UCD MUTANT MOUSE REGIONAL RESOURCE CENTER

都柏林大学突变小鼠区域资源中心

• 批准号: 8173536
• 负责人: STEPHEN WILLIAM BARTHOLD
• 金额: $ 210.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173536
• 关键词: Anatomy; Area; Behavioral; Biology; Biomedical Research; Breeding; Censuses; Clinical; Communicable Diseases; Communities; Computer Retrieval of Information on Scientific Projects Database; Cryopreservation; Diagnostic; Education and Outreach; Educational process of instructing; Embryo; Faculty; Fees; Freezing; Funding; Genotype; Grant; Healthcare; Institution; Knock-out; Laboratory mice; Link; Maintenance; Medicine; Mission; Mus; Mutant Strains Mice; Pathology; Phenotype; Request for Applications; Research; Research Personnel; Resources; Services; Source; Training and Education; Transgenic Organisms; United States National Institutes of Health; Veterinary Medicine; comparative; cost; embryonic stem cell; improved; medical schools; mutant; programs; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically. In many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mouse colonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRC support, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 描述（由申请人提供）： 这是对第一个竞争性持续申请的重新提交，该申请要求NIH/NCRR支持UC Davis Mutant Mouse Remotial Resourcation Center（UCD-MMRRC）的未来5年。 UCD-MMRRC的总体目标是作为MMRRC国家计划的组成部分，以接受，维护和分发用于生物医学研究的突变小鼠菌株。 MMRRC计划无需向供体接受转基因，基因敲除和所有其他类型的突变小鼠系，在SPF还原和冷冻保存之后，在遗传上分布了育种库存的库存。在许多情况下，表型验证的小鼠只需向调查人员提供非商业，学术研究目的的少量费用。 UCD-MMRRC目前的人口普查为9000个突变菌株，其维持为积极繁殖小鼠菌落，冷冻胚胎或种质和/或胚胎干细胞克隆。此外，UCD-MMRRC与其他3个区域MMRRC在一个协调的网络中发挥作用区域。为了符合这项任务，该应用程序指出了4个相互联系的特定目的，该目标着重于继续维护资源中的突变鼠标线，将新线条接受到资源，研发项目中，最终将转移到资源中，以提高其功能效率和能力，并最终为小鼠生物学的外展和教育提供机会。 UCD比较医学中心（CCM），UCD小鼠生物学计划（UCD-MBP）以及医学和兽医医学学院紧密相关的教师专业知识，并促进了这些具体目标。这些关系允许利用MMRRC支持，从而为MMRRC国家计划以及生物医学和行为科学研究社区提供了扩大的机会，并受益于MMRRC国家计划。