Developmental Center to Study Mechanisms & Effects of Chiropractic Manipulation

机制研究发展中心

• 批准号: 7854578
• 负责人: JOEL G PICKAR
• 金额: $ 6.06万
• 依托单位: PALMER COLLEGE OF CHIROPRACTIC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7854578
• 关键词: Animal Model; Biomechanics; Characteristics; Chiropractic manipulation; Classification; Development; Dose; Goals; Intervention; Investigation; Mechanics; Muscle Spindles; Musculoskeletal; Nature; Nervous system structure; Patients; Procedures; Property; Shapes; Signal Transduction; Spinal; Spinal Manipulation; Strategic Planning; Techniques; Tissues; Vertebral column; base; improved; innovation; relating to nervous system; response

DESCRIPTION (provided by applicant): Spinal manipulation is a form of body-based therapy patients often seek for treatment of musculoskeletal complaints. While numerous techniques are used clinically, each shares the common denominator of applying force to the spine. The most form of spinal manipulation includes a short lever, High Velocity, Low Amplitude (HVLA) thrust. Investigation of HVLA spinal manipulation is the focus of this application. By its very nature spinal manipulation is a mechanical intervention that lasts a fraction of a second (typically <200ms) yet produces effects that outlast the intervention itself. How? This question provides the basis for our study and motivates our long term goal: to understand and improve the effective use of spinal manipulation. We will take advantage of an animal model and approaches developed by the two co-leaders in order to understand the relationship between spatial and temporal characteristics of a spinal manipulation and their effects on neural and biomechanical responses from paraspinal tissues. We will determine whether either the responsiveness of primary afferent signaling from paraspinal muscle spindle and/or the passive biomechanical properties of the manipulated region outlast the manipulation itself. Specifically, we will determine if muscle spindle responsiveness increases and spinal stiffness decreases as a function of 1) the spinal manipulation's duration; 2) the presence, magnitude or shape of a preload preceding the manipulation; 3) the anatomical contact point used for the spinal manipulation; and 4) the direction with which the manipulation is applied. The information from these complementary studies will help provide information useful for identifying dosing features of the manipulation to which the nervous system and biomechanical properties of paraspinal tissues may be most responsive and in determining strategies for optimizing the delivery of SM. The study is innovative in that it is represents the first systematic study to investigate this relationship and uses the most commonly applied form of spinal manipulation, a high velocity low amplitude spinal manipulation. The study is significant because it contributes to accomplishing NCCAM's strategic plan by characterizing the biomechanics of manipulative procedures in an effort to clarify the mechanisms of action operative in manipulation practices.

描述（由申请人提供）：脊柱操纵是一种基于身体治疗的患者的一种形式，经常寻求治疗肌肉骨骼疾病。虽然临床上使用了许多技术，但每种技术都具有将力施加到脊柱的共同点。最多的脊柱操作包括短杠杆，高速度，低振幅（HVLA）推力。对HVLA脊柱操作的研究是该应用的重点。从本质上讲，脊柱操纵是一种机械干预措施，持续一秒钟（通常<200ms），但产生的效果超过了干预本身。如何？这个问题为我们的研究提供了基础，并激发了我们的长期目标：了解和改善脊柱操纵的有效使用。我们将利用两个共同领导者开发的动物模型，以了解脊柱操纵的空间和时间特征之间的关系及其对脊柱旁组织的神经和生物力学反应的影响。我们将确定来自脊柱脊髓纺锤体和/或操纵区域的被动生物力学特性的主要传入信号的响应能力是否超过了操纵本身。具体而言，我们将确定肌肉纺锤体反应能力是否增加，脊柱刚度随着1）脊柱操纵持续时间而降低； 2）在操纵前的预紧力的存在，大小或形状； 3）用于脊柱操作的解剖接触点； 4）应用操作的方向。来自这些互补研究的信息将有助于提供有关确定操纵的剂量特征有用的信息，而神经系统和脊柱旁组织的生物力学特性可能最有响应性，并确定优化SM递送的策略。这项研究具有创新性，因为它代表了研究这种关系并使用最常用的脊柱操作形式的第一个系统研究，高速度低幅度脊柱操纵。这项研究之所以重要，是因为它通过表征操纵程序的生物力学来有助于完成NCCAM的战略计划，以阐明操纵实践中的动作操作机制。