The Cleveland Digestive Diseases Research Core Center (DDRCC)

克利夫兰消化疾病研究核心中心 (DDRCC)

• 批准号: 10634300
• 负责人: Fabio Cominelli
• 金额: $ 10万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634300
• 关键词: Address; Affect; Alcoholic Hepatitis; Alcohols; Applications Grants; Area; Award; Barrett Esophagus; Basic Science; Biological Response Modifier Therapy; Biomedical Research; Cirrhosis; Clinic; Clinical; Colitis; Collaborations; Colon Carcinoma; Colorectal Cancer; Cost efficiency; Data; Development; Digestive System Disorders; Education; Elements; Endoscopy; Environment; Experimental Models; Faculty; Fostering; Foundations; Funding; Gastrointestinal Diseases; Generations; Genetic Determinism; Grant; Growth; HIV therapy; Health; Hepatitis; Histologic; Histology; Human; Human Resources; Ileitis; Image; Inflammation; Inflammatory Bowel Diseases; Institution; International; Investigation; Laboratories; Leadership; Liver diseases; Malignant neoplasm of esophagus; Mentors; Mentorship; Metabolic syndrome; Metabolism; Midwestern United States; Mission; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Occupational activity of managing finances; Organoids; Pathogenicity; Patients; Peer Review; Persons; Privatization; Process; Quality Control; Records; Research; Research Institute; Research Personnel; Research Project Grants; Resource Sharing; Resources; Science; Series; Services; Study Section; Surveys; Technical Expertise; Techniques; Technology; Time; Tissue Banks; Training; Translations; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; animal imaging; base; biobank; biological adaptation to stress; carcinogenesis; career development; colitis associated cancer; cost effective; design; digital pathology; epithelial repair; experience; gut dysbiosis; innovation; intestinal epithelium; liver imaging; medical schools; meetings; member; microbial; minority investigator; mouse model; multidisciplinary; new technology; operation; opioid use; programs; ranpirnase; sarcopenia; symposium; tumorigenesis

CLEVELAND DDRCC OVERALL PROJECT SUMMARY This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators, 3) attract established investigators not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center currently includes 47 full members and 35 associate members from 25 different academic departments across CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer- reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions. The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels of usage by Center members and promoted important scientific discoveries in digestive diseases during the previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge advanced services and technologies that may not otherwise be available to Center investigators. The Core laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility Program to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science (IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is to increase the availability of Core resources for Center members, and to foster research, collaborations, and new directions in digestive disease research, leading to important scientific discoveries.

克利夫兰DDRCC总体项目摘要 该竞争性更新申请是为克利夫兰消化疾病获得持续资金 研究核心中心（DDRCC），这是Case Western Reserve University的一项综合努力 （CWRU）和克利夫兰诊所基金会（CCF）。克利夫兰DDRCC的任务是：1）增强 中心研究人员的研究能力，2）制定和实施计划，以支持独立 年轻研究人员的发展，3）吸引目前尚未参与消化的既定研究人员 疾病研究将其专业知识应用于这一重要的调查领域，4）促进翻译 临床领域的基础研究发现。这个跨机构和多学科中心 目前包括来自25个不同学术部门的47名正式成员和35位同学成员 CWRU和CCF，代表上一个融资周期中稳定的扩张。在一起，这些 调查人员组成了该中心的研究基础，目前包括1730万美元的同行 审查了与联邦和基金会的补助金（52 NIH，5 DOD/VA，10个私人基金会赠款）特别相关 克利夫兰DDRCC的两个科学主题：消化性炎症/肿瘤发生和肝脏 疾病/代谢。这两个编程领域具有合作的历史记录很强 在CWRU和CCF进行调查，并在上一次协作中显示出显着增长 资金周期。该中心享有强大的机构支持，包括大量匹配的承诺 CWRU和CCF的资金都增加了这两个机构的消化疾病研究的影响。 该中心包括三个生物医学研究核心，以支持这一强大的研究基础：1）生物座席 核心，2）组织学/成像核心和3）鼠标模型核心，所有这些核心均显示出高水平 中心成员使用的用法，并在消化疾病中促进了重要的科学发现 以前的资金周期。每个核心都包含一组最好提供的大量标准服务 作为可以优化成本效益和质量控制的共享资源，以及更前沿的 中心调查人员可能无法使用的高级服务和技术。核心 实验室与行政核心的接口，该核心也支持成功的飞行员和可行性 促进新手消化领域的研究人员促进创新研究项目的计划 疾病。行政核心监督克利夫兰DDRCC的财务管理和运营 并支持临床元素，以及支持会议的动态丰富计划 中西部DDRCC研究联盟和两个克利夫兰国际消化教育和科学 （想法）在上一个资金周期中的座谈会。克利夫兰DDRCC的总体目标是 增加中心成员的核心资源的可用性，并促进研究，合作和新 消化疾病研究的方向，导致重要的科学发现。