UCD MUTANT MOUSE REGIONAL RESOURCE CENTER

都柏林大学突变小鼠区域资源中心

• 批准号: 8356921
• 负责人: KC KENT LLOYD
• 金额: $ 70万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-13 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356921
• 关键词: Advertising; Archives; Behavioral; Biotechnology; Breeding; California; Collection; Communities; Contracts; Country; Custom; Data; Data Base Management; Development; Disease; Ensure; Equipment and supply inventories; Ethylnitrosourea; Fostering; Funding; Genes; Genetic; Genotype; Grant; Human Resources; Informatics; Injection of therapeutic agent; Institutes; Institution; Intracytoplasmic Sperm Injections; Laboratory Research; Life; Marketing; Missouri; Mouse Strains; Mutant Strains Mice; National Center for Research Resources; North Carolina; Phenotype; Policies; Prevention strategy; Principal Investigator; Procedures; Research; Research Infrastructure; Research Personnel; Resource Development; Resources; Role; Services; Source; System; The Jackson Laboratory; Transgenic Organisms; United States National Institutes of Health; Universities; Work; blastocyst; cost; embryonic stem cell; human disease; innovation; mouse model; mutant; novel diagnostics; prevent; programs; public health relevance; repository; web site

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This proposal seeks to competitively renew funding for infrastructure, personnel, and resources in support of the MMRRC at the University of California (UC) Davis (UCD-MMRRC). The UCD-MMRRC, alongside 2 centers at the University of Missouri-Columbia and University of North Carolina-Chapel Hill, and an Informatics, Coordination, and Service Center (ICSC) at The Jackson Laboratory, serves as the distribution archives and data center for the MMRRC National Program. Since its inception 10 years ago, the UCD- MMRRC has been one of the primary mutant mouse archive and distribution repositories in the world. We are the largest archive of three centers, with an inventory of over 28,500 mutant mouse lines representing ~98% of all live colonies, germplasm, and/or embryonic stem (ES) cells in the system. The UCD-MMRRC has fulfilled nearly 6000 orders from more than 2000 investigators at 500 institutions in 30 countries. We have also been a leader in innovation and resource development for the system, introducing new products (e.g., gene trap ES cells) and initiating new services (e.g., blastocyst injection, ICSI) that have added scientific value to mouse models and enhanced utilization of the MMRRC by researchers. UCD-MMRRC has leveraged its infrastructure and expertise to extend its service role by contracting with NIH institutes, biotechnology companies, and several organizations to archive, distribute, custom breed, genotype, and phenotype 1000's of additional ES cell mutants, BAC-transgenic, CRE, ENU-induced, and other mutant mouse collections. In addition, we have worked with the Centers and NIH program staff and developed and implemented advertising and marketing strategies, database management and informatics applications, website and online resources, customer and user services, operating procedures and policies, and shared governance of the national program. PUBLIC HEALTH RELEVANCE (provided by applicant): The UCD-MMRRC serves a primary role in ensuring that valuable mouse models of human disease, development, and behavioral abnormalities created in research laboratories are shared broadly among the biomedical scientific community. As a regionally-distributed repository and distribution archive, the UCD- MMRRC provides expertise, infrastructure, resources and services to preserve mouse strains in perpetuity, protect them from catastrophic loss, avoid genetic and phenotypic drift, and prevent pathogenic contamination and disease. By enabling availability and access of such valuable mouse models to the entire research community, the UCD-MMRRC fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 描述（由申请人提供）：该提案旨在为基础设施，人员和资源提供竞争性的资金，以支持加利福尼亚大学戴维斯大学（UCD-MMRRC）的MMRRC。 UCD-MMRRC与密苏里大学 - 哥伦比亚大学和北卡罗来纳大学 - 教堂山的2个中心以及杰克逊实验室的信息学，协调和服务中心（ICSC）一起充当MMRRC国家计划的分销档案和数据中心。自10年前成立以来，UCD-MMRRC一直是世界上主要的突变小鼠档案和分配存储库之一。我们是三个中心的最大档案，库存的28,500多个突变型小鼠系，约占系统中所有活菌落，种质和/或胚胎茎（ES）细胞的98％。 UCD-MMRRC已履行了30个国家 /地区500个机构的2000多家调查人员的近6000个订单。我们还一直是该系统创新和资源开发的领导者，引入了新产品（例如，基因诱捕ES细胞），并启动了新服务（例如，胚泡注入，ICSI）为小鼠模型增加了科学价值，并增强了研究人员的MMRRC利用率。 UCD-MMRRC利用其基础架构和专业知识来通过与NIH机构，生物技术公司和几个组织签约来扩展其服务作用，以归档，分发，定制品种，基因型和表型1000的其他ES ES细胞突变体，BAC-TRANSGENIC，CRE，ENU，ENU，ENU，ENU，ENU诱导的突变型突变型和其他Mutant Mutant鼠标收集。此外，我们还与中心和NIH计划人员合作，制定并实施了广告和营销策略，数据库管理和信息学应用程序，网站和在线资源，客户和用户服务，操作程序和政策以及对国家计划的共同治理。 公共卫生相关性（由申请人提供）：UCD-MMRRC在确保在研究实验室中造成的人类疾病，发展和行为异常的宝贵小鼠模型在生物医学科学社区中广泛共享。作为区域分配的存储库和分配存档，UCD-MRRC提供了专业知识，基础设施，资源和服务，以保存永久性小鼠菌株，保护它们免受灾难性损失，避免遗传和表型漂移，并防止致病性和疾病。通过启用和访问此类宝贵的鼠标模型，向整个研究界，UCD-MMRRC养育者促进并促进发现新的诊断，治疗方法和预防人类疾病的策略。