Improved Biocompatibility and Biodegradation of Zn-based Stent Materials through Surface Nano-Engineering

通过表面纳米工程改善锌基支架材料的生物相容性和生物降解性

• 批准号: 9035393
• 负责人: Jaroslaw W Drelich
• 金额: $ 18.21万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9035393
• 关键词: Alloys; American Heart Association; Arteries; Behavior; Biocompatible; Biodegradation; Blood Vessels; Characteristics; Chronic; Corrosion; Engineering; Environment; Evaluation; Exhibits; Failure; Film; Geometry; Health; Implant; Lead; Lithium; Magic; Metals; Methods; Michigan; Modification; Oxides; Penetration; Physiological; Property; Rare Earth Metals; Rattus; Research; Risk; Sampling; Stents; Structure; Surface; Tensile Strength; Testing; Thick; Time; Zinc; base; biomaterial compatibility; design; implant material; implantation; improved; in vivo; meetings; nanoengineering; percutaneous coronary intervention; programs; statistics; success

 DESCRIPTION: Metal stents are commonly used to revascularize occluded arteries. The American Heart Association states that 622,000 percutaneous coronary interventions were performed in 2007 (the most recent period for which statistics have been compiled). A bio absorbable metal stent that harmlessly erodes away over time could minimize the normal chronic risks associated with permanent stents. Mg- and Fe-based alloys are currently pursued in designing such biodegradable stents with a limited success. Only one commercial Mg-based stent called Lekton Magic Stent and developed by Biotronik was recently introduced but it dissolves away too fast and involves rare earth elements, which have unknown biocompatibility. The research proposed at Michigan Tech aims to develop, for the first time, an alternative line of Zn-based stents that last 6-9 months in vivo and contain biocompatible Li. Preliminary study suggests that zinc exhibits ideal physiological corrosion behavior for bio absorbable stent application. The viability of a zinc stent was demonstrated in our preliminary study. The corrosion behavior in vivo for zinc and zinc-lithium with a passive layer of oxide film and its effect on the degradation rate in the vascular environment remain open questions, and are the subjects of the proposed program. The overall feasibility of a bio absorbable zinc and zinc-based stents with engineered surfaces will be evaluated. An in vivo evaluation of materials bio corrosion will be completed utilizing a recently developed arterial implantation method in which a sample with wire geometry is implanted into the arterial wall of a rat. Zinc-lithium alloys will be prepared in order to tailor the material properties to accepted values of tensile strength, elongation to failure, and penetration rate. Oxide films of varying thickness and structure will be formulated on surfaces of both zinc and zinc-lithium alloys using an anodization. The surface engineering of thin oxide films will lead to tunable rates of bio corrosion. The research will lead to selection of surface modification characteristics that meets the following criteria: i) improve hemocompatibility and biocompatibility and zinc-based implant materials; ii) keep corrosion rates below the 0.02 mm/year value in the first 3-4 months; and iii) will not protect metal from accelerated (>0.02 mm/year) biodegradation after 4 months.

 描述：金属支架通常用于血运重建动脉。美国心脏协会指出，2007年进行了622,000次经皮冠状动脉干预措施（最近已汇总了统计数据的最新时期）。随着时间的流逝，无害发射的生物吸收金属支架可以最大程度地减少与永久支架相关的正常慢性风险。目前，在设计此类可生物降解支架方面，基于MG和FE的合金的成功有限。最近引入了一个基于MG的商业基于MG的支架，并由Biotronik开发，但它溶解得太快，涉及稀土元素，这些元素具有未知的生物相容性。密歇根理工学院提出的研究旨在首次开发基于Zn的支架的另一种基础线，该系列持续6-9个月在体内并含有生物相容性的LI。初步研究表明，锌为生物可吸收支架应用表现出理想的生理腐蚀行为。我们的初步研究证明了锌支架的生存能力。带有氧化物膜的被动层的锌和锌的体内腐蚀行为及其对血管环境中降解速率的影响仍然是悬而未决的问题，并且是拟议程序的主题。将评估具有生物吸收锌和基于锌的支架具有工程表面的总体可行性。材料生物腐蚀的体内评估将使用最近开发的伪影方法完成，其中将带有电线几何形状的样品植入了大鼠的伪影壁中。锌 - 锂合金将是 为了将材料特性定制为应接受的拉伸强度，伸长到失败和穿透速率的值。厚度和结构的氧化膜将是 使用阳极化在锌和锌合金的表面上配制。薄氧化物膜的表面工程将导致可调的生物腐蚀速率。这项研究将领导 选择符合以下标准的表面修饰特征的选择：i）提高血液相容性和生物相容性以及基于锌的植入物材料； ii）在最初的3-4个月内保持低于0.02毫米/年的腐蚀速率；和iii）不会在4个月后保护金属免受加速（> 0.02 mm/年）的生物降解。

项目成果

Zinc-based alloys for degradable vascular stent applications.

• DOI: 10.1016/j.actbio.2018.03.005
• 发表时间: 2018-04-15
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Mostaed E;Sikora-Jasinska M;Drelich JW;Vedani M
• 通讯作者: Vedani M

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate.

• DOI: 10.1016/j.actbio.2017.05.045
• 发表时间: 2017-08
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Drelich AJ;Zhao S;Guillory RJ 2nd;Drelich JW;Goldman J
• 通讯作者: Goldman J

Targeted Delivery of Sucrose-Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long-Distance Translocation.

• DOI: 10.1002/smll.202304588
• 发表时间: 2023-10
• 期刊: Small
• 影响因子: 13.3
• 作者: Su-Ji Jeon;Yilin Zhang;Chris Castillo;Valeria Nava;Kurt Ristroph;Benjamin Therrien;Leticia Meza;Gregory V Lowry;J. P. Giraldo

Metallic zinc exhibits optimal biocompatibility for bioabsorbable endovascular stents.

• DOI: 10.1016/j.msec.2015.07.022
• 发表时间: 2015-11-01
• 期刊: Materials science & engineering. C, Materials for biological applications
• 作者: Bowen PK;Guillory RJ 2nd;Shearier ER;Seitz JM;Drelich J;Bocks M;Zhao F;Goldman J
• 通讯作者: Goldman J

Novel high-strength, low-alloys Zn-Mg (<0.1wt% Mg) and their arterial biodegradation.

• DOI: 10.1016/j.msec.2017.11.021
• 发表时间: 2018-03-01
• 期刊: Materials science & engineering. C, Materials for biological applications
• 作者: Jin H;Zhao S;Guillory R;Bowen PK;Yin Z;Griebel A;Schaffer J;Earley EJ;Goldman J;Drelich JW
• 通讯作者: Drelich JW