A National Short Course in Systems Biology: Tackling Spatial Dynamics in Cells an

系统生物学国家短期课程：解决细胞中的空间动力学和

• 批准号: 8310057
• 负责人: Arthur D Lander
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8310057
• 关键词: Address; Area; Behavior; Bioinformatics; Biological; Biology; Biometry; California; Cell Differentiation process; Cell physiology; Cells; Complex; Computer Simulation; Computer software; Computing Methodologies; Data Set; Databases; Development; Discipline; Disease; Educational workshop; Environment; Faculty; Fluorescence; Fostering; Funding; Genomics; Goals; Grant; Health; Human; Human Development; Individual; Industry; Institutes; Instruction; Laboratories; Learning; Malignant Neoplasms; Morphogenesis; NIH Program Announcements; Online Systems; Participant; Pattern; Process; Property; Recruitment Activity; Research; Research Personnel; Research Training; Resources; Science; Scientist; Senior Scientist; Signal Transduction; Site; Software Tools; Spectrum Analysis; System; Systems Biology; Tissues; Training; United States National Institutes of Health; Universities; Video Recording; age related; biological systems; biomedical scientist; complex biological systems; computerized tools; design; disease transmission; experience; field study; graduate student; infectious disease model; interest; lectures; meetings; member; outreach; prevent; programs; skills; tool; tumor progression; working group; Address; Area; Behavior; Bioinformatics; Biological; Biology; Biometry; California; Cell Differentiation process; Cell physiology; Cells; Complex; Computer Simulation; Computer software; Computing Methodologies; Data Set; Databases; Development; Discipline; Disease; Educational workshop; Environment; Faculty; Fluorescence; Fostering; Funding; Genomics; Goals; Grant; Health; Human; Human Development; Individual; Industry; Institutes; Instruction; Laboratories; Learning; Malignant Neoplasms; Morphogenesis; NIH Program Announcements; Online Systems; Participant; Pattern; Process; Property; Recruitment Activity; Research; Research Personnel; Research Training; Resources; Science; Scientist; Senior Scientist; Signal Transduction; Site; Software Tools; Spectrum Analysis; System; Systems Biology; Tissues; Training; United States National Institutes of Health; Universities; Video Recording; age related; biological systems; biomedical scientist; complex biological systems; computerized tools; design; disease transmission; experience; field study; graduate student; infectious disease model; interest; lectures; meetings; member; outreach; prevent; programs; skills; tool; tumor progression; working group

DESCRIPTION (provided by applicant): This proposal aims to establish a National Short Course in Systems Biology that integrates mathematical, statistical and computational approaches to describe biological systems and understand their complex behaviors. The Center for Complex Biological Systems (CCBS) at UC Irvine is ideally suited to host this annual course being one of ten NIH National Centers for Systems Biology. The CCBS is able to leverage substantial faculty educational and research expertise - from a pool of more than 100 active faculty from 18 participating science departments, as well as contributions from preeminent resource facilities such as the Laboratory of Fluorescence Dynamics (LFD) and the Institute for Genomics and Bioinformatics - to create a top-rated training course designed for senior graduate students, postdoctoral researchers, faculty and industry scientists from diverse scientific disciplines who have nascent interests in engaging in Systems Biology research. The course theme will focus on the systems biology of spatial dynamics that impacts key cellular processes including signal transduction networks, cell differentiation, and developmental mechanisms of morphogenesis and patterning. Moreover, experience gained in these systems will enable trainees to apply these skills more generally to other complex systems with spatially dynamic properties. Recruitment and training of research scientists in this thematic area is currently underserved but demand is expected to be significant given the central importance of these processes to many human health related issues, including developmental abnormalities, age-related disease processes, initiation and progression of cancer and infectious disease models that are amenable to systems-oriented analysis and dependent on spatio-temporal factors. The course format will combine didactic lectures with hands-on practical laboratories featuring both biological experimentation and mathematical/computational modeling tutorials. The course design is organized into two principal sections: an optional 1-week Introductory Preparatory Workshop (either in Biology or Mathematical/ Computational Methods) will address individual trainee educational weaknesses by providing essential cross-disciplinary foundational instruction. The second part consists of a 2-week Systems Biology Core Course offering a high-level introduction to spatially dynamic research topics and advanced analytical biometric tools (e.g. advanced correlation spectroscopy and pipeline queries to bioinformatic databases) through project oriented instruction and small group interactions. This unique approach of addressing specific trainee educational deficiencies first, then building strong interdisciplinary collaborative work groups, will enhance course recruitment and entry into this field to research scientists who frequently feel interested but intimidated due to a perceived lack of prior formal training. Beyond providing an intensive on-site training course, all lecture materials (video recorded), training datasets, and software tools will be made freely available through on-line distribution to maximize our outreach efforts.

描述（由申请人提供）：该提案旨在建立系统生物学的全国短期课程，该课程整合数学，统计和计算方法，以描述生物系统并了解其复杂行为。 UC Irvine的复杂生物系统（CCB）中心非常适合举办该年度课程，是十个NIH国家系统生物学中心之一。 CCB能够利用实质的教师教育和研究专业知识 - 从来自18个参与科学部门的100多名积极教师以及杰出的资源设施的贡献，例如荧光动态实验室（LFD），以及为基因组学和生物信息学研究所提供的高级培训研究者，以创建高级培训的研究员，以创建高级研究生，以创建高级研究生，并提供高级研究生的研究。对从事系统生物学研究具有新生兴趣的科学学科。该课程主题将集中在空间动力学的系统生物学上，这些动力学影响关键的细胞过程，包括信号转导网络，细胞分化以及形态发生和模式的发育机制。此外，在这些系统中获得的经验将使受训者能够更普遍地将这些技能应用于具有空间动态特性的其他复杂系统。目前，在这个主题领域的研究科学家对研究科学家的招聘和培训目前服务不足，但鉴于这些过程对许多与人类健康相关的问题的重要性，包括发育异常，与年龄相关的疾病过程，癌症的起始和癌症的启动和传染病模型，这些模型与系统分析和依赖于空间级别的因素相关，因此需求是显着的。该课程格式将结合教学讲座和动手实践实验室，具有生物学实验和数学/计算建模教程。该课程设计分为两个主要部分：可选的1周入门预备研讨会（在生物学或数学/计算方法中）将通过提供基本的跨学科基础教学来解决各个受训者的教育弱点。第二部分由为期2周的系统生物学核心课程组成，该课程提供了关于空间动态研究主题和高级分析生物识别工具的高级介绍（例如先进的相关光谱和管道查询，通过项目面向的指导和小组相互作用和小组相互作用。这种独特的方法是首先解决特定的受训者教育缺陷，然后建立强大的跨学科合作工作组，将增强课程招聘并进入该领域，以使他们经常感到兴趣但由于缺乏以前的正式培训而受到威胁的研究科学家。除了提供密集的现场培训课程外，还将通过在线分发免费提供所有讲座材料（视频记录），培训数据集和软件工具，以最大程度地提高我们的外展工作。