Enabling Brain Parametric Imaging of Alzheimer's disease with an Organ-dedicated PET

使用器官专用 PET 实现阿尔茨海默病的脑参数成像

基本信息

批准号：
10286644
负责人：
Shiva Abbaszadeh
金额：
$ 29.74万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA CRUZ
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10286644
关键词：
3-Dimensional Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Biological Models Blood Blood specimen Brain Brain imaging Brain scan Caliber California Carotid Arteries CdZnTe Cerebrovascular system Charge Clinical Clinical Data Common carotid artery Compton radiation Computer Simulation Consumption Crystallization Data Descending aorta Diagnosis Early Diagnosis Electronics Event Funding Geometry Head and neck structure Human Image Imaging Techniques Internal carotid artery structure Kinetics Left ventricular structure Length Location Magnetic Resonance Mathematics Measures Methods Modeling Monte Carlo Method National Institute of Biomedical Imaging and Bioengineering Neck Noise Organ Outcome Output Patients Performance Photons Physiologic pulse Positioning Attribute Positron-Emission Tomography Recovery Research Research Personnel Resolution System Techniques Technology Testing Time Tracer Universities base cost curve fitting design detector digital fluorodeoxyglucose human imaging imager imaging modality imaging system improved innovation innovative technologies insight instrumentation interest kinetic model new technology novel nuclear imaging parametric imaging prevent radiotracer simulation temporal measurement ultra high resolution

项目摘要

ABSTRACT Dynamic positron emission tomography (PET) imaging with tracer kinetic modeling has the potential to enable quantitative characterization of Alzheimer’s disease and related dementias (ADRD) but suffers from invasive blood sampling and limited spatial resolution for imaging small brain vasculature. The high volumetric resolution (~1 mm3) technology being developed under our R01 “High Spatial Resolution Dedicated Head and Neck PET System based on Cadmium Zinc Telluride” can innovatively be applied to improving ADRD imaging efforts. In this ADRD-supplement, we will augment our novel technology for brain imaging and also develop an optimization-derived input function method (ODIF) to enable our scanner to provide accurate dynamic PET imaging of ADRD and offer clinical insight into early detection of ADRD and the quantification of radiotracer concentrations; resulting in imaging that is less invasive and more accurate. Thus far, our scanner from the R01, has demonstrated a depth of interaction <1 mm, high multiple interaction photon event recovery (accuracy >86%), and fully-functional low-noise in-house readout electronics (trigger on energies above 15 keV with electronic noise of 1% FWHM measured by test pulse injecting charge equivalent of 511 keV). These features minimize the spillover and partial volume effects and improve the carotid-derived input function for brain kinetic quantification. The ODIF method will have the potential to further improve the performance of our dedicated system and it can be applied to many existing brain-dedicated scanners and clinical scanners for ADRD imaging. Therefore, our ultra-high resolution and modular design with high packing fraction (~99%) is excellently positioned to improve ADRD imaging as we will add a neck imager to brain-dedicated systems and have high- quality imaging output.

抽象的具有示踪动力学模型的动态正电子发射断层扫描 (PET) 成像有可能使阿尔茨海默氏病和相关痴呆症 (ADRD) 的定量表征，但遭受侵袭性血液采样和有限的空间分辨率对小脑血管进行成像高体积分辨率。 (~1 mm3) 技术正在我们的 R01“高空间分辨率专用头颈 PET”下开发基于碲化镉锌的系统”可以创新地应用于改善 ADRD 成像工作。在这个 ADRD 补充中，我们将增强我们的脑成像新技术，并开发一种优化衍生输入函数法 (ODIF) 使我们的扫描仪能够提供准确的动态 PET ADRD 成像，并为 ADRD 早期检测和放射性示踪剂定量提供临床见解迄今为止，我们的 R01 扫描仪可实现侵入性更小、更准确的成像。已证明相互作用深度<1毫米，高多重相互作用光子事件恢复（精度 >86%），以及功能齐全的低噪声内部读出电子设备（在能量高于 15 keV 时触发通过测试脉冲注入电荷当量 511 keV 测得 1% FWHM 的电子噪声。最大限度地减少溢出和部分容量效应，并改善脑动力学的颈动脉源性输入功能 ODIF 方法将有可能进一步提高我们专用的性能。系统，它可以应用于许多现有的大脑专用扫描仪和 ADRD 成像临床扫描仪。因此，我们的超高分辨率和高填充率（~99%）的模块化设计非常出色旨在改善 ADRD 成像，因为我们将在大脑专用系统中添加颈部成像仪，并具有高高质量的成像输出。