UCD Mutant Mouse Regional Resource Center

都柏林大学突变小鼠区域资源中心

• 批准号: 7914687
• 负责人: KC KENT LLOYD
• 金额: $ 39.47万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2011-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914687
• 关键词: UCD; Mutant; Mouse; Regional; Resource

This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically, and in many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mousecolonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

这是第一个竞争性持续申请的重新提交，要求NIH/NCRR支持 UC Davis突变体区域资源中心（UCD-MMRRC）的下一个5年。总体 UCD-MMRRC的目标是作为MMRRC国家计划的组成部分，以接受， 维持并分布突变小鼠菌株以用于生物医学研究。 MMRRC程序 接受转基因，淘汰和所有其他类型的突变鼠标线，无需向捐赠者和之后 SPF还原和冷冻保存，分布遗传上的繁殖库存性质，在许多情况下 案例表型经过验证的小鼠，向调查人员索取非商业，学术的少量费用 仅研究目的。 UCD-MMRRC目前的人口普查为9000个突变菌株 积极育种鼠类果仁糖，冷冻的胚胎或种质和/或胚胎干细胞克隆。 此外，UCD-MMRRC与其他3个区域MMRRC一起在一个协调的网络中服务 从事实验室鼠标生物学的研究和教学的卓越，提供了科学 具有突变鼠标生物学，殖民地管理，常规和传统和专业知识的专业知识的社区 先进的基因分型和表型能力，临床和解剖病理学服务，应变救援， 传染病诊断和医疗保健以及其他领域。为了与此申请保持一致 状态4相互联系的特定目的，专注于继续维护突变小鼠线 资源，将新产品线接收到资源中，研发项目最终将 转移到资源以提高其功能效率和功能，最后提供 宣传和教育和培训小鼠生物学的机会。这些具体目标是促进的 UCD比较医学中心（CCM）紧密联系的教师专业知识，UCD鼠标 生物学计划（UCD-MBP）和医学和兽医学院。这些关系 允许利用MMRRCSupport，从而为MMRRC带来扩大的机会并受益 国家计划以及生物医学和行为科学研究界。