Development of Advanced MRI for the Thoracolumbar Spinal Cord for Clinical Application

开发用于临床应用的胸腰段脊髓先进 MRI

基本信息

批准号：
10213028
负责人：
Kristin Poole O'Grady
金额：
$ 15.56万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-08 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213028
关键词：
Academic Medical Centers Accidents Address Advanced Development Affect Age Anatomy Anisotropy Area Atrophic Autonomic Pathways Axon Back Pain Biological Bladder Bladder Dysfunction Brain Caring Central Nervous System Diseases Cervical spinal cord structure Chest Chronic Clinical Clinical Management Demyelinations Development Diagnosis Diffuse Diffusion Diffusion Magnetic Resonance Imaging Disease Disease Progression Disease susceptibility Enrollment Environment Female Functional Magnetic Resonance Imaging Functional disorder Gait Goals Grant Height Image Immune Immunologic Factors Immunologics Immunology Impairment Infection Institutes Institution Knowledge Lesion Lower Extremity Magnetic Resonance Imaging Measures Mediating Mentors Mentorship Methods Microscopic Motion Motivation Multiple Sclerosis Multiple Sclerosis Lesions Myelin Nerve Degeneration Neurologic Neurologic Deficit Noise Onset of illness Outcome Pathology Patients Physiologic pulse Physiology Population Prevalence Protocols documentation Quality of life Radiology Specialty Recovery Relapsing-Remitting Multiple Sclerosis Reproducibility Research Resolution Rest Role Science Sex Differences Signal Transduction Speed Spinal Cord Spinal Cord Lesions Spinal cord damage Structure Symptoms Technical Expertise Time Tissues Training Translations Transverse Myelitis Trauma Variant Weight Widespread Disease Woman Work age difference anatomic imaging base bioimaging biological sex burden of illness career development clinical application clinical translation cohort disability disease phenotype early experience experience hand dysfunction healthy volunteer illness length image processing imaging modality imaging scientist improved indexing male men method development multimodality multiple sclerosis patient nervous system disorder neuromuscular potential biomarker programs research and development sex spinal cord imaging white matter

项目摘要

PROJECT SUMMARY In multiple sclerosis (MS), an estimated 40% of spinal cord (SC) lesions are located in the thoracic and lumbar segments of the SC. These regions of the SC are associated with lower limb and bladder function, the most prevalent targets for neurological deficits in MS, but the thoracolumbar SC is significantly understudied and lesions here are rarely identified with clinical magnetic resonance imaging (MRI) protocols. Conventional clinical MRI for the thoracolumbar SC lacks sensitivity to lesions and microscopic pathology that may drive impairment, and is unable to discern the extent of demyelination or possible altered function of the lower cord. The overarching goal of this project is to develop and optimize MRI methods for quantitative characterization of tissue structure and function in the thoracolumbar SC in patients with MS. I will complete this goal in three aims: Aim 1) Develop and optimize anatomical, diffusion, and resting-state functional MRI methods for the thoracolumbar SC at clinical field strength (3T), Aim 2) Quantify the reproducibility of the thoracolumbar MRI protocol in healthy volunteers and characterize biological variation (e.g. age and sex differences) in thoracolumbar cord structure and function, and Aim 3) Apply the multimodal MRI toolset to study relationships between MRI indices, biological variables (age, sex), and clinical measures of lower limb and bladder dysfunction in MS patients. Completion of these aims and the mentored training in clinical and immunological features of MS outlined in this proposal will provide me with technical training in advanced MRI pulse programming and methods development for the spinal cord, and expanded didactic training in immunology, sex differences in MS, neuromuscular physiology, and clinical management of MS. In addition to the technical expertise above, this grant will allow me to transition to independence as a translational imaging scientist. My institution has guaranteed at least 90% protected time to the proposed research and career development activities. My professional development will be guided by an interdisciplinary mentorship committee led by my primary mentor Dr. Seth Smith and co-mentors Dr. John Gore and Dr. Subramaniam Sriram. Dr. Smith is an expert in pulse programming and deployment of advanced MRI methods in clinical populations, and Drs. Gore and Siram are renowned for their work in biomedical imaging methods and applications and immunological factors in MS lesion recovery, respectively. I am capitalizing on Vanderbilt’s strengths in translational imaging research and readily available clinical subjects by working with mentors and collaborators in the Institute of Imaging Science and in clinical departments of the Vanderbilt University Medical Center. This makes Vanderbilt a unique and stimulating environment for professional development and completion of my proposed studies.

项目概要在多发性硬化症 (MS) 中，估计 40% 的脊髓 (SC) 病变位于胸部和胸部 SC 的腰段。 SC 的这些区域与下肢和膀胱功能相关。多发性硬化症神经功能缺损最常见的目标，但胸腰椎 SC 的研究明显不足传统的磁共振成像 (MRI) 方案很少能识别出此处的病变。胸腰段 SC 的临床 MRI 对病变和微观病理缺乏敏感性，这可能会导致损伤，并且无法辨别脱髓鞘的程度或下脊髓的可能功能。该项目的总体目标是开发和优化用于定量表征的 MRI 方法我将在三年内完成这个目标。目标：目标 1) 开发和优化解剖、扩散和静息态功能 MRI 方法，用于临床场强 (3T) 下的胸腰椎 SC，目标 2) 量化胸腰椎 MRI 的可重复性健康志愿者的协议和表征生物变异（例如年龄和性别差异）胸腰椎结构和功能，目标 3) 应用多模态 MRI 工具集研究关系 MRI 指数、生物变量（年龄、性别）以及下肢和膀胱的临床测量之间的关系完成这些目标以及临床和免疫学方面的指导培训。本提案中概述的 MS 功能将为我提供高级 MRI 脉冲的技术培训脊髓的编程和方法开发，以及免疫学方面的扩展教学培训， MS 的性别差异、神经肌肉生理学和 MS 的临床管理。除了上述技术专长之外，这笔赠款将使我能够过渡为独立人士我的机构保证了至少 90% 的受保护时间。我的研究和职业发展活动将受到跨学科的指导。导师委员会由我的主要导师 Seth Smith 博士和共同导师 John Gore 博士和 Dr. John Gore 博士领导。 Subramaniam Sriram 博士是脉冲编程和先进 MRI 方法部署方面的专家。戈尔和西拉姆博士因其在生物医学成像方法方面的工作而闻名。我分别利用了多发性硬化症病变恢复中的应用和免疫因素。范德比尔特大学在转化成像研究和现成临床受试者方面的优势影像科学研究所和范德堡大学临床部门的导师和合作者大学医疗中心使范德比尔特成为一个独特且令人兴奋的专业环境。发展和完成我提议的研究。