Transplant Surgery Scientist Training Program

移植外科科学家培训计划

• 批准号: 10628809
• 负责人: Richard M Green
• 金额: $ 24.53万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628809
• 关键词: Scientist; Training Programs; Transplantation Surgery

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course for millions of Americans afflicted with end- stage liver disease. However, several issues limit broader access to liver transplantation and better outcomes including an incomplete understanding of liver disease pathogenesis, the need for better therapies and assessment of clinical outcomes, improved donor availability and access to medical care. Therefore, the long- term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support multi- disciplinary, inter-departmental liver transplant-related research that will improve outcomes for patients with end- stage liver diseases. We will leverage scientific advances in the life sciences across many academic disciplines, with a goal of improving the health of pre- and post-transplantation liver patients, consistent with the mission of NIDDK. The TSSTP will train the next generation of surgeons, hepatologists and PhD investigators in a broad range of liver transplantation-related fields. The goals of the program are to educate trainees about the nature of existing barriers that hinder improved access, lower complications, and improve outcomes in liver transplantation; and to train TSSTP trainees with a deep knowledge of state-of-the art tools, methodologies, and scientific approaches that may be used to overcome these barriers. We will apply a team science approach that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX) model which promotes the concept of inter-dependent, multi-disciplinary research. The MATRIX training model builds on the interdisciplinary team science structure within the Comprehensive Transplant Center (CTC) and offers 1) a basic and translational scientific research track within the Northwestern University Collaborative for Transplant Research in Immuno/Hepatobiology and Biomedical Engineering (NUCTRIBE), and 2) outcomes science track within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC). Trainees will benefit from a customized MATRIX that will incorporate multi-disciplinary mentoring from both NUCTRIBE and NUTORC (3-5 TSSTP mentors). Each project must have a link to liver transplantation or hepatology, and enhancing our long-term goal of improving patient care. In order to successfully reach these goals, we seek to: 1) provide inter-disciplinary training and mentorship that brings together clinicians and scientists with state-of- the-art research methodologists; 2) sustain an administrative structure that enhances quality and diversity of the candidate pool and trainees; 3) conduct rigorous and responsible research; 4) optimize mentor and trainee feedback with an ongoing evaluation process to enhance the ability of the program to meet its goals and objectives; and 5) provide training opportunities, including many lectures and seminars, that span NUCTRIBE and NUTORC at their intersection with clinical liver transplantation. This comprehensive, multi-disciplinary approach will allow us to enhance our liver transplantation-related research and train the next generation on physicians and scientists so that we can improve patient care.

项目摘要/摘要 移植有望扭转数百万遭受最终困扰的美国人的临床课程 肝病阶段。但是，几个问题限制了更广泛的肝脏移植和更好的结果 包括对肝病发病机理的不完全了解，需要更好的疗法和 评估临床结果，改善捐助者的可用性和获得医疗服务。因此，长期 移植手术科学家培训计划（TSSTP）的任期目标是促进和支持多 纪律间部门间肝移植相关的研究将改善终终患者的预后 肝脏疾病。我们将利用许多学科的生命科学的科学进步， 目的是改善移植前和移植后肝脏患者的健康状况，与 niddk。 TSSTP将在广泛的 肝移植相关场的范围。该计划的目标是教育学员有关性质 现有的障碍，阻碍了进度，降低并发症和改善肝脏的结果 移植；并以深入了解最先进的工具，方法和 可以用来克服这些障碍的科学方法。我们将采用团队科学方法 利用跨学科专家（MATRIX）模型的模块化方法进行移植研究，该模型 促进相互依存的多学科研究的概念。矩阵训练模型建立在 综合移植中心（CTC）内的跨学科团队科学结构，并提供1）基本 以及西北大学移植合作的转化科学研究轨道 免疫/肝生物学和生物医学工程（Nuctribe）和2）成果科学轨迹的研究 在西北大学的移植成果研究合作组织（Nutorc）中。学员会 从定制的矩阵中受益，该基质将结合核心和核心的多学科指导 Nutorc（3-5 TSSTP导师）。每个项目都必须与肝移植或肝病学链接，并且 增强我们改善患者护理的长期目标。为了成功实现这些目标，我们寻求： 1）提供跨学科的培训和指导，将临床医生和科学家汇集在一起 艺术研究学家； 2）维持一种行政结构，可提高质量和多样性 候选泳池和学员； 3）进行严格和负责任的研究； 4）优化导师和学员 反馈和持续的评估过程，以增强计划实现其目标的能力和 目标； 5）提供培训机会，包括许多讲座和研讨会 和在其与临床肝移植​​的交点上的营养。这个全面的多学科 方法将使我们能够增强与肝脏移植相关的研究并训练下一代 医师和科学家，以便我们可以改善患者护理。

项目成果

What patients think doctors know: beliefs about provider knowledge as barriers to safe medication use.

患者认为医生知道什么：对提供者知识的信念是安全用药的障碍。

• DOI: 10.1016/j.pec.2013.06.030
• 发表时间: 2013
• 期刊: Patient education and counseling
• 影响因子: 3.5
• 作者: Serper,Marina;McCarthy,DanielleM;Patzer,RachelE;King,JenniferP;Bailey,StacyC;Smith,SamuelG;Parker,RuthM;Davis,TerryC;Ladner,DanielaP;Wolf,MichaelS
• 通讯作者: Wolf,MichaelS

Editorial: sarcopenia in liver transplantation-our weakest patients may need the strongest push.

社论：肝移植中的肌少症——我们最虚弱的患者可能需要最强的推动。

• DOI: 10.1111/apt.15204
• 发表时间: 2019
• 期刊: Alimentary pharmacology & therapeutics
• 影响因子: 7.6
• 作者: Mazumder,Nikhilesh;Rinella,Mary
• 通讯作者: Rinella,Mary

A novel strategy for cardiopulmonary support during lung transplantation.

肺移植期间心肺支持的新策略。

• DOI: 10.21037/jtd.2017.12.111
• 发表时间: 2018
• 期刊: Journal of thoracic disease
• 影响因子: 2.5
• 作者: Fernandez,Ramiro;DeCamp,MalcolmM;Bharat,Ankit
• 通讯作者: Bharat,Ankit

The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story.

• DOI: 10.1016/j.surg.2009.06.052
• 发表时间: 2009-10
• 期刊: Surgery
• 影响因子: 3.8
• 作者: Skaro AI;Jay CL;Baker TB;Wang E;Pasricha S;Lyuksemburg V;Martin JA;Feinglass JM;Preczewski LB;Abecassis MM
• 通讯作者: Abecassis MM

Role of monocytes and macrophages in regulating immune response following lung transplantation.

• DOI: 10.1097/mot.0000000000000313
• 发表时间: 2016-06
• 期刊: Current opinion in organ transplantation
• 影响因子: 2.2
• 作者: Chiu S;Bharat A
• 通讯作者: Bharat A