation conditions, lasers are capable of achieving markedly higher precision and selectivity, are well-suited for electronic control, can induce beneficial chemical and morphological changes in the walls of the drilled cavity that can render the tissues more resistant to further dental decay with enhanced adhesive properties to restorative materials. The specific aims of this proposal are to test the following hypotheses: 1) natural and artificial caries lesions can be selectively removed from tooth surfaces with minimal peripheral damage to sound tissues using image-guided laser ablation, 2) optical coherence tomographic imaging can be successfully used as an in situ diagnostic for laser ablation, 3) dental composite based materials can be selectively removed from tooth surfaces without excessive heat accumulation or mechanical damage to the surrounding sound enamel and dentin. These fundamental studies will significantly advance our overall knowledge of laser-tissue interactions and facilitate the development of safer and more efficient laser systems for the removal of dental caries and restorative materials. The use of highly selective laser systems for the removal of dental caries and dental composites is likely to lead to the practice of more conservative dental procedures that will reduce the amount of healthy tissue loss that is generally associated with conventional cavity preparations and the repair of existing composite restorations. PUBLIC HEALTH RELEVANCE: These fundamental studies will significantly advance our overall knowledge of laser-tissue interactions and facilitate the development of safer and more efficient laser systems for the removal of dental caries and restorative materials. Use of those laser systems is likely to lead to the practice of more conservative dental procedures that will markedly reduce the amount of healthy tissue loss that is generally associated with conventional cavity preparations.

描述（由申请人提供）：这项拟议研究的总体目标是增加我们对高强度激光辐射与牙齿硬组织相互作用的基本了解，并将这些知识应用于基于激光的方法的发展，这些方法有选择地去除牙齿龋齿和牙齿龋齿和复合修复材料采用计算机控制的激光束扫描的集成方法，以及光学方法的反馈方法。除了消除与牙科手式相关的噪声和振动外，激光比当前的保守牙科手术技术具有多个独特的优势。在适当的辐照条件下，激光器能够明显提高精度和选择性，非常适合电子控制，可以在钻孔腔的壁上诱导有益的化学和形态变化具有增强的粘合性能对修复材料。该提案的具体目的是检验以下假设：1）可以从图像引导的激光消融中选择性地从牙齿表面中选择性地从牙齿表面中选择性地从牙齿表面中删除自然和人造性病变，2）光学相干性层析成像可以成功地进行3）可以选择性地从牙齿表面上除去，而不会过多热量积聚或机械损坏周围的声音搪瓷和牙本质，则可以选择性地从牙齿表面中切除牙科材料。这些基本研究将大大提高我们对激光 - 组织相互作用的整体知识，并促进更安全，更有效的激光系统的开发，以去除龋齿和修复材料。使用高度选择性激光系统去除龋齿和牙科复合材料可能会导致实践更保守的牙科手术，从而减少通常与常规腔体制剂相关的健康组织损失量和现有的修复复合修复体。 公共卫生相关性：这些基本研究将大大提高我们对激光 - 组织相互作用的整体知识，并促进开发更安全，更有效的激光系统，以去除龋齿和恢复性材料。这些激光系统的使用可能会导致更保守的牙科手术实践，这将显着减少与常规腔体制剂有关的健康组织损失的量。