High spatial resolution dedicated head and neck PET system based on cadmium zinc telluride detectors

基于碲化镉锌探测器的高空间分辨率专用头颈 PET 系统

• 批准号: 9789282
• 负责人: Shiva Abbaszadeh
• 金额: $ 64.1万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789282
• 关键词: 3-Dimensional; Address; Aftercare; Algorithms; Animals; Anodes; Area; Beds; Calibration; Cathodes; CdZnTe; Charge; Clinic; Clinical Research; Collection; Crystallization; Detection; Development; Diagnosis; Diagnostic; Disease; Elements; Emission-Computed Tomography; Engineering; Evaluation; Event; Exhibits; Floor; Foundations; Functional Imaging; Goals; Head and Neck Cancer; Head and neck structure; Hospitals; Hot Spot; Illinois; Image; Invaded; Knowledge; Larynx; Lead; Malignant Neoplasms; Methods; Mucous Membrane; Neck; Noise; Nuclear; Patient-Focused Outcomes; Patients; Performance; Photons; Physicians; Plasma; Positioning Attribute; Positron-Emission Tomography; Probability; Procedures; Property; Protocols documentation; Public Health; Radiation; Radiology Specialty; Recovery; Recurrence; Research; Research Personnel; Research Project Grants; Resectable; Resolution; Scanning; Scheme; Semiconductors; Staging; Surface; System; Technology; Thinness; Thyroid cartilage structure; Time; Tissues; Translating; United States; Universities; Validation; X-Ray Computed Tomography; advanced system; base; cancer diagnosis; cancer imaging; cancer recurrence; cancer therapy; chemotherapy; data acquisition; design; detector; electric field; experience; image reconstruction; imaging approach; imaging platform; imaging system; improved; in vivo; individualized medicine; industry partner; kinematics; lymph nodes; millimeter; mortality; novel; outcome forecast; photon-counting detector; prototype; success; treatment planning; tumor; tumor growth; voltage

PROJECT SUMMARY Current head and neck cancer diagnosis and treatment planning suffers from poor spatial resolution of whole-body positron emission tomography (WB-PET) scans. In the neck, where tissue layers are thin, the spatial resolution of WB-PET (4-6 mm) is not sufficient to evaluate small lymph nodes (<5 mm), establish how far the tumor has invaded locally, and guide the decision to resect a tumor rather than irradiate and deliver chemotherapy. This proposal, responsive to PAR-18-009, “Academic-Industrial Partnerships to Translate and Validate in vivo Cancer Imaging Systems,” seeks to address this problem by translating high resolution radiation detection technology to head and neck imaging. The project research team consists of researchers from the Department of Nuclear, Plasma, and Radiological Engineering at the University of Illinois at Urbana-Champaign and eV Products Inc., a world leader in semiconductors for radiation detection. To achieve its goal, this research will pursue the design, development, optimization, characterization, and validation of a dedicated head and neck PET scanner. The proposed system will be the first head and neck scanner to exhibit features as small as 1 mm with high photon sensitivity, enabled by the use of high energy and spatial resolution properties of cadmium zinc telluride (CZT) crystals. This system will be integrated into a transportable stage and is designed to not interfere with the conventional workflow of the WB- PET scan procedure, and has the additional attraction of being used for dynamic PET studies. We expect that this dedicated head and neck PET imaging system will deliver the following new capabilities: i) detection and evaluation of small lymph nodes, ii) improved treatment planning and determining the extent of the tumor growth, and iii) improved confidence in differentiating post-treatment change from tumor recurrence. The system will consist of two panels and have an adjustment for panel-to-panel separation distance. Each panel contains 150, 4x4x0.5 cm3 cross-strip CZT crystals covering a 20x15 cm2 panel area. The crystals will be mounted in an edge-on configuration for increased photon detection efficiency. A novel event recovery scheme based on the 3D position sensitive cross-strip crystals will be developed to recover multiple interaction photon events, reject random events, and significantly increase the photon sensitivity of the system. In the final year of the project, a study consisting of 20 patients will be conducted to evaluate the performance of the developed prototype and validate the potential benefits.

项目摘要 当前的头颈癌诊断和治疗计划遭受空间不良 全身正电子发射断层扫描（WB-PET）扫描的分辨率。在脖子上 组织层很薄，WB-PET的空间分辨率（4-6毫米）不足以评估 小淋巴结（<5 mm），确定肿瘤在局部侵入多远，并引导 决定切除肿瘤而不是辐照并提供化学疗法。这个建议， 响应Par-18-009，“学术工业合作伙伴关系，以翻译和验证体内 癌症成像系统，“试图通过翻译高分辨率辐射来解决此问题 检测到头部和颈部成像的技术。项目研究团队包括 核，血浆和放射学工程系的研究人员 伊利诺伊大学Urbana-Champaign和EV Products Inc. 辐射检测的半导体。为了实现其目标，这项研究将追求设计， 专门的头和颈宠物的开发，优化，表征和验证 扫描器。拟议的系统将是第一个裸露功能的头部和颈部扫描仪 高达1毫米，具有高光子灵敏度，可以使用高能量和空间 牙加啉锌锌（CZT）晶体的分辨率。该系统将集成到 一个透明的阶段，旨在不干扰WB-的常规工作流程 PET扫描程序，并具有用于动态PET研究的其他吸引力。 我们希望这种专门的头和颈宠物成像系统将提供以下新的 功能：i）检测和评估小淋巴结，ii）改进的治疗计划 并确定肿瘤生长的程度，ii）提高了区分的信心 肿瘤复发后治疗后的变化。该系统将由两个面板组成，并具有 面板与面板分离距离的调整。每个面板包含150、4x4x0.5 cm3 覆盖20x15 cm2面板区域的跨扫描CZT晶体。晶体将安装在 用于提高光子检测效率的边缘配置。一种新颖的事件恢复计划 基于3D位置，将开发敏感的跨条纹晶体以恢复多个 相互作用的光子事件，拒绝随机事件，并显着提高光子灵敏度 系统。在项目的最后一年，将进行20例患者的研究 评估开发原型的性能并验证潜在的好处。