OSTEOARTHRITIS AND PHYSICAL DISABILITY IN THE ELDERLY

老年人的骨关节炎和身体残疾

• 批准号: 3119234
• 负责人: DAVID Tobin FELSON
• 金额: $ 16.36万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3119234
• 关键词: body physical activity; case history; disabling disease; epidemiology; human old age (65+); knee; longitudinal human study; osteoarthritis; pain; sign /symptom

The overall goal of this project is to determine the impact of knee osteoarthritis (OA) on physical disability in the elderly. OA increases in prevalence at an age when elders experience deteriorating physical function, yet little is known about the functional impact of knee OA on the elderly. This study will examine that impact while controlling for other factors which affect disability such as age, marital status, living arrangements and medical comorbidities. The Framingham Heart Study cohort will be studied. This group offers several unique advantages in addressing this question: 1) it is a population-based cohort of elderly individuals (mean age 75); 2) knee OA was assessd clinically and radiographically in cohort subjects in 1983-1985; and 3) medical comorbidities and other important variables are contained in the dataset. The specific aims are 1) to ascertain the impact of knee OA and pain on the functional status of elders by cross-sectiona comparison to elders without OA and 2) to determine the longitudinal changes in physical function and knee pain of subjects with OA compared to those without OA. For the cross-sectional study, a secondary data analysis of data obtained at cohort examination 18 (1983-1985) will be performed. It will focus on the impact of knee OA and pain on physical function after adjusting for age, sex, marital status, living arrangements, and specific medical comorbidities, including hear disease, pulmonary disease, stroke, cancer, previous hip fracture, and diabetes. For the longitudinal study, conducted in conjunction with examination 20 (1988-1990), arthritis symptoms and physical function will be reassessed in those who had knee xrays five years earlier and are currently without senile dementia. Exam 20 non-participants will also be contacted and interviewed. Then after comprehensive data abstraction, data analysis will focus on the change in physical function from exam 18 to exam 20 as the outcome. In this analysis, exam 18 knee OA, knee symptoms (including those at exam 20) and other covariates will be tested as predictors of decline in function. This study will provide extensive documentation of the specific functional deficits associated with a very common musculoskeletal problem in the elderly. Results will delineate whether OA is a major factor affecting the decline in function experienced by many older persons. It will also yield new information concerning the link betwen medical diagnoses, symptomatology and functional performance in the elderly.

该项目的总体目标是确定膝盖的影响 老年人的身体残疾骨关节炎（OA）。 OA 长者经历的时代的患病率增加 身体机能恶化，但对 膝盖OA对老年人的功能影响。 这项研究会 在控制其他因素时检查这种影响 影响残疾，例如年龄，婚姻状况，生活安排 和医疗合并症。 Framingham心脏学习队列 将被研究。 这个小组在 解决这个问题：1）这是一个基于人群的队列 老年人（平均年龄75岁）； 2）评估膝盖OA 1983 - 1985年，在队列受试者的临床和XoRAGRAGHING上。 3）医学合并症和其他重要变量是 包含数据集中。 具体目的是1）确定膝盖OA和 横截面的长者功能状态的疼痛 与没有OA和2）的长者进行比较以确定 身体机能的纵向变化和受试者的膝盖疼痛 与没有OA的OA相比。 对于横截面 研究，对​​队列获得的数据的二级数据分析 考试18（1983-1985）将进行。 它将重点 膝盖OA和疼痛对身体机能的影响 调整年龄，性别，婚姻状况，生活安排和 特定的医学合并症，包括听到疾病，肺部 疾病，中风，癌症，以前的髋部骨折和糖尿病。 为了 纵向研究与检查结合 20（1988-1990），关节炎症状和身体功能将是 在五年前有膝盖Xrays的人重新评估，并且 目前没有老年痴呆症。 考试20非参与者将 也可以联系并采访。 然后综合 数据抽象，数据分析将集中于更改 从考试18到考试20作为结果。 在 该分析，考试18膝盖OA，膝盖症状（包括 在考试20）和其他协变量将作为预测指标 功能下降。 这项研究将提供有关特定的大量文档 与非常常见的功能缺陷 老年人的肌肉骨骼问题。 结果将描绘 OA是否是影响功能下降的主要因素 许多老年人经历。 它也会产生新的 有关链接的医学诊断链接的信息， 老年人的症状和功能性能。