NORTHWESTERN Alzheimer's Disease Research Center

西北阿尔茨海默病研究中心

• 批准号: 10662473
• 负责人: ROBERT J VASSAR
• 金额: $ 344.35万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662473
• 关键词: Accreditation; Address; Administrator; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Area; Autopsy; Award; Biological Markers; Biology; Biometry; Blood; Businesses; Clinical; Clinical Investigator; Cognitive aging; Collaborations; Consultations; DNA; Data; Dementia; Development; Disease; Early Diagnosis; Education; Educational Status; Ensure; Etiology; Extramural Activities; Faculty; Family; Fellowship; Frontotemporal Lobar Degenerations; Funding; Goals; Grant; Healthcare; Heterogeneity; Human Resources; Image; Individual; Institution; Intervention; Investments; Laboratories; Leadership; Life; Microglia; Modality; Names; Nerve Degeneration; Neuropsychology; Parents; Participant; Pathology; Pathway interactions; Patient Recruitments; Patients; Plasma; Play; Positron-Emission Tomography; Primary Progressive Aphasia; Research; Research Personnel; Research Priority; Research Support; Resources; Risk Factors; Role; Scientist; Slide; Standardization; Syndrome; Time; Tissue Sample; Tissues; Training; Training Programs; Training and Education; Translational Research; Underrepresented Populations; Underserved Population; United States; Universities; Work; aging brain; beneficiary; brain tissue; clinical diagnosis; cognitive neuroscience; cohort; data exchange; data management; design; diagnostic criteria; education research; imaging biomarker; innovation; interest; member; middle age; multidisciplinary; multimodal neuroimaging; neuroinflammation; neuropathology; novel; outreach; participant retention; programs; protein TDP-43; recruit; responsible research conduct; statistics; tau Proteins; translational approach

PROJECT SUMMARY - OVERALL COMPONENT The Northwestern ADRC is in its 25th year. This renewal application describes the progress of the past cycle and a plan of action for the next 5 years, during which we will pursue the following principal goals: 1) Support innovative research at Northwestern University on the biology, early diagnosis, risk factors, and treatment of dementias by bringing together basic and clinical investigators. 2) Participate in national collaborations that leverage the strengths of the NIA Centers by using the UDS-3 and FTLD Module and transmitting data to NACC, and participating in ADNI, ADCS, NCRAD, LOAD, ADGC, and FTLD-related consortia. 3) Serve a leadership role in FTLD neuropathology, primary progressive aphasia (PPA), dementias associated with TDP-43 pathology, mid-life onset AD (MOAD), microglia and neuroinflammation, and unusually successful brain aging (SuperAging) in keeping with the unique strengths of the Northwestern ADRC in this area of aging and dementia research. 4) Train fellows and junior faculty and attract new investigators to dementia research through accredited clinical fellowships, Development Project awards, and training grants. 5) Ensure that patients, families, and underserved populations are beneficiaries of relevant advances through education, outreach, and novel life enrichment programs. The cores of the ADRC are configured to serve the specific goals listed above. The Administrative Core will be responsible for the clinical, scientific and fiscal leadership of the entire ADRC, as well as the coordination with national consortia and the selection of Development Projects. The Clinical Core will maintain a cohort of well- characterized subjects recruited to address ongoing research priorities. The Data Management and Statistics Core will ensure that the data are stored in ways that maximize collaboration and that biostatistical consultation plays a key role in the design and interpretation of research. The Neuropathology Core will characterize patients who come to autopsy according to up-to-date criteria, and distribute tissue, slides, DNA, and data for local and national collaborations. The Outreach, Recruitment and Engagement Core will work with the Clinical Core to enhance participant recruitment and retention in the ADRC, and will develop innovative life enrichment programs to serve patients and their families. The Research Education Component will oversee diversity recruitment for researchers and junior faculty and coordinate training requirements for the Responsible Conduct of Research. The Imaging Biomarker Core will perform up-to-date multimodal neuroimaging of Clinical Core participants, including amyloid and tau PET. The Executive Committee, composed of all key personnel, will formulate ADRC priorities based on local and national mandates and will review requests for patients, controls, tissue, and data.

项目摘要 - 整体组件 西北ADRC已有25年。此更新应用描述了过去周期的进度 以及未来5年的行动计划，在此期间，我们将实现以下主要目标： 1）支持西北大学关于生物学，早期诊断，危险因素和 通过将基本和临床研究人员汇总在一起来治疗痴呆症。 2）参加通过使用UDS-3来利用NIA中心优势的国家合作 FTLD模块并将数据传输到NACC，并参与ADNI，ADC，NCRAD，LOAD， ADGC和FTLD相关的财团。 3）在FTLD神经病理学，初级进步性失语（PPA），痴呆症中发挥领导作用 与TDP-43病理学，中年发作AD（MOAD），小胶质细胞和神经炎症有关，以及 与西北地区的独特优势保持异常成功的大脑衰老（超级衰老） ADRC在衰老和痴呆研究领域。 4）火车研究员和初级教师，并通过认可的 临床奖学金，开发项目奖和培训补助金。 5）确保患者，家庭和服务不足的人群是相关进展的受益者 通过教育，外展和新颖的生活丰富计划。 ADRC的内核被配置为服务上述特定目标。行政核心将是 负责整个ADRC的临床，科学和财政领导，以及与 国家财团和开发项目的选择。临床核心将保持一系列良好 招募的主题是为了解决正在进行的研究重点。数据管理和统计数据 核心将确保数据以最大化协作和生物统计咨询方式存储 在研究和解释中起关键作用。神经病理学核心将表征 根据最新标准进行尸检的患者，并分配组织，幻灯片，DNA和数据 地方和国家合作。外展，招聘和参与核心将与临床合作 增强参与者在ADRC中的招聘和保留率的核心，并将发展创新的生活充实 为患者及其家人提供服务的计划。研究教育部分将监督多样性 招聘研究人员和初级教师和协调负责任的培训要求 进行研究。成像生物标志物核心将执行临床的最新多模式神经影像 核心参与者，包括淀粉样蛋白和Tau Pet。由所有关键人员组成的执行委员会， 将根据地方和国家任务来制定ADRC优先级，并将审查患者的请求， 对照，组织和数据。

项目成果

Broadening the identification of superior cognition in older age.

• DOI: 10.1055/s-0043-1764451
• 发表时间: 2023-02
• 期刊: ARQUIVOS DE NEURO-PSIQUIATRIA
• 影响因子: 1.4
• 作者: Rogalski, Emily

Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.

• DOI: 10.1001/jamaneurol.2023.1067
• 发表时间: 2023-06-01
• 期刊: JAMA NEUROLOGY
• 影响因子: 29
• 作者: Leuzy, Antoine;Binette, Alexa Pichet;Vogel, Jacob W.;Klein, Gregory;Borroni, Edilio;Tonietto, Matteo;Strandberg, Olof;Mattsson-Carlgren, Niklas;Palmqvist, Sebastian;Pontecorvo, Michael J.;Iaccarino, Leonardo;Stomrud, Erik;Ossenkoppele, Rik;Smith, Ruben;Hansson, Oskar
• 通讯作者: Hansson, Oskar

Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?

• DOI: 10.1002/trc2.12321
• 发表时间: 2022
• 期刊: ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
• 影响因子: 4.8
• 作者: Spencer, Barbara E;Banks, Sarah J;Dale, Anders M;Brewer, James B;Makowski-Woidan, Beth;Weintraub, Sandra;Mesulam, M-Marsel;Geula, Changiz;Rogalski, Emily
• 通讯作者: Rogalski, Emily

Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data.

• DOI: 10.1186/s13195-022-01056-x
• 发表时间: 2022-08-19
• 期刊: Alzheimer's research & therapy

Acceptability and Feasibility of a Socially Enhanced, Self-Guided, Positive Emotion Regulation Intervention for Caregivers of Individuals With Dementia: Pilot Intervention Study.

• DOI: 10.2196/46269
• 发表时间: 2023-09-06
• 期刊: JMIR AGING
• 影响因子: 4.9
• 作者: Kwok, Ian;Lattie, Emily Gardiner;Yang, Dershung;Summers, Amanda;Grote, Veronika;Cotten, Paul;Moskowitz, Judith Tedlie
• 通讯作者: Moskowitz, Judith Tedlie