Optical Methods for Lesion Activity Assessment

病变活动评估的光学方法

基本信息

批准号：
9769674
负责人：
Daniel Fried
金额：
$ 38.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9769674
关键词：
Air Chemicals Clinical Management Clinical Markers Clinical Research Clinical assessments Custom Dehydration Dental Cavity Preparation Dental caries Development Diagnosis Dimensions Effectiveness Fissural Fluorides Hand Image Imaging technology In Vitro Intervention Lesion Measurable Measurement Measures Methods Microradiography Minerals Mission Monitor National Institute of Dental and Craniofacial Research Nonionizing Radiation Optical Methods Optics Plant Roots Polarization Microscopy Population Porosity Public Health Research Root Caries Severities Stains Structure Surface Testing Therapeutic Intervention Thick Time Tissues Tooth structure clinical decision-making contrast imaging deciduous tooth demineralization design imaging modality improved in vivo light scattering novel diagnostics preservation remineralization restoration success tool

项目摘要

ABSTRACT The overall objective of this proposed research is to develop methods for the clinical assessment of lesion structure and activity. New imaging technologies employing non- ionizing radiation are needed to aid in caries diagnosis and management. It is not sufficient to simply detect caries lesions, methods are needed to assess the lesion activity and determine if chemical intervention is needed. Measurements of lesion structure and the optical and dimensional changes to lesions that occur during dehydration offer the potential for lesion activity assessment during a single examination. The central hypothesis underlying this proposal is that there are structural differences between active and arrested lesions and these differences can be quantified using near- IR (NIR) imaging methods. The objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that NIR reflectance measurements during lesion dehydration are more sensitive to changes in lesion structure and activity than existing methods and that NIR imaging can be used to assess the activity of coronal caries lesions in vivo. (2) To test the hypothesis that cross-polarization OCT (CP-OCT) can be used to assess changes in lesion structure and activity in the pits and fissures of primary teeth before and after chemical intervention. (3) To test the hypothesis that CP-OCT can be used to assess the activity of lesions on root surfaces and monitor the efficacy of conservative intervention in vivo. Success of this proposal will provide methods for assessing the activity of lesions in a single examination and for monitoring the efficacy of chemical intervention, thereby enabling the use of new intervention therapies to avert cavitation and restoration.

抽象的这项拟议研究的总体目的是开发临床的方法病变结构和活动的评估。采用非 - 需要电离辐射以帮助龋齿诊断和管理。它不是足以简单地检测到龋齿病变，需要方法来评估病变活动并确定是否需要化学干预。病变的测量结构以及对病变的光学和尺寸变化脱水为一次检查期间的病变活性评估提供了潜力。该提议的基础假设是存在结构差异在活跃的和被捕的病变之间，可以使用近接近 IR（NIR）成像方法。该提议的目标将通过以下特定目的：（1）检验NIR反射测量的假设病变期间脱水对病变结构和活性的变化更敏感比现有方法，NIR成像可用于评估体内冠状动脉病变。（2）检验交叉极化OCT的假设（CP-OCT）可用于评估坑中病变结构和活动的变化，化学干预之前和之后的原发牙的裂缝。（3）测试 CP-OCT可用于评估病变在根表面的活性的假设并监测体内保守干预的功效。该提案的成功将提供评估病变活性的方法单次检查和监测化学干预的功效，从而可以使用新的干预疗法来避免空化和恢复。