Immunity and Aging

免疫与衰老

• 批准号: 10753410
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.92万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10753410
• 关键词: Adaptive Immune System; Address; Aging; Area; Artificial Intelligence; Basic Science; Big Data; Biological; Biology of Aging; Biotechnology; COVID-19 pandemic; Canada; Chronic Disease; Collaborations; Communicable Diseases; Communities; Development; Disease; Distant; Drug Industry; Educational workshop; Elderly; Emerging Technologies; Fertilization; Functional disorder; Goals; Health; Homeostasis; Human; Human Biology; Immune; Immune Targeting; Immune response; Immune system; Immunity; Immunology; Inflammaging; Inflammation; Innate Immune System; International; Interruption; Knowledge; Learning; Longevity; Mentors; Metabolism; Methodology; Neurobiology; Normal tissue morphology; Outcome; Pathology; Predisposition; Process; Research; Research Personnel; Risk Factors; Science; Scientist; Speed; Tissues; Touch sensation; Translations; Vaccines; age effect; age related; body system; clinical practice; combat; design; frontier; functional decline; healthspan; hematopoietic stem cell aging; immune activation; immune function; improved; insight; interest; mortality; multidisciplinary; novel therapeutics; posters; programs; prospective; single cell sequencing; stem cell biology; stem cells; symposium; therapy development

ABSTRACT Support is requested for a Keystone Symposia conference entitled Immunity and Aging, organized by Drs. Danica Chen, Sun Hur and Joan Mannick. The conference will be held in Whistler, Canada from October 1-4, 2023. Aging is the single largest risk factor for a wide spectrum of chronic diseases and mortality. An outstanding question in human biology is how we lose the ability to maintain homeostasis and become susceptible to diseases and mortality. However, as groundbreaking research has emerged over the past decade, there is evidence that the decline in function of aging organ systems is caused by a discreet number of biological mechanisms. For instance, recent single cell sequencing studies suggest that one mechanism contributing to dysfunction of the aging immune system is a widespread basal activation of immune cells across tissues. Additionally, dysfunction of the aging immune system results in suboptimal immune responses to vaccines and infectious diseases in older adults, as has been highlighted recently by the COVID-19 pandemic. This Keystone Symposia conference will provide an international venue for researchers to discuss these timely topics, specifically, to understand how the immune system becomes dysregulated during the aging process and how the aging immune system impinges upon the tissue functions, organismal health span and survival. This program touches on questions including: (i) how aging of hematopoietic stem cells contribute to dysfunction of the aging immune system and impacts distant tissues and (ii) how age-related changes in innate and adaptive immune function compromise immunity. Other sessions will discuss the origins of aging-associated inflammation and how inflammation impacts tissue functions and contributes to aging-related conditions. The conference will bring together investigators from multiple fields—immunology, aging, metabolism, stem cell biology and neurobiology—to advance the frontier of immunity and aging.

抽象的 请求支持由Drs组织的Keystone研讨会会议，名为“免疫和衰老”。 Danica Chen，Sun Hur和Joan Mannick。该会议将于10月1-4日在加拿大惠斯勒举行 2023。 衰老是多种慢性疾病和死亡率的最大风险因素。杰出 人类生物学中的问题是我们如何失去维持体内稳态的能力并容易受到影响 疾病和死亡率。但是，随着过去十年中的开创性研究的出现， 衰老器官系统功能下降的证据是由谨慎的生物学数量引起的 机制。例如，最近的单细胞测序研究表明，一种机制有助于 衰老免疫系统的功能障碍是跨组织的免疫细胞的广泛基本激活。 另外，衰老免疫系统功能障碍会导致对疫苗和 老年人的传染病，正如Covid-19的大流行最近所强调的那样。这个基石 研讨会会议将为研究人员提供一个国际场所，以讨论这些及时的主题， 具体而言，了解免疫系统在老化过程中如何失调以及如何 衰老的免疫系统影响组织功能，有机健康跨度和生存。这个程序 涉及问题，包括：（i）造血干细胞的衰老如何导致衰老功能障碍 免疫系统并影响遥远的时机以及（ii）与年龄相关的先天和适应性免疫的变化 功能损害免疫力。其他会议将讨论与衰老相关感染的起源和 炎症如何影响组织功能并有助于与衰老相关的疾病。会议将带来 来自多个领域的研究者 - 免疫学，衰老，代谢，干细胞生物学和 神经生物学 - 促进免疫和衰老的前沿。