Myeloid Cell Diversity: From Fundamental Biology to Disease States

骨髓细胞多样性：从基础生物学到疾病状态

• 批准号: 10753412
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.25万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753412
• 关键词: Academia; Achievement; Adopted; Aging; Biology; Canada; Cardiovascular Diseases; Cells; Cellular biology; Collaborations; Cues; Dendritic Cells; Development; Disease; Educational workshop; Environment; Fostering; Future; Health; Heterogeneity; Image; Imaging technology; Immunity; Industry; Inflammation; Inflammatory; Innate Immune System; Knowledge; Learning; Life Style; Macrophage; Malignant Neoplasms; Mentors; Metabolic; Metabolic Diseases; Methodology; Myelogenous; Myeloid Cells; Nerve Degeneration; Outcome; Quail; Regulation; Research; Research Personnel; Resources; Science; Scientist; Shapes; Technology; Time; Tissues; Training; adaptive immune response; clinical practice; combat; design; first responder; frontier; immune function; improved; innate immune function; lens; meetings; monocyte; multidisciplinary; neutrophil; posters; programs; prospective; single cell technology; symposium; tool

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Mechanisms, Diversity and Function, organized by Drs. Andrés Hidalgo, Daniela Quail and Lai Guan Ng. The conference will be held in Banff, Canada from January 28-31, 2024. Myeloid cells are major components of the innate immune system that are first responders to inflammatory cues and critical to engage long-lasting adaptive immune responses. Understanding the fundamental biology governing myeloid development and function in steady-state and inflammatory contexts is imperative to developing treatments to combat cancer, cardiovascular disease, neurodegeneration and other diseases. With the rising use of single cell technologies, the vast extent of myeloid diversity and heterogeneity is being unveiled for the first time, creating new knowledge gaps surrounding myeloid functional states in health and disease. This Keystone Symposia conference will explore transformative research concepts that challenge current views of myeloid biology. The conference program was designed to leverage cutting-edge imaging technologies to learn about myeloid innate immune functions across tissue environments. It will also promote discussions that will reevaluate the fundamental biology underlying myeloid development in steady-state and inflammation, as well as challenge current concepts of how we define myeloid cell subsets versus functional states. The program will also include sessions that will consider the impact of trained immunity or lifestyle on myeloid states in health and disease and discuss emerging concepts in metabolic regulation of myeloid cells in disease and aging. Attendees will learn about new tools and resources that are available to study the diversity of myeloid states in various experimental contexts and will be challenged to rethink existing dogma that underestimates the breadth of myeloid cell contributions to health and disease.

抽象的 请求支持Keystone研讨会会议，标题为“髓样细胞：机制，多样性和多样性” 功能，由Drs组织。 AndrésHidalgo，Daniela Quail和Lai Guan Ng。会议将在 加拿大班夫，2024年1月28日至31日。 髓样细胞是先天免疫系统的主要组成部分，是对炎症的第一反应者 提示和至关重要的是持续持久的适应性免疫回报。了解基本生物学 必须在稳态和炎症环境中髓样发展和功能 开发治疗方法，以打击癌症，心血管疾病，神经退行性疾病和其他疾病。和 单细胞技术的使用不断上升，髓样多样性和异质性的广泛程度正在 第一次揭幕，在健康和 疾病。这次Keystone研讨会会议将探索挑战的变革性研究概念 髓样生物学的当前观点。会议计划旨在利用尖端成像 了解跨组织环境的髓样固有免疫功能的技术。它也会促进 讨论将重新评估稳态发展的基本生物学的基本生物学 炎症，以及挑战当前我们如何定义髓样细胞子集与功能的概念 国家。该计划还将包括会议，以考虑训练有素的免疫或生活方式的影响 健康和疾病的髓样状态以及讨论髓样细胞代谢调节中的新兴概念 疾病和衰老。与会者将了解可用于研究多样性的新工具和资源 在各种实验环境中的髓样状态，将面临重新考虑现有教条的挑战 低估了髓样细胞对健康和疾病的贡献。