Mathematical, Computational and Systems Biology

数学、计算和系统生物学

• 批准号: 10642829
• 负责人: Arthur D Lander
• 金额: $ 36.19万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642829
• 关键词: Computational Biology; Mathematical Biology; Systems Biology

Program Summary/Abstract In recent years, new demands are being placed on biomedical researchers and clinicians thanks to changes in the way we acquire, analyze and interact with data. Many areas of biomedical science are transitioning from being data-poor and hypothesis-rich to extremely data-rich and (comparatively) hypothesis-poor. Conducting rigorous research in this new environment can be challenging, as it requires grounding not just in biology, but also in mathematics, computation and statistics. This application requests support for a pre-doctoral training program designed to produce Ph.D.s with sufficient skills in fundamental biology, mathematical and computational modeling, and data science to attack these challenges head on. The program is built upon a free-standing, interdisciplinary Ph.D. program that has been developed and refined over the past dozen years, and offers training at the interface between the biological sciences and mathematics, computer science, physics and engineering. Eight pre- doctoral trainee slots are requested, for appointments intended to last two years each. Highlights of the proposed program include an extensive didactic curriculum; a focus on critical thinking skills; an emphasis on collaboration and collaborative learning; close mentoring, opportunities to develop multiple career skills; and active student involvement. The 31 program faculty members come from 14 different departments in five schools at the University of California, Irvine, and conduct research on diverse topics within biology and medicine. The program enjoys strong campus support, and an administrative and intellectual home within the UCI Center for Complex Biological Systems, a National Center for Systems Biology with a long- standing commitment to promoting interdisciplinary education at all academic levels. The proposed program will prepare trainees for careers in biomedical research, teaching, and communication in both academic and non-academic settings.

计划摘要/摘要 近年来，对生物医学研究人员和临床医生提出了新的要求 由于我们获取、分析数据以及与数据交互的方式发生了变化。许多领域 生物医学科学正在从数据匮乏和假设丰富转变为极其 数据丰富但（相对而言）假设贫乏。在这个新领域进行严格的研究 环境可能具有挑战性，因为它不仅需要生物学基础，还需要基础知识 数学、计算和统计学。此申请请求支持博士前 旨在培养具有足够基础生物学技能的博士学位的培训计划， 数学和计算建模以及数据科学来应对这些挑战 在。该计划建立在独立的跨学科博士学位之上。已经有的程序 经过过去十几年的发展和完善，并提供了之间接口的培训 生物科学和数学、计算机科学、物理和工程学。八预 要求博士生实习生名额，每次任命的期限为两年。 拟议项目的亮点包括广泛的教学课程；注重批评 思维能力；强调协作和协作学习；密切指导， 发展多种职业技能的机会；和学生的积极参与。 31个节目 教职员工来自大学五个学院的 14 个不同院系 加利福尼亚州欧文市，并对生物学和医学领域的不同主题进行研究。这 该计划享有强大的校园支持，以及在该项目内的行政和知识之家 UCI 复杂生物系统中心，国家系统生物学中心，拥有长期 长期致力于促进所有学术层面的跨学科教育。这 拟议的计划将为学员提供生物医学研究、教学和职业生涯的准备 学术和非学术环境中的沟通。

项目成果

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.

• DOI: 10.1016/j.celrep.2022.110775
• 发表时间: 2022-05-03
• 期刊: CELL REPORTS
• 影响因子: 8.8
• 作者: Tian, Guilian;Hui, May;Macchia, Desiree;Derdeyn, Pieter;Rogers, Alexandra;Hubbard, Elizabeth;Liu, Chengfeng;Vasquez, Jose J.;Taniguchi, Lara;Bartas, Katrina;Carroll, Sean;Beier, Kevin T.
• 通讯作者: Beier, Kevin T.

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

• DOI: 10.1016/j.jid.2023.03.1679
• 发表时间: 2023-09
• 期刊: The Journal of investigative dermatology
• 作者: A. Almet;Hao Yuan;Karl Annusver;Raul Ramos;Yingzi Liu;J. Wiedemann;Dara H. Sorkin;N. Landén;E. Sonkoly;M. Haniffa;Qing Nie;B. Lichtenberger;Malte D. Luecken;B. Andersen;L. Tsoi;F. Watt;J. Gudjonsson;M. Plikus;M. Kasper

Uncovering the Connectivity Logic of the Ventral Tegmental Area.

• DOI: 10.3389/fncir.2021.799688
• 发表时间: 2021
• 期刊: Frontiers in neural circuits
• 影响因子: 3.5
• 作者: Derdeyn P;Hui M;Macchia D;Beier KT
• 通讯作者: Beier KT

Reanalysis of primate brain circadian transcriptomics reveals connectivity-related oscillations.

• DOI: 10.1016/j.isci.2023.107810
• 发表时间: 2023-10-20
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Lee, Justine;Chen, Siwei;Monfared, Roudabeh Vakil;Derdeyn, Pieter;Leong, Kenneth;Chang, Tiffany;Beier, Kevin;Baldi, Pierre;Alachkar, Amal
• 通讯作者: Alachkar, Amal

Mapping and modeling the genomic basis of differential RNA isoform expression at single-cell resolution with LR-Split-seq.

• DOI: 10.1186/s13059-021-02505-w
• 发表时间: 2021-10-07
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Rebboah E;Reese F;Williams K;Balderrama-Gutierrez G;McGill C;Trout D;Rodriguez I;Liang H;Wold BJ;Mortazavi A
• 通讯作者: Mortazavi A