Corrosion Fatigue Resistant and Intimal Hyperplasia Suppressive Biometal for Bioabsorbable Stents

用于生物可吸收支架的抗腐蚀疲劳和内膜增生抑制生物金属

• 批准号: 9816239
• 负责人: Jaroslaw W Drelich
• 金额: $ 36.97万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816239
• 关键词: Abdomen; Absorbable Implants; Address; Age; Alloys; Anti-inflammatory; Aorta; Arteries; Behavior; Benchmarking; Biodegradation; Blood Vessels; Cells; Characteristics; Chronic; Complex; Coronary; Corrosion; Defect; Developed Countries; Developing Countries; Diet; Drops; Elements; Endothelium; Engineering; Ensure; Environment; Exhibits; Failure; Fatigue; Formulation; Fracture; Grain; Health; Heart Diseases; Human; Hyperplasia; Individual; Industrialization; Inflammatory; Inflammatory Response; Iron; Laboratories; Location; Magnesium; Mechanics; Metabolic Clearance Rate; Metals; Modeling; Obesity; Oxides; Patients; Performance; Periodicity; Phase; Physiological; Pilot Projects; Plasma; Precipitation; Procedures; Property; Rattus; Research; Resistance; Risk; Solubility; Stainless Steel; Stents; Stress; System; Temperature; Testing; Texture; Thick; Time; Toxic effect; Trace Elements; Work; Zinc; base; biomaterial compatibility; cardiovascular health; density; design; ductile; experience; falls; improved; in vivo; interest; mechanical load; mechanical properties; metallicity; novel; particle; prototype; response; scaffold; side effect

Summary Heart disease is of great societal interest due to its drastic impact on health in industrialized nations, especially in developed countries where obesity rates are high and the typical diet is not conducive to cardiovascular health. While invasive procedures are not desirable, they are often crucial to ensuring patient survival. The five million coronary stents administered world- wide each year remain present in the human artery for the lifetime of the patient. This has resulted in the emergence of several serious side effects. A bioabsorbable metal stent that harmlessly erodes away over time could minimize the normal chronic risks associated with permanent stents. Our laboratory has been working to refine the composition and microstructure of biodegradable Zn-based binary alloys and test their behavior in the vascular environment over the last four years in an effort to develop a metal with mechanical properties and biocompatibility required for endovascular stent applications. Having contributed enormously to the scientific understanding of Zn-based systems, we are now ready to develop more complex Zn-based alloys with 2-3 alloying elements that meet benchmark values for biodegradable stents, including: 1) have superior corrosion fatigue resistance that eliminates early stage (6 to 9 months) fracturing of biodegradable stents (common problem in Mg-based and Zn-based stents prototyped in the last several years); 2) maintain in vivo corrosion rates close to the 0.02 mm/year value; 3) exhibit >200 MPa yield strength, and >25-30% elongation to failure; and 4) demonstrate biocompatibility in terms of short- and long-term inflammatory responses, re-endothelialization, and suppressed intimal hyperplasia, similar or better than 316L stainless steel (industrial standard for stent materials).

概括 心脏病具有极大的社会兴趣，因为它对工业化的健康影响很大 国家，尤其是在肥胖率很高且典型饮食的发达国家 不利于心血管健康。虽然侵入性程序是不可取的，但它们是 通常对于确保患者生存至关重要。五百万冠状动脉支架管理了世界 - 在患者的一生中，每年都存在于人类动脉中。这就是 导致出现了几种严重的副作用。可生物吸附的金属支架 随着时间的流逝，无害的侵蚀可能会最大程度地减少与之相关的正常慢性风险 永久支架。 我们的实验室一直在努力完善可生物降解的组成和微观结构 基于Zn的二进制合金并在过去四个血管环境中测试其行为 多年以开发具有机械性能和生物相容性的金属 血管内支架应用。为科学理解做出了巨大贡献 在基于Zn的系统中，我们现在准备以2-3的形式开发更复杂的基于Zn的合金 符合可生物降解支架基准值的合金元素，包括：1） 抗腐蚀疲劳耐药性，消除了早期阶段（6至9个月） 可生物降解的支架（基于Mg的基于MG和Zn的支架的常见问题 几年）; 2）保持体内腐蚀速率接近0.02 mm/年的值； 3）展览 > 200 MPa产量强度，> 25-30％的伸长率伸长到失败； 4）演示 在短期和长期炎症反应，重新内皮化方面的生物相容性， 并抑制内膜增生，比316L不锈钢（工业）相似或更好 支架材料的标准）。