Mouse Production, Testing, and Research Support Core

鼠标生产、测试和研究支持核心

基本信息

批准号：
10398861
负责人：
KC KENT LLOYD
金额：
$ 46.4万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10398861
关键词：
Accreditation Alzheimer&apos s Disease Autopsy Bioinformatics Biology Biometry Blood Blood specimen Brain Breeding Caring Cognitive Containment Data Diet Disease Surveillance Electrophysiology (science)Ensure Faculty Female Future Genotype Goals Harvest Health Healthcare Individual Infrastructure Intervention Investigation Ketosis Label Leadership Liquid substance Longevity Methods Monitor Mus Phenotype Production Readiness Research Research Project Grants Research Support Resources Sampling Schedule Scientist Services Structure Technical Expertise Testing Therapeutic Tissue Preservation Translations Update Wild Type Mouse Work aged authority behavioral phenotyping clinical application cohort cost experience male metabolic phenotype mouse model mutant neurobehavioral neurochemistry neuropathology operation phenotypic data preclinical study programs ranpirnase sample collection

Accreditation Alzheimer&apos s Disease Autopsy Bioinformatics Biology Biometry Blood Blood specimen Brain Breeding Caring Cognitive Containment Data Diet Disease Surveillance Electrophysiology (science)Ensure Faculty Female Future Genotype Goals Harvest Health Healthcare Individual Infrastructure Intervention Investigation Ketosis Label Leadership Liquid substance Longevity Methods Monitor Mus Phenotype Production Readiness Research Research Project Grants Research Support Resources Sampling Schedule Scientist Services Structure Technical Expertise Testing Therapeutic Tissue Preservation Translations Update Wild Type Mouse Work aged authority behavioral phenotyping clinical application cohort cost experience male metabolic phenotype mouse model mutant neurobehavioral neurochemistry neuropathology operation phenotypic data preclinical study programs ranpirnase sample collection

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项目摘要

Project Summary – Mouse Production, Testing, and Research Support Core (Core C) Core C, the Mouse Production, Testing, and Research Support Core, will provide mice and mouse services for study in all four research projects proposed in this program project. Specifically, the Core will expand and manage breeding colonies of mutant and wildtype mice, provide husbandry and health care, administer test diets, and ensure the identity, availability, and accessibility of all mice that will be used for research. In addition, the Core will harvest, collect, label, record, and preserve tissue and fluid (e.g., blood, brain) samples from individual mice and deliver samples to the appropriate project(s) for analysis. Moreover, the Core will be responsible for conducting specific cognitive and behavioral phenotyping tests on mouse lines. Finally, the Core will provide expertise in preclinical studies using Alzheimer's disease mouse models and facilitate future translation to clinical applications. Data collected and recorded from these tests will be delivered to Core B, the Biostatistics and Bioinformatics Core and to the relevant research project(s) for analysis and interpretation, respectively. Core C will also work closely with Core A, the Administrative Core, to streamline and efficiently coordinate activities between all four research projects. With its technical and faculty expertise and committed program infrastructure, Core C is uniquely prepared to accomplish these objectives.

项目摘要 - 鼠标生产，测试和研究支持核心（核心C）核心C，鼠标的产生，测试和研究支持核心将提供小鼠和鼠标该计划项目提出的所有四个研究项目中的研究服务。具体而言，核心将扩展和管理突变体和野生型小鼠的繁殖菌落，提供饲养和医疗保健，管理测试饮食，并确保将用于研究。此外，核心将收获，收集，标记，记录和保存组织和液体（例如，血液，大脑）来自单个小鼠的样品，并将样品输送到适当的项目进行分析。而且，核心将负责在小鼠线上进行特定的认知和行为表型测试。最后，核心将使用阿尔茨海默氏病小鼠模型和促进将来转化为临床应用。从这些测试中收集和记录的数据将是交付给核心B，生物统计学和生物信息学核心以及相关研究项目分析和解释。核心C还将与行政核心A Core A紧密合作简化并有效地协调所有四个研究项目之间的活动。具有技术和教师 Core C的专业知识和坚定的计划基础架构已为实现这些目标做好了独特的准备。