Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

范德比尔特癌症分子和遗传流行病学培训计划

• 批准号: 10228658
• 负责人: XIAO-Ou SHU
• 金额: $ 49.03万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228658
• 关键词: Molecular Epidemiology; Training Programs; cancer epidemiology; genetic epidemiology

ABSTRACT The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. While the field of cancer epidemiology is moving rapidly toward a new era in which interdisciplinary and multidisciplinary collaborative research is the central theme, there is a severe shortage of scientists working at the interfaces of epidemiology, molecular biology, and genetics. The Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt- MAGEC), launched in 2012 with NCI R25 funding, was designed to fill the gap with a goal of providing postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey- research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer. The specific aims of the Vanderbilt MAGEC program are: 1) To recruit exceptional, ethnically-diverse candidates with strong backgrounds in epidemiology, genetics, and/or biology. 2) To deliver individualized didactic training tailored to complement each trainee's prior training background and launch them into their desired career paths (molecular or genetic epidemiology of cancer). This training consists of courses, seminars, studios, journal clubs, conferences and research grant preparation. 3) To establish a multi-disciplinary mentor team for each trainee and integrate trainees into NCI- funded cancer epidemiology research projects. 4) To evaluate the impact of the Vanderbilt MAGEC program by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing high-quality papers in peer-reviewed journals and submitting a grant proposal to an internal or external funding agency based on the NIH format. Long-term outcomes include cancer research career placements and NIH grant funding. The MAGEC program, built upon an outstanding research and education training environment; a pool of 26 excellent, well-funded researchers and educators; 66 ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and a rich history of interdisciplinary training, has met with remarkable success during its first four grant years. A total of 9 fellows received or are currently receiving MAGEC training; of these, two obtained tenure track positions at major universities; one received a K99R00 award; and five submitted a career development application (K22, K99R00, K01 and DP5) or an R03 grant. MAGEC trainees contributed to 30 publications, 14 as first author. The program is mature and is in an excellent position to transition into a T32 training program. The renewal program will support 6 post-doctoral fellows, including 4 current fellows: one at Year 0, two at Year 1, and one each at Year 2, 3 and 4 levels. Expected training duration for the MAGEC program is 3 years. Continued support of the program is essential for sustaining its success and extending its impact on training a new generation of elite molecular and genetic cancer epidemiologists and leaders in the new era of precision medicine and prevention.

抽象的 分子生物学和遗传学技术和知识的快速发展和进步 导致癌症病因学研究取得重大突破。虽然癌症流行病学领域正在不断发展 迅速迈向以跨学科、多学科协作研究为中心的新时代 主题，严重缺乏从事流行病学、分子生物学、 和遗传学。范德比尔特癌症分子和遗传流行病学培训计划（范德比尔特- MAGEC）于 2012 年在 NCI R25 资助下推出，旨在填补这一空白，目标是提供 来自不同学科的博士后研究员，拥有方法论工具、实用实验室和调查- 开展独立研究所需的研究知识、实践研究和资助写作经验 从事癌症分子和遗传流行病学的职业。范德比尔特 MAGEC 的具体目标 计划包括： 1) 招募具有深厚流行病学背景的优秀、多种族候选人， 遗传学和/或生物学。 2) 提供个性化的教学培训，以补充每位学员的能力 先前的培训背景并引导他们进入他们想要的职业道路（分子或遗传流行病学 癌症）。该培训包括课程、研讨会、工作室、期刊俱乐部、会议和研究资助 准备。 3) 为每位学员建立多学科导师团队，将学员融入NCI- 资助癌症流行病学研究项目。 4) 评估范德比尔特 MAGEC 计划的影响 通过跟踪短期和长期结果。所有学员的预期短期成果包括出版 在同行评审期刊上发表高质量论文并向内部或外部资助机构提交资助提案 基于 NIH 格式的机构。长期成果包括癌症研究职业安置和 NIH 拨款。 MAGEC 项目建立在出色的研究和教育培训环境之上；一个 拥有 26 名优秀、资金充足的研究人员和教育工作者； 66 个正在进行的前沿研究项目； 特殊数据/生物样本和人口资源；和丰富的跨学科培训历史，满足了 在其前四年的拨款年度中取得了显着的成功。共有 9 名研究员已获得或正在获得 MAGEC 培训；其中，两人获得了主要大学的终身教职；其中一个收到了 K99R00 奖;五人提交了职业发展申请（K22、K99R00、K01 和 DP5）或 R03 补助金。 MAGEC 学员发表了 30 篇出版物，其中 14 篇作为第一作者。该方案已经成熟并且处于良好状态 过渡到 T32 培训计划的职位。更新计划将支持6名博士后研究员， 包括 4 名现任研究员：一名 0 年级人员，两名一年级人员，以及 2、3 和 4 年级各一名。预期的 MAGEC 计划的培训期限为 3 年。该计划的持续支持对于 维持其成功并扩大其对培养新一代分子和遗传学精英的影响 癌症流行病学家和精准医学和预防新时代的领导者。