Shanghai Men's Health Study

上海男性健康研究

• 批准号: 8922795
• 负责人: XIAO-Ou SHU
• 金额: $ 37.27万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-18 至 2016-04-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8922795
• 关键词: Address; Area; Asia; Asians; Biological; Biological Markers; Biological Sciences; Blood; Cancer Etiology; Cancer Patient; Cause of Death; Chinese People; Chronic Disease; Cohort Studies; Collaborations; Colon; Colorectal Cancer; Communities; Country; Data; Data Collection; Databases; Diagnosis; Dietary intake; Disease; Disease Outcome; Epidemiologic Studies; Epidemiology; Exposure to; Funding; Future; Genetic; Genetic Predisposition to Disease; Grant; Health; Health Information System; Incidence; Interview; Investigation; Investments; Journal of the National Cancer Institute; Journals; Life Style; Liver; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Manuscripts; Medicine; Nature; New England; Outcome; Paper; Participant; Pattern; Peer Review; Persons; Population Study; Prostate; Protocols documentation; Publications; Publishing; Quality Control; Quality of life; Recruitment Activity; Rectum; Recurrence; Registries; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sample Size; Sampling; Site; Specimen; Stomach; Surveys; Survivors; Time; Tissue Sample; Training; Tumor Tissue; Update; Urine; Vital Statistics; biobank; cancer prevention; cancer risk; cancer therapy; cohort; common treatment; follow-up; genetic epidemiology; lifestyle factors; male health; malignant stomach neoplasm; member; men; mortality; neoplasm registry; population based; response; success; survivorship; tumor; web site

DESCRIPTION (provided by applicant): The Shanghai Men's Health Study (SMHS), funded by NCI since 2001 (R0I CA082729), is a population based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed through multiple in-person follow-up surveys and record linkages. Over the years, data and biological samples collected in the SMHS have been used to evaluate many important etiologic hypotheses and support multiple studies, including over 25 consortium projects. To both sustain and expand its resources and success, we are applying for infrastructure funding with the following specific aims: 1) Continue the follow-up of this cohort for cancer incidence and cause-specific mortality and expand the cohort's resources by conducting in-person interviews to update information on exposures and selected disease outcomes; 2) Maintain the data bank and biorepository of the SMHS and implement quality control protocols to maximize the value of its resources for scientific research; 3) Collect blood and urine samples from 6,000 study participants to enhance our ability to study intermediate disease biomarkers as a consequence of exposures assessed at the baseline and subsequent follow-ups; 4) Collect information related to the diagnosis and treatment of common chronic diseases for cohort members by searching the database of an electronic Health Information System covering the study population; 5) Collect tumor tissue samples and detailed information on cancer treatment, recurrence, and survivorship for participants diagnosed with cancers of the lung, stomach, colon/rectum, liver, and prostate, the five most common cancers in the cohort, as well as collect post-diagnosis lifestyle factor and quality of life information for survivors of stomach, colon/rectum, and prostate cancer; 6).To build a website to promote and facilitate collaborations among the broader community of cancer researchers, to disseminate research findings, and to attract and cultivate new investigators. The SMHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in any other existing cohort study. Continuing follow-up of the cohort and expansion of its resources would further increase the value of the SMHS for a long-term epidemiologic study of cancer and other chronic diseases.

描述（由申请人提供）：上海男性健康研究 (SMHS) 自 2001 年起由 NCI 资助 (R0I CA082729)，是一项基于人群的队列研究，研究对象为 2002 年至 2006 年间招募的 61,491 名男性，并通过多项研究进行跟踪。人员跟踪调查并记录联系。多年来，SMHS 收集的数据和生物样本已被用于评估许多重要的病因学假设并支持多项研究，包括超过 25 个联合项目。为了维持和扩大其资源和成功，我们正在申请基础设施资金，其具体目标如下： 1) 继续跟踪该队列的癌症发病率和特定原因死亡率，并通过亲自进行实地调查来扩大该队列的资源进行访谈以更新有关暴露和选定疾病结果的信息； 2）维护SMHS的数据库和生物样本库并实施质量控制协议，以最大限度地发挥其科学研究资源的价值； 3) 收集 6,000 名研究参与者的血液和尿液样本，以增强我们研究中间疾病生物标志物的能力，这些生物标志物是在基线和后续随访中评估暴露的结果； 4）通过检索覆盖研究人群的电子健康信息系统数据库，收集队列成员常见慢性病诊断和治疗的相关信息； 5) 收集被诊断患有肺癌、胃癌、结肠/直肠癌、肝癌和前列腺癌（队列中五种最常见癌症）的参与者的肿瘤组织样本以及有关癌症治疗、复发和生存的详细信息，并收集胃癌、结肠癌/直肠癌和前列腺癌幸存者的诊断后生活方式因素和生活质量信息； 6).建立一个网站，以促进和促进更广泛的癌症研究人员之间的合作，传播研究成果，并吸引和培养新的研究人员。 SMHS 拥有庞大的样本量、丰富的资源以及独特的暴露模式和疾病谱，为解决许多其他现有队列研究无法充分研究的重要假设提供了绝佳的机会。对该队列的持续跟踪和资源的扩展将进一步增加 SMHS 在癌症和其他慢性疾病的长期流行病学研究中的价值。