Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

范德比尔特癌症分子和遗传流行病学培训计划

• 批准号: 10628358
• 负责人: XIAO-Ou SHU
• 金额: $ 39.65万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628358
• 关键词: Molecular Epidemiology; Training Programs; cancer epidemiology; genetic epidemiology

PROJECT SUMMARY The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. The field of cancer epidemiology is moving rapidly toward a new era in which interdisciplinary and multidisciplinary collaborative research is the central theme. This necessitates a growth of workforce of scientists working at the interfaces of epidemiology, molecular biology, and genetics. The Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt-MAGEC), launched in 2012 with NCI R25 funding and currently supported by a T32 grant, is designed to fill the gap with a goal of providing postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey-research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer. The specific aims of the Vanderbilt MAGEC program are: 1) To recruit ethnically-diverse candidates with strong backgrounds in epidemiology, genetics, and/or biology. 2) To deliver individualized didactic training tailored to complement each trainee’s prior training background and launch them into their desired career paths (molecular or genetic epidemiology of cancer). This training consists of courses, seminars, studios, journal clubs, conferences and research grant preparation. 3) To establish a multi-disciplinary mentor team for each trainee and integrate trainees into NCI-funded cancer epidemiology research projects. 4) To evaluate the impact of the Vanderbilt MAGEC program by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing high-quality papers in peer-reviewed journals and submitting a grant proposal to an internal or external funding agency based on the NIH format. Long-term outcomes include cancer research career placements and NIH grant funding. The MAGEC program, built upon an outstanding research and education training environment; a pool of 31 excellent, well-funded researchers and educators; 100 ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and a rich history of interdisciplinary training, has met remarkable success during the current grant cycle. During the last 4 years and 9 months, 12 fellows received or are currently receiving MAGEC training; of these, 2 graduated trainees obtained faculty positions, and both received K12 fellowship awards, and one received two additional career development awards. Another five graduated fellows are working in research-intensive settings. Trainees contributed to 56 publications, 30 as first author. The program is mature and is in an excellent position to continue growing. The renewal program will support 6 postdoctoral fellows. The expected training duration for the MAGEC program is 3 years. Continued support of the program is essential for sustaining its success and extending its impact on training a new generation of elite molecular and genetic cancer epidemiologists and leaders in the new era of precision medicine and prevention.

项目概要 分子生物学和遗传学技术和知识的快速发展和进步 导致了癌症病因学研究的重大突破 癌症流行病学领域正在不断发展。 迅速迈向以跨学科、多学科协作研究为中心的新时代 这需要增加从事流行病学研究的科学家队伍， 分子生物学和遗传学范德比尔特分子和遗传流行病学培训计划。 Cancer (Vanderbilt-MAGEC) 于 2012 年在 NCI R25 资助下启动，目前由 T32 拨款支持， 旨在填补这一空白，目标是为来自不同学科的博士后研究员提供 方法论工具、实用的实验室和调查研究知识以及实践研究和资助 在分子和遗传流行病学领域开展独立职业所需的写作经验 范德比尔特 MAGEC 计划的具体目标是： 1) 招募不同种族的候选人。 具有深厚的流行病学、遗传学和/或生物学背景 2) 提供个性化的教学培训。 量身定制，以补充每位学员之前的培训背景，并帮助他们进入自己想要的职业生涯 路径（癌症的分子或遗传流行病学）该培训包括课程、研讨会、工作室、 期刊俱乐部、会议和研究资助准备 3) 建立多学科导师团队。 每位学员并将学员纳入 NCI 资助的癌症流行病学研究项目 4) 评估 通过跟踪短期和长期预期结果来了解范德比尔特 MAGEC 计划的影响。 所有学员的成果包括在同行评审期刊上发表高质量论文并提交 根据 NIH 格式向内部或外部资助机构提出的资助提案包括。 癌症研究职业安置和 NIH 拨款资助。 研究和教育培训环境；拥有31名优秀、资金充足的研究人员和教育工作者； 100 个正在进行的前沿研究项目；特殊数据/生物样本和人口资源； 丰富的跨学科培训历史，在当前的资助周期内取得了显着的成功。 过去 4 年零 9 个月，12 名研究员接受或正在接受 MAGEC 培训，其中 2 名； 毕业学员获得教职，双双获得K12奖学金，其中一名获得两项 另外五名毕业生正在从事研究密集型工作。 学员发表了 56 篇出版物，其中 30 篇作为第一作者。 续签计划将支持 6 名博士后研究员。 MAGEC 计划的培训期限为 3 年，对该计划的持续支持至关重要。 维持其成功并扩大其对培养新一代分子和遗传学精英的影响 癌症流行病学家和精准医学和预防新时代的领导者。

项目成果

Outcomes of robotic-assisted liver surgery versus laparoscopic liver surgery for treatment of stage I hepatocellular carcinoma.

• DOI: 10.1002/cncr.33979
• 发表时间: 2022-02-15
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Duong, Linh M.;Cai, Hui;Shrubsole, Martha J.;Bailey, Christina E.;Idrees, Kamran;Shu, Xiao-Ou
• 通讯作者: Shu, Xiao-Ou

Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes.

在线虫中，饮食限制可以改善年迈父母的健康状况，但会降低其后代的健康状况。

• DOI: 10.1093/gerona/glz276
• 发表时间: 2020
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Mautz,BrianS;Lind,MartinI;Maklakov,AlexeiA
• 通讯作者: Maklakov,AlexeiA

Population Stratification in Genetic Association Studies.

• DOI: 10.1002/cphg.48
• 发表时间: 2017-10-18
• 期刊: Current protocols in human genetics
• 作者: Hellwege JN;Keaton JM;Giri A;Gao X;Velez Edwards DR;Edwards TL
• 通讯作者: Edwards TL

Novel Agents for the Management of Endocrine Resistant Breast Cancer.

治疗内分泌耐药乳腺癌的新药。

• DOI: 10.1007/s12609-018-0298-3
• 发表时间: 2018
• 期刊: Current breast cancer reports
• 影响因子: 0.9
• 作者: Reid-Lawrence,Sonya;Mayer,IngridA
• 通讯作者: Mayer,IngridA