MRI Parallel Excitation for Neuroimaging Applications

用于神经影像应用的 MRI 并行激励

• 批准号: 7758259
• 负责人: DOUGLAS C NOLL
• 金额: $ 60.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7758259
• 关键词: Address; Air; Alcohols; Amplifiers; Automobile Driving; Biomedical Engineering; Blood; Brain; Brain Part; Brain Stem; Brain region; Clinical; Deposition; Detection; Development; Disease; Effectiveness; Epilepsy; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hyperactive behavior; Image; Imaging Device; Imaging technology; Inferior; Investigation; Lead; Leg; Magnetic Resonance Imaging; Magnetism; Medial; Methods; Michigan; Monitor; Morphologic artifacts; Neurodegenerative Disorders; Obsessive-Compulsive Disorder; Patients; Pattern; Performance; Physiologic pulse; Play; Population; Predisposition; Process; Protocols documentation; Research; Research Personnel; Resolution; Role; Signal Transduction; Simulate; Sinus; Slice; Software Validation; Source; Speed; Structure; System; Systems Integration; Techniques; Technology; Temporal Lobe; Testing; Texas; Time; Universities; absorption; brain tissue; cost; design; design and construction; flexibility; frontal lobe; frontal sinus; improved; interest; magnetic field; multidisciplinary; neuroimaging; neuropsychiatry; new technology; novel; novel strategies; patient population; prevent; programs; radiofrequency; simulation; technology development; technology validation; voltage

DESCRIPTION (provided by applicant): A Bioengineering Research Partnership (PAR-06-459) is proposed for the development of parallel excitation technology to improve functional magnetic resonance imaging (fMRI) studies in the inferior frontal cortex. This project is motivated by the need to eliminate large signal voids and image distortions caused by magnetic susceptibility differences between brain tissue and air in the nasal sinuses. These artifacts are ubiquitous in fMRI, especially for many inferior brain structures including the orbitofrontal cortex (OFC), inferior and medial temporal lobes, and brain stem structures. These parts of the brain have been implicated in neurodegenerative disorders, epilepsy, psychiatric conditions and alcohol/substance abuse disorders. Many current techniques to remove these distortions have a large cost in terms of temporal resolution or sensitivity for detection of activation. Our group has pioneered methods for reducing these artifacts, including multidimensional selective excitation, a technique that is promising, but is currently limited in the degree of correction and by the long duration of the excitation pulses. Parallel excitation is a new technology that will allow for greater flexibility in exciting specific patterns or more uniform patterns in MRI through the use of multiple independent excitation channels. For multidimensional excitation patterns, such as those used to eliminate the signal-loss artifacts in inferior brain regions in fMRI, parallel excitation should allow shorter pulses and offer more complete correction. This project is uniquely multidisciplinary in that it involves advances in parallel excitation pulse design, parallel excitation hardware, system integration, and application to studies of patients. This project will be lead by a multidisciplinary group of investigators: the Lead Investigators for this project are Douglas Noll (PI; System Integration and Software, Validation), Jeffrey Fessler (Pulse Optimization), and Stephen Taylor (Patient Studies); all from Univ. of Michigan and Steven Wright (Co-PI; Hardware, System Integration) from Texas A&M University. This project offers novel optimization strategies to parallel excitation pulse design, unique current source technologies for driving the parallel transmit array, and important scientific investigation into the functioning of the OFC. Together, these approaches lead to valuable new methods for functional MRI that are capable of probing inferior brain structures with sensitivity equal to other structures, which will aid in the study of a variety of neuropsychiatric disorders. The parallel excitation technology developed here will also advance the general state of MRI technology for correction of excitation inhomogeneity at high magnetic fields and for many other application of multidimensional excitation in MRI.

描述（由申请人提供）：提议建立生物工程研究合作伙伴关系（PAR-06-459），以开发并行激励技术，以改进下额皮质的功能磁共振成像（fMRI）研究。该项目的动机是需要消除由于脑组织和鼻窦中空气之间的磁化率差异引起的大信号空洞和图像失真。这些伪影在功能磁共振成像中普遍存在，特别是对于许多下脑结构，包括眶额皮质 (OFC)、下颞叶和内侧颞叶以及脑干结构。大脑的这些部分与神经退行性疾病、癫痫、精神疾病和酒精/药物滥用障碍有关。当前许多消除这些失真的技术在时间分辨率或激活检测的灵敏度方面代价高昂。我们的小组开创了减少这些伪影的方法，包括多维选择性激励，这是一种很有前途的技术，但目前在校正程度和激励脉冲的长持续时间方面受到限制。并行激励是一项新技术，通过使用多个独立的激励通道，可以更灵活地激励 MRI 中的特定模式或更均匀的模式。对于多维激励模式，例如用于消除功能磁共振成像中下脑区域信号丢失伪影的模式，并行激励应该允许更短的脉冲并提供更完整的校正。该项目是独特的多学科项目，因为它涉及并行激励脉冲设计、并行激励硬件、系统集成以及在患者研究中的应用方面的进展。该项目将由多学科研究人员小组领导：该项目的首席研究人员包括 Douglas Noll（PI；系统集成和软件、验证）、Jeffrey Fessler（脉冲优化）和 Stephen Taylor（患者研究）；全部来自大学。密歇根大学教授和来自德克萨斯 A&M 大学的 Steven Wright（联合 PI；硬件、系统集成）。该项目为并行激励脉冲设计提供新颖的优化策略、用于驱动并行发射阵列的独特电流源技术以及对 OFC 功能的重要科学研究。总之，这些方法带来了有价值的功能性 MRI 新方法，能够以与其他结构相同的灵敏度探测下脑结构，这将有助于研究各种神经精神疾病。这里开发的并行激励技术还将推进 MRI 技术的总体发展，用于校正高磁场下的激励不均匀性以及 MRI 中多维激励的许多其他应用。