Transplant Surgery Scientist Training Program

移植外科科学家培训计划

• 批准号: 10188847
• 负责人: Richard M Green
• 金额: $ 3.19万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188847
• 关键词: Scientist; Training Programs; Transplantation Surgery

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases. However, a number of issues limit broader access to transplantation and various complications related to the need for lifetime immunosuppression affect the long-term success of transplantation. Thus, the long-term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support inter-dependent transplant research in order improve outcomes for patients in need of transplantation. We will leverage scientific advances in the life sciences across academic disciplines, and focus these on advancing transplantation, directly and indirectly improving the health of patients in need of GI organs, consistent with the mission of NIDDK. We will train the next generation of postdoctoral scientists (PhDs) and clinician scientists (MDs) in surgery and GI medicine who will advance the field of transplantation, preferably as team scientists. The specific aims of the TSSTP are 1) to educate trainees about the nature of existing barriers both to higher access to, and lower complications from transplantation, and 2) to arm them with a deep knowledge of state-of- the art tools, methodologies, and scientific approaches that can potentially be used to overcome these barriers. Significant `cross-talk' exists in clinical transplantation, thus, we will apply a training program that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX), a model that espouses the concept of inter-dependent team science and research between disciplines. This training model will be deployed across 2 separate training tracks that include 1) basic and translational scientific research within the Northwestern University Collaborative for Transplant Research in Immunobiology and Biomedical Engineering (NUCTRIBE), and 2) health sciences and outcomes research within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC), and implement these in our second funding cycle. A total of 3 trainees will benefit for 2 years each from a customized MATRIX that will incorporate multidisciplinary co- mentoring. Each project must have a direct link to transplantation surgery, and the anchoring discipline in each MATRIX is a transplant clinician. The tactical objectives of this T32 are to: 1) provide stipend support for trainees; 2) provide multi-level, inter-disciplinary mentorship bringing together transplant clinician-scientists and non-clinician-scientists with state-of-the research methodologists; 3) protect trainees from clinical activities that compete for their time; 4) sustain an administrative structure that enhances both the quality and diversity of the candidate pool and trainees; 5) provide training opportunities that span the spectrum from both basic/translational science (NUCTRIBE) to clinical/health services and outcomes research (NUTORC) at their intersection with clinical transplantation; and 6) continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives.

项目概要/摘要 移植有望扭转数百万患有终末期心脏病的美国人的临床病程。 阶段器官衰竭，包括许多胃肠道（GI）疾病。但诸多问题限制了 更广泛的移植机会和与终生需求相关的各种并发症 免疫抑制影响移植的长期成功。因此，该组织的长期目标是 移植外科科学家培训计划（TSSTP）旨在促进和支持相互依赖的移植 研究以改善需要移植的患者的结果。我们将利用科学 生命科学跨学科的进步，并将重点放在推进移植上， 直接和间接改善需要胃肠道器官的患者的健康，这与我们的使命是一致的 尼德克。我们将培养下一代博士后科学家（PhD）和临床科学家（MD） 外科和胃肠道医学将推动移植领域的发展，最好是作为团队科学家。这 TSSTP 的具体目标是 1) 教育学员了解现有障碍的性质 获得移植并降低并发症，2）让他们深入了解移植现状 可以用来克服这些障碍的艺术工具、方法论和科学方法。 临床移植中存在显着的“串扰”，因此，我们将应用一个利用 跨学科专家进行移植研究的模块化方法 (MATRIX)，一种支持 学科之间相互依赖的团队科学和研究的概念。该训练模型将 部署在 2 个独立的培训轨道上，其中包括 1) 领域内的基础和转化科学研究 西北大学免疫生物学和生物医学工程移植研究合作组织 (NUCTRIBE)，以及 2) 西北大学移植内的健康科学和成果研究 结果研究合作组织（NUTORC），并在我们的第二个资助周期中实施这些。共 3 个 受训者将受益于每人两年的定制矩阵，该矩阵将包含多学科合作 指导。每个项目必须与移植手术有直接联系，并且每个项目的锚定学科 MATRIX 是一名移植临床医生。该 T32 的战术目标是： 1) 提供津贴支持 实习生； 2) 提供多层次、跨学科的指导，将移植临床医生-科学家聚集在一起， 拥有最先进研究方法学家的非临床科学家； 3) 保护学员免受以下临床活动的影响 争夺时间； 4）维持一个能够提高质量和多样性的行政结构 候选人库和实习生； 5）提供跨领域的培训机会 基础/转化科学 (NUCTRIBE) 到临床/卫生服务和结果研究 (NUTORC) 与临床移植的交叉； 6) 继续进行持续的评估过程以确定 该计划是否实现其目的和目标。