Northwestern ADRC Non competing supplement application

西北 ADRC 非竞争性补充申请

• 批准号: 10577047
• 负责人: ROBERT J VASSAR
• 金额: $ 28.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577047
• 关键词: Administrative Supplement; Autopsy; Brain; Budgets; Chemicals; Clinical; Enrollment; Excision; Funding; Growth; Home; Hospital Departments; Hospitals; Inpatients; Medicine; Participant; Pathology; Patients; Physicians; Policies; Reagent; Research; Services; Shipping; Structure; Time; cost; hospice environment; neuropathology; pandemic disease; programs; ranpirnase; tissue processing

On behalf of the Northwestern ADRC, we are submitting this supplement application to request funding for expenses that were not requested in our P30 budget to support our brain autopsy program, because they were not required at the time of our initial application. As of January 2022, the Northwestern Memorial Hospital (NMH) Department of Pathology changed their billing policy for all hospital-incurred autopsies. Up to that date, all autopsies on any patient who was affiliated with a Northwestern Medicine physician were complimentary, including those obtained for the research participants enrolled in the Northwestern ADRC Clinical Core. All costs were covered including those for brain removal and storage and tissue processing. From January 2022 onward, this policy has changed such that free autopsies are provided only on those patients who expire while they are inpatients admitted to the hospital at NMH. Since most of our participants die at home or in hospice or at another hospital, we will require additional funding that was not requested in our prior applications, particularly in the last 5 year competing renewal, funded in 2021. As a result, the current application is requesting a supplement to cover the costs of brain autopsies carried out in the Department of Pathology at NMH for the Northwestern ADRC Clinical Core. Our Center estimates to conduct 50 brain autopsies per year at NMH. The request (see budget justification) includes the cost for brain removal and storage, tissue processing, and chemicals and reagents required for storage and processing. In addition, on occasion, our ADRC Neuropathology Core is asked to assist in brain removal for a participant at another ADRC who lives close to our facility. We are thus also asking for costs to cover brain removal, storage and shipping for those instances. Our brain autopsy program has been highly successful and even during the pandemic benefitted from the Department of Pathology's careful adjustments to allow safe brain removal of participants who have died since the pandemic began.

我们代表西北ADRC，我们提交此补充申请，要求提供资金 我们的P30预算中未要求的费用以支持我们的脑尸检计划，因为它们是 在我们初次申请时不需要。截至2022年1月，西北纪念医院 （NMH）病理部改变了其所有医院尸检的计费政策。到那个日期， 所有隶属于西北医学医师的患者的尸检都是免费的 包括为参加西北ADRC临床核心入学的研究参与者获得的。全部 涵盖了费用，包括用于清除大脑，存储和组织加工的成本。从2022年1月开始 此政策发生了变化，使得仅在那些到期的患者中提供免费尸检 他们是进入NMH医院的住院患者。由于我们大多数参与者在家中或在临终关怀中死亡或 在另一家医院，我们将需要其他申请中未要求的额外资金， 特别是在过去5年的竞争续约中，于2021年资助。结果，当前的申请是 请求补充剂以支付病理部在病理部门进行的大脑尸检费用 NMH用于西北ADRC临床核心。我们的中心估计每年进行50次大脑尸检 在NMH。请求（请参阅预算依据）包括清除和存储的费用，组织 加工以及存储和加工所需的化学品和试剂。此外，有时候，我们的 要求ADRC神经病理学核心协助另一名ADRC参与者的大脑清除 靠近我们的设施。因此，我们还要求为这些费用覆盖大脑清除，存储和运输的费用 实例。我们的脑尸检计划非常成功，甚至在大流行期间受益 来自病理学系的仔细调整，以允许安全地去除患有的参与者 自大流行以来就死了。