Calcium intake and lung cancer: effect modification by sex and smoking status

钙摄入量与肺癌：性别和吸烟状况的影响

• 批准号: 9248754
• 负责人: XIAO-Ou SHU
• 金额: $ 3.1万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9248754
• 关键词: Calcium; intake; lung; cancer; effect

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer deaths worldwide and in the United States. Although cigarette smoking is the major cause, up to 25% of lung cancer cases are never smokers and female never smokers have a higher risk of incident lung cancer than male never smokers. The etiology of non-smoking-related lung cancer is poorly understood. Nutritional factors may affect multiple steps in lung carcinogenesis and cancer progression. Using data from the Shanghai Women's Health Study (SWHS), a large population-based, prospective cohort study in China, we recently reported a strong inverse association between dietary calcium intake and lung cancer risk among female never smokers (34% risk reduction for the top 25% of calcium intake compared with the bottom 25%). Our study is the first prospective study to report this finding, which needs to be confirmed in other populations. Calcium may interact with vitamin D and estrogens in carcinogenesis, but this hypothesis has not been investigated for non-smoking-related lung cancer. We propose here to conduct a pooling analysis involving thirteen large prospective cohorts and including approximately two million men and women from the United States and countries in Europe and Asia. The specific aims of this study are: 1) to prospectively investigate whether calcium intake is associated with the risk of non-smoking-related or smoking- related lung cancer and to evaluate whether such associations differ by sex and 2) to evaluate whether associations between calcium intake and lung cancer risk among female never smokers are modified by race/ethnicity, major determinants of vitamin D status, menopausal status, or hormone therapy use. This proposed study, with its large sample size, wide range of calcium intake, and previously-collected detailed exposure and covariate data, is extremely cost-efficient and provides an exceptional opportunity to comprehensively evaluate the association of calcium intake with the risk of non-smoking-related lung cancer. The infrastructure and networks established by this project would set the stage for future international collaborations on lung cancer risk and prognosis. 1

描述（由申请人提供）：肺癌是全世界和美国癌症死亡的主要原因。尽管吸烟是主要原因，但高达 25% 的肺癌病例是从不吸烟者，并且从不吸烟的女性比从不吸烟的男性患肺癌的风险更高。对非吸烟相关肺癌的病因知之甚少。营养因素可能影响肺癌发生和癌症进展的多个步骤。利用上海妇女健康研究 (SWHS)（一项在中国开展的一项大规模人群前瞻性队列研究）的数据，我们最近报告称，在从不吸烟的女性中，膳食钙摄入量与肺癌风险之间存在很强的负相关性（吸烟者的风险降低了 34%）。钙摄入量最高的 25% 与最低的 25% 相比）。我们的研究是第一项报告这一发现的前瞻性研究，该发现需要在其他人群中得到证实。钙可能在致癌过程中与维生素 D 和雌激素相互作用，但这一假设尚未在与非吸烟相关的肺癌中得到研究。我们在此建议进行一项汇集分析，涉及 13 个大型前瞻性队列，其中包括来自美国以及欧洲和亚洲国家的约 200 万男性和女性。本研究的具体目的是：1) 前瞻性调查钙摄入量是否与非吸烟相关或吸烟相关肺癌风险相关，并评估这种相关性是否因性别而异；2) 评估不同性别之间的相关性是否存在差异。从不吸烟的女性的钙摄入量和肺癌风险因种族/民族、维生素 D 状态、更年期状态或激素治疗使用的主要决定因素而变化。这项拟议的研究样本量大、钙摄入量范围广，并且之前收集了详细的暴露和协变量数据，具有极高的成本效益，并为全面评估钙摄入量与非骨质疏松症风险之间的关系提供了一个绝佳的机会。与吸烟有关的肺癌。该项目建立的基础设施和网络将为未来肺癌风险和预后方面的国际合作奠定基础。 1