Neural & Biomech. Responses to Mech. Feat. of Spinal Manipulation/Pickar, Joel

神经

• 批准号: 7280087
• 负责人: JOEL G PICKAR
• 金额: $ 13.37万
• 依托单位: PALMER COLLEGE OF CHIROPRACTIC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280087
• 关键词: Affect; Alberta province; Animal Model; Biology; Biomechanics; Characteristics; Classification; Dose; Exhibits; Family Felidae; Felis catus; Frequencies; Goals; Intervention; Investigation; Manuals; Mechanics; Modeling; Movement; Muscle; Muscle Spindles; Musculoskeletal; Nature; Nervous system structure; Neurons; Numbers; Outcome; Patients; Procedures; Process; Property; Sensory; Shapes; Signal Transduction; Spinal; Spinal Manipulation; Strategic Planning; Techniques; Testing; Thinking; Tissues; Universities; Vertebral column; base; improved; innovation; neuromechanism; performance site; relating to nervous system; response; spine bone structure; symposium

Spinal manipulation is a form of body-based therapy patients often seek for treatment of musculoskeletal complaints. While numerous techniques are used clinically, each shares the common denominator of applying force to the spine. The most form of spinal manipulation includes a short lever, High Velocity, Low Amplitude (HVLA) thrust. Investigation of HVLA spinal manipulation is the focus of this application. By its very nature spinal manipulation is a mechanical intervention that lasts a fraction of a second (typically <200ms) yet produces effects that outlast the intervention itself. How? This question provides the basis for our study and motivates our long term goal: to understand and improve the effective use of spinal manipulation. We will take advantage of an animal model and approaches developed by the two co-leaders in order to understand the relationship between spatial and temporal characteristics of a spinal manipulation and their effects on neural and biomechanical responses from paraspinal tissues. We will determine whether either the responsiveness of primary afferent signaling from paraspinal muscle spindle and/or the passive biomechanical properties of the manipulated region outlast the manipulation itself. Specifically, we will determine if muscle spindle responsiveness increases and spinal stiffness decreases as a function of 1) the spinal manipulation's duration; 2) the presence, magnitude or shape of a preload preceding the manipulation; 3) the anatomical contact point used for the spinal manipulation; and 4) the direction with which the manipulation is applied. The information from these complementary studies will help provide information useful for identifying dosing features of the manipulation to which the nervous system and biomechanical properties of paraspinal tissues may be most responsive and in determining strategies for optimizing the delivery of SM. The study is innovative in that it is represents the first systematic study to investigate this relationship and uses the most commonly applied form of spinal manipulation, a high velocity low amplitude spinal manipulation. The study is significant because it contributes to accomplishing NCCAM's strategic plan by characterizing the biomechanics of manipulative procedures in an effort to clarify the mechanisms of action operative in manipulation practices.

脊柱操纵是一种基于身体治疗的患者的一种形式，经常寻求治疗肌肉骨骼 投诉。虽然临床上使用了许多技术，但每种技术都共享 向脊柱施加力。最多的脊柱操作包括一个短杠杆，高速度，低速度 振幅（HVLA）推力。对HVLA脊柱操作的研究是该应用的重点。通过它的 脊柱操纵性质非常自然是一种机械干预措施，持续一秒钟（通常 <200ms）却产生的效果超过了干预本身。如何？这个问题为 我们的学习并激发我们的长期目标：了解和改善有效使用脊柱 操纵。我们将利用两个共同领导者开发的动物模型和方法 为了了解脊柱操纵的空间和时间特征之间的关系 及其对脊柱组织组织的神经和生物力学反应的影响。我们将确定是否 从脊髓肌主轴和/或被动的主传入信号传导的响应能力和/或 操纵区域的生物力学特性超过了操纵本身。具体来说，我们会的 确定肌肉纺锤体反应是否增加，脊柱刚度随着1）的作用而降低 脊柱操纵的持续时间； 2）预加载前的存在，大小或形状 操纵； 3）用于脊柱操作的解剖接触点； 4）方向 操作的应用。这些互补研究中的信息将有助于提供 信息可用于识别神经系统和 脊柱组织的生物力学特性可能是最有反应的，并且在确定策略时 优化SM的交付。这项研究具有创新性，因为它代表了第一个系统的研究 研究这种关系，并使用最常用的脊柱操纵形式，高速度 低振幅脊柱操作。这项研究很重要，因为它有助于完成NCCAM 战略计划通过表征操纵程序的生物力学，以澄清 操作实践中的作用机制。