Core G: Neuroimaging Core

核心 G：神经影像核心

• 批准号: 10473835
• 负责人: DOUGLAS C NOLL
• 金额: $ 43万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473835
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-Protein; Autopsy; Basic Science; Biological Markers; Blood Vessels; Clinical; Clinical Markers; Clinical Research; Collaborations; Consult; Consultations; Data; Deposition; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Progression; Early Diagnosis; Education; Educational workshop; Ensure; Functional Magnetic Resonance Imaging; Gold; Health; Hippocampus (Brain); Image; Imaging Device; Instruction; Iron; Laboratories; Lead; Lesion; Link; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Methods; Michigan; Modality; Modeling; Monitor; Myelin; Nerve Degeneration; Participant; Pathology; Peripheral; Physics; Positron-Emission Tomography; Predisposition; Protocols documentation; Research; Research Personnel; Schedule; Scientist; Site; Source; Staging; Standardization; Testing; Tissues; Tracer; Training; Universities; Validation; Water; Work; arterial spin labeling; biomarker validation; data management; design; education research; eligible participant; flexibility; image archival system; image processing; imaging biomarker; longitudinal analysis; meetings; morphometry; multimodality; neuroimaging; neuropathology; next generation; novel; novel marker; rapid growth; recruit; tau Proteins; tool

ABSTRACT – CORE G: NEUROIMAGING CORE The overall objectives of the Neuroimaging Core (NIC) are to provide and integrate state-of-the-art, standardized MRI and PET imaging measures for Michigan Alzheimer’s Disease Research Center (MADRC) participants, work with both internal and external stakeholders to evaluate and deploy novel imaging biomarkers, and engage in collaborations, consultation and educational efforts to maximize the utility of these measures. The NIC will acquire longitudinal structural and functional MRI on all eligible MADRC participants using consistent imaging devices and providing flexible scheduling to assist in recruiting non-local participants. The NIC will also provide access to tau and amyloid PET protocols and quantitation. The NIC will provide standardized image processing (e.g. morphometry, connectivity, lesion measures) and, in coordination with the Data Management and Statistical Core (DMSC), maintain an internal archive of imaging data that can be accessed by all MADRC researchers. The NIC will also study and validate novel imaging biomarkers using MRI, including myelin-water fraction (MWF), iron accumulation using quantitative susceptibility mapping, microstructural modeling using diffusion MRI, hippocampus subfield volumetry, and vascular pathology. The NIC will collaborate with the Clinical Core to coordinate and facilitate imaging of MADRC participants, and work with the DMSC to provide access to imaging data locally and nationally, including summary measures from neuroimaging data, and collaborate with the Biomarker Core on biomarker validation. The NIC will consult with new and existing investigators on the design of neuroimaging studies, making use of standardized imaging protocols whenever possible. We will also provide consultation on novel imaging biomarkers as they are deployed. Finally, we will work with the Research Education Component to provide didactic and hands-on training related to MRI and PET acquisition and analyses. Through these efforts, the NIC will provide high quality non-invasive neuroimaging data to facilitate early diagnosis, prediction, and monitoring of disease progression, providing a rich source of data beyond traditional clinical markers.

摘要 – 核心 G：神经影像核心 神经影像核心 (NIC) 的总体目标是提供和集成最先进的、 密歇根阿尔茨海默病研究中心 (MADRC) 的标准化 MRI 和 PET 成像测量 与内部和外部利益相关者合作评估和部署新颖的成像 生物标志物，并参与合作、咨询和教育工作，以最大限度地利用这些 NIC 将对所有符合资格的 MADRC 参与者进行纵向结构和功能 MRI 扫描。 使用一致的成像设备并提供灵活的时间安排来协助招募非本地参与者。 NIC 还将提供 tau 蛋白和淀粉样蛋白 PET 协议和定量服务。 标准化图像处理（例如形态测定、连通性、病变测量），并与 数据管理和统计核心 (DMSC)，维护成像数据的内部档案，可以 NIC 还将使用所有 MADRC 研究人员访问和验证新型成像生物标志物。 MRI，包括髓磷脂-水分数 (MWF)、使用定量磁化率图的铁积累， 使用扩散 MRI、海马亚场体积法和血管病理学进行微观结构建模。 NIC 将与临床核心合作，协调和促进 MADRC 参与者的成像，并开展工作 与 DMSC 合作，提供本地和全国成像数据的访问，包括来自 神经影像数据，并与生物标记核心合作进行生物标记验证。 新的和现有的研究人员利用标准化成像来设计神经影像学研究 只要有可能，我们还将提供有关新型成像生物标志物的咨询。 最后，我们将与研究教育部门合作提供教学和实践。 通过这些努力，NIC 将提供与 MRI 和 PET 采集和分析相关的培训。 高质量的非侵入性神经影像数据，以促进疾病的早期诊断、预测和监测 进展，提供超越传统临床标志物的丰富数据源。