T and B Cell Collaboration in Germinal Centers and Beyond

T 细胞和 B 细胞在生发中心及其他区域的合作

• 批准号: 10753621
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.55万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753621
• 关键词: 2019-nCoV; Address; Antibodies; Area; Autoimmune Diseases; B-Lymphocytes; British Columbia; COVID-19 pandemic; COVID-19 vaccine; Canada; Cell Communication; Cells; Collaborations; Communicable Diseases; Creativeness; Data; Development; Disease; Educational workshop; Fostering; Future; Health; Human; Immune response; Immune system; Immunity; Immunologic Memory; Immunologics; Infection; Joints; Knowledge; Learning; Malignant Neoplasms; Mentors; Methodology; Modeling; Outcome; Persons; RNA vaccination; Research; Research Personnel; Research Priority; Science; Scientist; Structure of germinal center of lymph node; T-Lymphocyte; Technology; Therapeutic; Vaccines; Variant; Viral; clinical practice; combat; design; improved; interest; multidisciplinary; posters; prospective; response; symposium; tertiary lymphoid organ

ABSTRACT Support is requested for a Keystone Symposia conference entitled T and B Cell Collaboration in Germinal Centers and Beyond, organized by Drs. Shane Crotty, Michela Locci and Jennifer Gommerman. The conference will be held in Whistler, British Columbia, Canada from October 1-4, 2023. T cell/B cell interactions are fundamental for numerous immune responses. And, as the COVID-19 pandemic demonstrated, the successful development of COVID-19 vaccines highlighted the extreme value of T and B cell interactions for protective immunity. For example, the development of antibodies able to neutralize variants as diverse as Omicron, after not one or two but after three other mRNA immunizations, with the same ancestral SARS-CoV-2 Spike, is a dramatic example of the importance of germinal centers in protective immunity, and the brilliance of the immune system in rapidly evolving T-dependent B cell responses capable of neutralizing extreme viral variants the cells never previously encountered in the germinal centers. However, there remains much to be learned about the critical importance of T cell/B cell interactions and germinal centers for vaccines and infectious diseases. Furthermore, the relevance of these immunological interactions is much broader in biomedicine. T cell/B cell interactions are important in many autoimmune diseases. Moreover, this conference will be held jointly with the Keystone Symposium on B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics and there will be joint sessions covering T cell/B cell interactions in cancer.

抽象的 请求支持Keystone研讨会会议，标题为“生发中的T和B细胞协作” 中心及以后，由博士组织。 Shane Crotty，Michela Locci和Jennifer Gommerman。会议 将于2023年10月1日至4日在加拿大不列颠哥伦比亚省的惠斯勒举行。 T细胞/B细胞相互作用对于众多免疫反应至关重要。而且，作为19号大流行 证明，Covid-19疫苗的成功开发突出了T和B细胞的极端值 保护性免疫的相互作用。例如，能够将变体中和的抗体开发为 作为Omicron的多样化，不是一两个，而是在另外三个mRNA免疫后，具有相同的祖先 SARS-COV-2 Spike是生发中心在保护性免疫中的重要性的一个戏剧性例子， 免疫系统在快速发展的T依赖性B细胞反应中的光彩能够中和极端 病毒变体在生发中心从未遇到过细胞。但是，还有很多 了解T细胞/B细胞相互作用和生发中心在疫苗和 传染病。此外，这些免疫相互作用的相关性在很广泛 生物医学。 T细胞/B细胞相互作用在许多自身免疫性疾病中很重要。而且，这次会议 将与B细胞和三级淋巴结构上的Keystone研讨会共同举办：新兴靶标 在癌症治疗剂中，将会举行涵盖癌症中T细胞/B细胞相互作用的联合课程。