Systems Biology Core

系统生物学核心

基本信息

批准号：
10618820
负责人：
Arthur D Lander
金额：
$ 20.72万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-04-30
项目状态：
已结题

项目摘要

Systems Biology refers to the integration into biology of ideas and methodologies from mathematics, engineering, computer science, physics, and chemistry, with the goal of deriving greater understanding from data—especially data that are complex, dynamic and/or high-dimensional. Systems biology makes frequent use of explicit, quantitative models, and concerns itself both with how useful models can be derived from data as well as how models can be used to generate hypotheses and drive the collection of new data. Modern biological and biomedical research are becoming increasing reliant on systems biology approaches, yet because the skills and insights necessary to implement such approaches come from so many different disciplines, it can be challenging for researchers to take full advantage of them. The goal of the Systems Biology Core is to enable skin biology researchers to incorporate systems biology in their research, thereby enhancing productivity and increasing research impact. The core will help skin biologists derive more meaningful models from data; build and analyze explicit, quantitative models; use models to interpret, analyze, and integrate data (including data generated by other cores); use models to generate and prioritize testable hypotheses about function; and better understand and utilize literature that draws upon systems biology ideas and approaches. Methodologies to be made available through the Systems Biology Core are especially well suited to building upon data from, and providing input into, the efforts of the imaging and genomics/bioinformatics cores. Strategies for achieving these goals include targeted workshops for skin biologists, inclusion of skin biologists in an annual systems biology retreat, systems biology “clinics” at which skin biologists identify problems in need of attention, and individualized consultation. These strategies leverage the expertise and resources of three systems biology faculty with expertise in modeling and data analysis; long-standing experience in teaching interdisciplinary science; and a track-record of collaboration with skin biologists. It also leverages the infrastructure of a large campus-wide center devoted to systems biology, the Center for Complex Biological Systems.

系统生物学是指将数学思想和方法论融入生物学，工程学、计算机科学、物理和化学，目的是获得更好的理解数据——尤其是复杂、动态和/或高维的数据。使用明确的定量模型，并关注如何从数据中导出有用的模型以及如何使用模型来生成假设并推动新数据的收集。现代生物学和生物医学研究越来越依赖系统生物学方法，然而，因为实施这些方法所需的技能和见解来自许多不同的领域学科，研究人员充分利用它们可能具有挑战性系统的目标。 Biology Core 旨在使皮肤生物学研究人员能够将系统生物学纳入他们的研究中，从而提高生产力并增加研究影响力将帮助皮肤生物学家获得更多成果。从数据中建立有意义的模型；建立和分析明确的定量模型；并集成数据（包括其他核心生成的数据）；使用模型来生成可测试的数据并确定其优先级关于功能的假设；以及更好地理解和利用借鉴系统生物学思想的文献通过系统生物学核心提供的方法学特别好。适合于建立成像和成像工作的数据并为其提供输入基因组学/生物信息学核心。实现这些目标的策略包括为皮肤生物学家举办有针对性的研讨会、将皮肤生物学家在一年一度的系统生物学静修会上，系统生物学“诊所”，皮肤生物学家在其中识别这些策略利用了专业知识和经验。三位具有长期建模和数据分析专业知识的系统生物学教师的资源；教授跨学科科学的经验；以及与皮肤生物学家的合作记录。利用致力于系统生物学的大型校园中心的基础设施，复杂的中心生物系统。