Development of clinically translatable MRI methodologies for the thoracic spinal cord

胸脊髓临床可转化 MRI 方法的开发

• 批准号: 10728689
• 负责人: Kristin Poole O'Grady
• 金额: $ 17.5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728689
• 关键词: Abscess; Acute Disseminated Encephalomyelitis; Address; Air; Anatomy; Anisotropy; Applications Grants; Astrocytoma; Attention; Brain; Breathing; CD2 gene; Cardiac; Cervical; Cervical spinal cord structure; Chemicals; Chest; Chest imaging; Claustrophobias; Clinical; Clinical Management; Clinical Protocols; Collaborations; Communities; Computer software; Data; Development; Diagnosis; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease model; Dural Arteriovenous Fistulas; Early treatment; Echo-Planar Imaging; Ependymoma; Evaluation; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Heart; Human Pathology; Image; Inflammatory; Ischemia; Liquid substance; Literature; Lumbar Regions; Lumbar spinal cord structure; Lung; Magnetic Resonance Imaging; Magnetism; Methodology; Methods; Monitor; Morphologic artifacts; Motion; Multiple Sclerosis; Noise; Pain; Pathology; Patient Care; Patient-Focused Outcomes; Patients; Physiological; Predisposition; Protocols documentation; Recovery; Reproducibility; Research; Resolution; Respiration; Respiratory Diaphragm; Rest; Scanning; Secondary to; Signal Transduction; Speed; Spinal Cord; Structure; T2 weighted imaging; Techniques; Testing; Thoracic spinal cord structure; Time; Tissues; Translational Research; Translations; Trauma; Work; anatomic imaging; bone; clinical care; clinical development; clinical practice; clinical translation; clinically relevant; cohort; gray matter; healthy volunteer; hemangioblastoma; high resolution imaging; image translation; imaging modality; imaging scientist; improved; indexing; innovation; method development; multiple sclerosis patient; neuroimaging; patient population; rapid diagnosis; research study; respiratory; spinal cord imaging; spine bone structure; tool; translational scientist; treatment planning; tumor; white matter

PROJECT SUMMARY Magnetic resonance imaging (MRI) is critical to diagnosing pathology of the human spinal cord for a wide array of diseases, conditions, and trauma. The thoracic region of the spinal cord, corresponding to vertebral levels T1-T12, is frequently involved in conditions such as cord ischemia, dural arteriovenous fistulas, and hemangioblastoma as well as inflammatory diseases such as multiple sclerosis (MS). There is a clear need for high quality, nondegraded MRI of the thoracic cord to support diagnosis and treatment planning in the clinical setting as well as to provide comprehensive evaluation of the spinal cord in translational research studies. Unfortunately, MRI methods development for this anatomy significantly lags that for the brain and cervical spinal cord. The thoracic spinal cord is especially challenging to image because, in addition to small size, physiological motion, and low intra-cord tissue contrast between gray and white matter, this region is directly adjacent to the lungs and diaphragm and suffers the most from respiration artifacts relative to the cervical and lumbar regions. Respiration artifacts are caused by the physical motion of the lungs and diaphragm as well as the temporally varying B0 field homogeneity. Conventional, clinical MRI techniques for the thoracic spinal cord are often degraded by these artifacts which can necessitate re-acquisition (lengthening scan duration) or canceling studies, which can negatively impact clinical management. The overarching goal of this project is to systematically optimize anatomical and diffusion MRI sequences for the thoracic spinal cord that employ clinically translatable techniques to mitigate these technical hurdles with specific attention to motion and respiration artifacts. This goal will be addressed in two aims: Aim 1) Optimize clinically relevant anatomical MRI sequences for the thoracic spinal cord at 3T and Aim 2) Optimize diffusion MRI sequences for the thoracic spinal cord at 3T. Completion of these aims will provide a clinically feasible protocol for improved anatomical and diffusion MRI that addresses an important gap in current spinal cord MRI coverage. Furthermore, this study will generate preliminary data and set the stage for future translational research studies that will implement comprehensive spinal cord imaging to improve our understanding of spinal cord pathologies in patient populations.

项目摘要 磁共振成像（MRI）对于诊断人脊髓的病理至关重要 一系列疾病，状况和创伤。脊髓的胸部区域，对应于椎骨 T1-T12的水平经常参与诸如脐带缺血，硬脑膜动静脉瘘和等疾病 血管母细胞瘤以及多发性硬化症（MS）等炎症性疾病。显然需要 高质量的胸部绳索的非核MRI支持临床的诊断和治疗计划 在翻译研究中，设置以及对脊髓的全面评估。 不幸的是，这种解剖结构的MRI方法显着落后于大脑和宫颈 脊髓。胸脊髓对图像特别具有挑战性，因为除了小尺寸外， 生理运动以及灰质和白质之间的低谱管内组织对比，该区域直接 与肺部和隔膜相邻，并且相对于宫颈和 腰部地区。呼吸伪像是由肺和隔膜的身体运动引起的 时间上变化的B0场均匀性。胸脊髓的常规临床MRI技术 这些文物通常会降级，这些文物需要重新攻击（延长扫描持续时间）或 取消研究，可能对临床管理产生负面影响。这个项目的总体目标是 系统地优化采用胸脊髓的解剖和扩散MRI序列 临床上可翻译的技术，以减轻这些技术障碍，以特别关注运动和 呼吸伪像。该目标将在两个目标中解决：目标1）优化临床相关的解剖学 在3T处的胸脊髓的MRI序列和目标2）优化扩散MRI序列 胸脊髓3T。这些目标的完成将提供临床上可行的协议，以改善 解剖学和扩散MRI解决了当前脊髓MRI覆盖范围的重要差距。 此外，这项研究将产生初步数据，并为将来的翻译研究奠定了基础 这将实施全面的脊髓成像，以提高我们对脊髓病理的理解 在患者人群中。