Mathematical, Computational and Systems Biology

数学、计算和系统生物学

• 批准号: 10642829
• 负责人: Arthur D Lander
• 金额: $ 36.19万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642829
• 关键词: Computational Biology; Mathematical Biology; Systems Biology

Program Summary/Abstract In recent years, new demands are being placed on biomedical researchers and clinicians thanks to changes in the way we acquire, analyze and interact with data. Many areas of biomedical science are transitioning from being data-poor and hypothesis-rich to extremely data-rich and (comparatively) hypothesis-poor. Conducting rigorous research in this new environment can be challenging, as it requires grounding not just in biology, but also in mathematics, computation and statistics. This application requests support for a pre-doctoral training program designed to produce Ph.D.s with sufficient skills in fundamental biology, mathematical and computational modeling, and data science to attack these challenges head on. The program is built upon a free-standing, interdisciplinary Ph.D. program that has been developed and refined over the past dozen years, and offers training at the interface between the biological sciences and mathematics, computer science, physics and engineering. Eight pre- doctoral trainee slots are requested, for appointments intended to last two years each. Highlights of the proposed program include an extensive didactic curriculum; a focus on critical thinking skills; an emphasis on collaboration and collaborative learning; close mentoring, opportunities to develop multiple career skills; and active student involvement. The 31 program faculty members come from 14 different departments in five schools at the University of California, Irvine, and conduct research on diverse topics within biology and medicine. The program enjoys strong campus support, and an administrative and intellectual home within the UCI Center for Complex Biological Systems, a National Center for Systems Biology with a long- standing commitment to promoting interdisciplinary education at all academic levels. The proposed program will prepare trainees for careers in biomedical research, teaching, and communication in both academic and non-academic settings.

程序摘要/摘要 近年来，对生物医学研究人员和临床医生提出了新的要求 由于我们获取，分析和与数据互动的方式发生了变化。许多领域 生物医学科学正在从数据贫困和假设过渡到极端 数据丰富和（比较）贫困。在这个新的 环境可能具有挑战性，因为它不仅需要生物学，而且需要在 数学，计算和统计。该申请要求支持预期前 旨在生产具有足够技能的基本生物学技能的培训计划， 数学和计算建模以及攻击这些挑战的数据科学负责人 在。该计划建立在独立的跨学科博士学位上。已经过去了 在过去的十几年中，开发和完善了，并在 生物科学和数学，计算机科学，物理和工程。八个 请求博士培训老虎机，以期约会持续两年。 该计划的亮点包括广泛的教学课程；专注于批判 思维技能；强调协作和协作学习；亲密指导， 发展多种职业技能的机会；和积极的学生参与。 31个程序 教职员工来自大学的五所学校的14个不同系 加利福尼亚州，尔湾（Irvine）并对生物学和医学中的各种主题进行研究。这 计划享有强大的校园支持，以及内部的行政和知识分子 UCI复杂生物系统中心，国家系统生物学中心，长期 在所有学术层面上促进跨学科教育的坚定承诺。这 拟议的计划将为受训者准备生物医学研究，教学和 在学术和非学术环境中进行交流。

项目成果

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.

• DOI: 10.1016/j.celrep.2022.110775
• 发表时间: 2022-05-03
• 期刊: CELL REPORTS
• 影响因子: 8.8
• 作者: Tian, Guilian;Hui, May;Macchia, Desiree;Derdeyn, Pieter;Rogers, Alexandra;Hubbard, Elizabeth;Liu, Chengfeng;Vasquez, Jose J.;Taniguchi, Lara;Bartas, Katrina;Carroll, Sean;Beier, Kevin T.
• 通讯作者: Beier, Kevin T.

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

• DOI: 10.1016/j.jid.2023.03.1679
• 发表时间: 2023-09
• 期刊: The Journal of investigative dermatology
• 作者: A. Almet;Hao Yuan;Karl Annusver;Raul Ramos;Yingzi Liu;J. Wiedemann;Dara H. Sorkin;N. Landén;E. Sonkoly;M. Haniffa;Qing Nie;B. Lichtenberger;Malte D. Luecken;B. Andersen;L. Tsoi;F. Watt;J. Gudjonsson;M. Plikus;M. Kasper

Uncovering the Connectivity Logic of the Ventral Tegmental Area.

• DOI: 10.3389/fncir.2021.799688
• 发表时间: 2021
• 期刊: Frontiers in neural circuits
• 影响因子: 3.5
• 作者: Derdeyn P;Hui M;Macchia D;Beier KT
• 通讯作者: Beier KT

Reanalysis of primate brain circadian transcriptomics reveals connectivity-related oscillations.

• DOI: 10.1016/j.isci.2023.107810
• 发表时间: 2023-10-20
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Lee, Justine;Chen, Siwei;Monfared, Roudabeh Vakil;Derdeyn, Pieter;Leong, Kenneth;Chang, Tiffany;Beier, Kevin;Baldi, Pierre;Alachkar, Amal
• 通讯作者: Alachkar, Amal

Mapping and modeling the genomic basis of differential RNA isoform expression at single-cell resolution with LR-Split-seq.

• DOI: 10.1186/s13059-021-02505-w
• 发表时间: 2021-10-07
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Rebboah E;Reese F;Williams K;Balderrama-Gutierrez G;McGill C;Trout D;Rodriguez I;Liang H;Wold BJ;Mortazavi A
• 通讯作者: Mortazavi A