Calcium intake and lung cancer: effect modification by sex and smoking status

钙摄入量与肺癌：性别和吸烟状况的影响

• 批准号: 9248754
• 负责人: XIAO-Ou SHU
• 金额: $ 3.1万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9248754
• 关键词: Calcium; intake; lung; cancer; effect

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer deaths worldwide and in the United States. Although cigarette smoking is the major cause, up to 25% of lung cancer cases are never smokers and female never smokers have a higher risk of incident lung cancer than male never smokers. The etiology of non-smoking-related lung cancer is poorly understood. Nutritional factors may affect multiple steps in lung carcinogenesis and cancer progression. Using data from the Shanghai Women's Health Study (SWHS), a large population-based, prospective cohort study in China, we recently reported a strong inverse association between dietary calcium intake and lung cancer risk among female never smokers (34% risk reduction for the top 25% of calcium intake compared with the bottom 25%). Our study is the first prospective study to report this finding, which needs to be confirmed in other populations. Calcium may interact with vitamin D and estrogens in carcinogenesis, but this hypothesis has not been investigated for non-smoking-related lung cancer. We propose here to conduct a pooling analysis involving thirteen large prospective cohorts and including approximately two million men and women from the United States and countries in Europe and Asia. The specific aims of this study are: 1) to prospectively investigate whether calcium intake is associated with the risk of non-smoking-related or smoking- related lung cancer and to evaluate whether such associations differ by sex and 2) to evaluate whether associations between calcium intake and lung cancer risk among female never smokers are modified by race/ethnicity, major determinants of vitamin D status, menopausal status, or hormone therapy use. This proposed study, with its large sample size, wide range of calcium intake, and previously-collected detailed exposure and covariate data, is extremely cost-efficient and provides an exceptional opportunity to comprehensively evaluate the association of calcium intake with the risk of non-smoking-related lung cancer. The infrastructure and networks established by this project would set the stage for future international collaborations on lung cancer risk and prognosis. 1

描述（由申请人提供）：肺癌是全球和美国癌症死亡的主要原因。尽管吸烟是主要原因，但多达25％的肺癌病例从未吸烟，而女性从未吸烟的肺癌风险高于从未吸烟的肺癌。对非吸烟相关的肺癌的病因鲜为人知。营养因素可能会影响肺癌发生和癌症进展的多个步骤。使用上海妇女健康研究（SWHS）的数据，这是一项基于人群的大型前瞻性队列研究，我们最近报道了女性永不吸烟者的饮食钙摄入量与肺癌风险之间存在牢固的反相关性（与最低25％相比，钙摄入量的前25％的钙降低34％的风险降低了34％）。我们的研究是报告这一发现的第一项前瞻性研究，需要在其他人群中确认。钙可能与癌变中的维生素D和雌激素相互作用，但尚未研究与无吸烟相关的肺癌的假设。我们在这里建议进行涉及13个大型前瞻性队列的集合分析，其中包括来自美国以及欧洲和亚洲国家的大约200万男女。 The specific aims of this study are: 1) to prospectively investigate whether calcium intake is associated with the risk of non-smoking-related or smoking- related lung cancer and to evaluate whether such associations differ by sex and 2) to evaluate whether associations between calcium intake and lung cancer risk among female never smokers are modified by race/ethnicity, major determinants of vitamin D status, menopausal status, or hormone therapy use.这项拟议的研究具有较大的样本量，广泛的钙摄入量以及先前收集的详细暴露和协变量数据，其成本效益极高，提供了一个非凡的机会，可以全面评估钙摄入量与非吸烟相关的肺癌的风险。该项目建立的基础设施和网络将为未来关于肺癌风险和预后的国际合作奠定阶段。 1