Replacement of Pass Through Autoclave Sterilizer Within A High Health Status Barrier Vivarium- Building M3 UC Davis

更换高健康状况屏障 Vivarium- Building M3 UC Davis 内的通过式高压灭菌器

基本信息

批准号：
9120041
负责人：
KC KENT LLOYD
金额：
$ 49.94万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2018-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The M3 Targeted Genomics Facility Vivarium Housing unit is the only high health status barrier rodent housing facility on the University of California Davis (UC Davis) Campus and is in dire need of replacement of the facility dedicated bulk pass-through autoclave sterilizer. The biosecurity of the M3 barrier vivarium is dependent on the operational function of this critical piece of equipment which is over 40 years old and has been assessed and demonstrated to have irreparable damage which will lead to eminent equipment failure and subsequent facility operational failure jeopardizing the animal health and welfare of those animals housed within. The M3 facility supports 38 UC Davis investigators with active grant and internal campus support totaling approximately $10.5 million. All supplies, caging, bedding, feed, and bottles are autoclaved into the facility to ensure the strict health status of the genetically modified animals and immune compromised rodent colonies housed in the M3 barrier vivarium. The M3 barrier vivarium serves as the High health "vendor status barrier" for shipping associated with several large NIH funded grant repository projects (Mutant Mouse Resource and Research Center, Knockout Mouse Project Repository, and the Bariatric Surgical Model Distribution for the Mouse Metabolic Phenotyping Center). The M3 barrier housing facility also houses the campus colony which supplies all rodent sentinel animals for the UC Davis Campus Rodent Health Monitoring Program. Thus, the impact of the operations of the M3 barrier facility reach beyond the animals housed within the facility and affect all mouse related research across the UC Davis campus. The current autoclave is over 40 year old and has been used past its life expectancy. Damage from several years of inadequate steam supply due to lack of infrastructure development have led to cracks in the jacket of the autoclave which can't be repaired. Funds are being requested for replacement of the bulk pass through autoclave sterilizer as well as additional dedicated electric boiler support for the new equipment to prevent excessive wear and tear from inadequate central steam infrastructure. The new autoclave will be more energy efficient, water saving, and improve operational efficiency in order to support the growing use of the M3 Targeted Genomics Vivarium Facility. This will ensure the biosecurity, welfare, and health of current and future rodent projects reliant on the health status that this vivarium housing facility provides.

描述（由适用提供）：M3靶向基因组学设施Vivarium住房单元是加利福尼亚大学戴维斯大学（UC Davis）校园的唯一高健康状况屏障啮齿动物住房设施，直接需要更换专用的散装散装通行型自动启动灭菌器。 M3屏障的生物安全性取决于该关键设备的运行功能，该设备已有40多年的历史，并已被评估并被证明是无法弥补的损害，这将导致设备故障和随后的设施操作失败危害内部这些动物的动物健康和福利。 M3设施为38名UC Davis调查人员提供了活跃的Grant和Internal Campus的支持，总计约为1050万美元。将所有供应，笼子，床上用品，饲料和瓶子都供应到设施中，以确保在M3屏障Vivarium中容纳一般修饰的动物和免疫机构的啮齿动物菌落的严格健康状况。 M3屏障Vivarium是与几个大型NIH资助的赠款存储库项目（突变小鼠资源和研究中心，基因敲除小鼠项目存储库以及小鼠代谢表型中心的减肥手术模型分布）相关的运输的高健康“供应商状态障碍”。 M3屏障住房设施还设有校园殖民地，该校园殖民地为UC Davis校园啮齿动物啮齿动物健康监测计划提供了所有啮齿动物的动物。这是M3障碍设施的运营的影响，超出了设施内的动物，并影响整个UC Davis校园中的所有相关研究。当前的高压釜已有40多年的历史，并且已超过其预期寿命。由于缺乏基础设施的发展，蒸汽供应不足的损坏导致无法修复的高压板夹克裂缝。要求资金更换大量通过高压灭菌器以及对新设备的其他专用电动锅炉支撑，以防止中央蒸汽基础设施不足的磨损过多。新的高压灭菌器将更加节能，节水并提高运营效率，以支持日益增长的M3靶向基因组学生物设施的使用。这将确保当前和未来的啮齿动物项目的生物安全，福利和健康依赖于健康状况该Vivarium住房设施提供的。