Imaging Dental Caries with SWIR Light

使用短波红外光对龋齿进行成像

基本信息

批准号：
10616510
负责人：
Daniel Fried
金额：
$ 38.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10616510
关键词：
Bicuspid Clinical Clinical Research Clinical Trials Dehydration Dental Dental Enamel Dental caries Dentin Detection Development Diagnosis Diagnostic Early Diagnosis Future Image Imaging technology In Vitro Intervention Ionizing radiation Knowledge Lateral Lesion Light Measurement Mission Modeling Monitor National Institute of Dental and Craniofacial Research Nonionizing Radiation Penetration Performance Public Health Research Schedule Shortwave Infrared Imaging Silicon Stains Structure Superficial Lesion Surface Testing Time Tissues Tooth structure Transillumination Translating Water absorption demineralization detection method diagnostic tool imaging approach imaging modality improved light scattering multimodality novel diagnostics novel imaging technology optical imaging overtreatment preservation radiological imaging remineralization restoration restorative composite restorative material screening sensor sound success tooth surface

项目摘要

ABSTRACT The overall objective of this proposed research is to develop improved methods for the detection and diagnosis of dental caries (dental decay). New, more sophisticated diagnostic tools are needed for the detection and characterization of caries lesions in the early stages of development. If carious lesions are detected early enough, before cavitation, then they can be arrested/remineralized by non-surgical means. Clinicians need new imaging technologies employing non-ionizing radiation to aid in caries diagnosis and management, to reliably track the course of lesions over an extended time period in order to determine whether the lesion is active and expanding or whether it has been arrested, and determine if intervention is needed. Short wavelength infrared light (SWIR) is defined as light from 1000-2500-nm beyond the reach of conventional silicon based sensors. Longer wavelengths offer significant advantages for imaging caries lesions including higher contrast between sound and demineralized tissues due to reduced light scattering and higher water absorption and reduced interference from stains that do not absorb light at wavelengths greater than 1200-nm. We hypothesize that the wavelength region from 1300 to 2300-nm offers the greatest potential for new optical imaging modalities. The overall objectives of this proposal will be achieved through the following specific aims. (1) To test the hypothesis that imaging with light in the previously unexplored wavelength range from 1700-2350-nm in the SWIR will yield increased contrast between sound tissues and demineralized tissues on tooth coronal and root surfaces. (2) To test the hypothesis that multispectral and multimodal SWIR imaging approaches can be used to significantly improve the diagnosis of caries lesions. (3) To test the hypothesis that imaging at longer wavelengths in the SWIR can be used to improve the diagnosis of lesions on tooth proximal surfaces by assessing cavitation and deeply penetrating lesions. It is likely that if these studies and future clinical trials are a success, that this novel technology for imaging dental hard tissue will be employed for the detection, diagnosis and monitoring of early carious lesions without the use of ionizing radiation, thereby enabling conservative non-surgical intervention and the preservation of healthy tissue structure.

抽象的这项研究的总体目标是开发改进的方法龋齿（蛀牙）的检测和诊断。新的、更复杂的需要诊断工具来检测和表征龋齿病变发展的早期阶段。如果足够早地发现龋齿病变，空化，然后可以通过非手术手段阻止/再矿化它们。临床医生需要采用非电离辐射的新成像技术来帮助治疗龋齿诊断和管理，在较长时间内可靠地跟踪病变进程以确定病变是否活跃并扩大或是否已发生被逮捕，并确定是否需要干预。短波长红外光 (SWIR) 被定义为传统硅无法达到的 1000-2500 nm 范围内的光基于传感器。较长的波长为龋齿成像提供了显着的优势病变包括健全组织和脱矿组织之间较高的对比度，这是由于减少光散射和提高吸水率，并减少干扰不吸收波长大于 1200 nm 的光的染色剂。我们假设 1300 至 2300 nm 的波长区域为新产品提供了最大的潜力光学成像方式。本提案的总体目标将实现通过以下具体目标。 (1) 检验光成像的假设 SWIR 中先前未探索的 1700-2350 nm 波长范围将产生牙冠上健全组织和脱矿组织之间的对比度增加和根面。 (2) 检验多光谱和多模态 SWIR 的假设成像方法可用于显着改善龋齿病变的诊断。 (3) 检验可以使用短波红外中较长波长成像的假设通过评估空化来改善牙齿近端表面病变的诊断以及深部穿透性病变。如果这些研究和未来的临床试验很可能是成功的，这种用于牙齿硬组织成像的新技术将被采用用于检测、诊断和监测早期龋损，无需使用电离辐射，从而实现保守的非手术干预和保存健康的组织结构。