Transplant Surgery Scientist Training Program

移植外科科学家培训计划

• 批准号: 9922898
• 负责人: Richard M Green
• 金额: $ 26.8万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9922898
• 关键词: Scientist; Training Programs; Transplantation Surgery

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases. However, a number of issues limit broader access to transplantation and various complications related to the need for lifetime immunosuppression affect the long-term success of transplantation. Thus, the long-term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support inter-dependent transplant research in order improve outcomes for patients in need of transplantation. We will leverage scientific advances in the life sciences across academic disciplines, and focus these on advancing transplantation, directly and indirectly improving the health of patients in need of GI organs, consistent with the mission of NIDDK. We will train the next generation of postdoctoral scientists (PhDs) and clinician scientists (MDs) in surgery and GI medicine who will advance the field of transplantation, preferably as team scientists. The specific aims of the TSSTP are 1) to educate trainees about the nature of existing barriers both to higher access to, and lower complications from transplantation, and 2) to arm them with a deep knowledge of state-of- the art tools, methodologies, and scientific approaches that can potentially be used to overcome these barriers. Significant `cross-talk' exists in clinical transplantation, thus, we will apply a training program that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX), a model that espouses the concept of inter-dependent team science and research between disciplines. This training model will be deployed across 2 separate training tracks that include 1) basic and translational scientific research within the Northwestern University Collaborative for Transplant Research in Immunobiology and Biomedical Engineering (NUCTRIBE), and 2) health sciences and outcomes research within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC), and implement these in our second funding cycle. A total of 3 trainees will benefit for 2 years each from a customized MATRIX that will incorporate multidisciplinary co- mentoring. Each project must have a direct link to transplantation surgery, and the anchoring discipline in each MATRIX is a transplant clinician. The tactical objectives of this T32 are to: 1) provide stipend support for trainees; 2) provide multi-level, inter-disciplinary mentorship bringing together transplant clinician-scientists and non-clinician-scientists with state-of-the research methodologists; 3) protect trainees from clinical activities that compete for their time; 4) sustain an administrative structure that enhances both the quality and diversity of the candidate pool and trainees; 5) provide training opportunities that span the spectrum from both basic/translational science (NUCTRIBE) to clinical/health services and outcomes research (NUTORC) at their intersection with clinical transplantation; and 6) continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives.

项目摘要/摘要 移植有望扭转数百万美国人的临床过程 阶段器官衰竭，包括许多胃肠道（GI）疾病。但是，许多问题限制 更广泛地获得移植和与终生需求相关的各种并发症 免疫抑制会影响移植的长期成功。因此，长期目标 移植手术科学家培训计划（TSSTP）是促进和支持相互依赖的移植 研究需要改善需要移植的患者的预后。我们将利用科学 跨学科的生命科学进步，并将这些专注于推进移植， 直接和间接地改善需要胃肠道器官的患者的健康状况，与 niddk。我们将培训下一代博士后科学家（PHD）和临床医学家（MDS） 手术和胃肠道医学，他们将推进移植领域，最好是团队科学家。这 TSSTP的具体目标是1）教育受训者有关现有障碍的性质，既提高 从移植中获得和降低并发症，以及2）以深入了解 可以用来克服这些障碍的艺术工具，方法和科学方法。 临床移植中存在着重要的“串扰”，因此，我们将采用一个利用该计划 跨学科专家（MATRIX）的移植研究模块化方法，该模型拥护该模型 相互依赖的团队科学和学科研究的概念。该培训模型将是 部署在两个单独的培训轨道上，其中包括1）基础和转化科学研究 西北大学免疫生物学和生物医学工程的移植研究合作 （Nuctribe）和2）西北大学移植中的健康科学和结果研究 结果研究合作（NutORC），并在我们的第二个融资周期中实施。总共3个 受训人员将从定制的矩阵中每个受益2年，该矩阵将结合多学科共同 指导。每个项目必须直接与移植手术和锚定学科有直接联系 矩阵是移植临床医生。该T32的战术目标是：1）为 学员； 2）提供多层次的，跨学科的指导，将移植临床医生与科学家和 具有最先进的方法学家的非律师科学家； 3）保护受训者免受临床活动的侵害 争夺他们的时间； 4）维持一种行政结构，可提高质量和多样性 候选泳池和学员； 5）提供跨越两者范围的培训机会 基础/转化科学（Nuctribe）临床/卫生服务和结果研究（NutORC） 与临床移植的交集； 6）继续进行确定的持续评估过程 该计划是否实现其目标。