Empowering Diversity in X-ray Imaging: Training, Graduate Research, and Advancements in Detector Development

增强 X 射线成像的多样性：培训、研究生研究和探测器开发的进步

基本信息

批准号：
10877539
负责人：
Shiva Abbaszadeh
金额：
$ 9.22万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA CRUZ
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-07 至 2026-05-31
项目状态：
未结题

项目摘要

ABSTRACT Cardiovascular disease (CVDs) are the leading cause of death globally. According to the American Heart Association, for early treatment of CVD and to verify if a patient should be prescribed statin therapy, calcium scoring via cardiac Computed Tomography (CT) should be performed. However, there is a limited application of calcium scoring due to limited spatial resolution of CT (~1 mm), dose concern, and out of pocket expense for patients. To address the challenges with CT calcium scoring, a new technology based on dual-layer flat panel detector is being developed under our R01 “A dual-layer flat panel X-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium” to provide opportunistic calcium score whenever X-ray is done. This technology aims to provide an opportunistic approach to X-ray imaging with a detector that improves detection and quantification of coronary artery calcium (CAC). It is based on a patent pending selenium alloy with favorable optical and electrical properties that enhance image quality. Whenever X- ray is done for any reason calcium score automatically is generated with no additional cost burden to the healthcare system. To advance the proposed technology from a functioning prototype to readiness level required for licensing to the Original Equipment Manufacturer (OEM), there are areas related to uniformity and variation across detector and yield that should be evaluated and assessed. In this diversity supplement, we will bring on a Ph.D. candidate making the transition from high energy physics to medical imaging, utilizing his expertise in detector simulation and readout systems to enable additional capability to the readout circuitry of the dual-layer detector proposed in aim 1 of the parent grant. The candidate will develop modifications to the detector architecture and flat panel readout technology for the top layer of the dual-layer detector, allowing the application of higher electric fields to achieve improved conversion efficiencies. The supplement will provide the funding required to support the student in this area, giving him mentoring and experience in the medical imaging field, while advancing the goals of the parent project to develop a dual-layer for CAC detection.

抽象的心血管疾病（CVD）是全球死亡的主要原因。根据美国的心关联，以早期治疗CVD并验证是否应开处方他汀类药物治疗，钙应通过心脏计算机断层扫描（CT）进行评分。但是，有限的应用由于CT的空间分辨率有限（〜1毫米），剂量关注和零用费用，钙评分有限患者。为了解决CT Calcium评分的挑战，这是一种基于双层平板的新技术检测器正在我们的R01下开发“基于工程的双层平板X射线检测器无定形葡萄糖核化合金，用于量化冠状动脉钙以提供机会性钙评分每当完成X射线时。该技术旨在通过一个机会提供机会主义的方法来利用改善冠状动脉钙（CAC）的检测和定量的检测器。它是基于专利持续的硒合金具有有利的光学和电气性能，可增强图像质量。每当x- 射线是由于任何原因自动生成的，而钙得分是自动生成的，而无需额外费用伯恩医疗保健系统。将提出的技术从功能的原型推向所需的准备水平对于原始设备制造商（OEM）的许可，有与统一性和变化有关的领域跨检测器和应评估和评估的产量。在这种多样性补充中，我们将获得博士学位。候选人从高能量物理学过渡进行医学成像，使用他在探测器模拟和读数系统方面的专业知识来启用其他候选人是在父授予AIM 1中提出的双层检测器的读数电路。将为检测器体系结构和平板读数技术开发修改双层检测器，允许应用较高的电场以提高转化效率。该补充剂将提供支持该领域学生的资金，使他心理和在医学成像领域的经验，同时促进了父项目的目标以开发双层用于CAC检测。