Mouse Models Core D

鼠标型号 Core D

基本信息

批准号：
10555245
负责人：
Fabio Cominelli
金额：
$ 23.76万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555245
关键词：
3-Dimensional Adoptive Transfer Anesthesia procedures Animals Area Bone Marrow Breeding CRISPR/Cas technology Chemicals Chimera organism Chronic Clinic Colitis Colitis associated colorectal cancer Collaborations Colonic Neoplasms Colonic inflammation Communities Complex Consult Consultations Core Facility Cost Savings Couples Development Digestive System Disorders Disease Education Endoscopy Evaluation Evolution Fostering Funding Funding Opportunities Genes Goals Hemoglobin Hepatitis Hepatocarcinogenesis Histology Human Resources Ileocolitis Image Immunologics Individual Inflammation Inflammatory Investigation Joints Large Intestine Light Liver Liver diseases Magnetic Resonance Imaging Mediating Metabolic Diseases Metabolism Methodology Methods Midwestern United States Modeling Mus Mutation Obesity Pathogenesis Performance Peroxidases Productivity Proteins Protocols documentation Publications Qualifying RNA Randomized Recovery Reproducibility Research Research Institute Research Personnel Research Project Grants Research Support Resolution Resource Sharing Resources Sampling Service delivery model Services Small Intestines Standardization Surveys System Techniques Technology Testing Tissue Harvesting Tissues Training Universities Visual Visualization cell type chromoscopy cohort commune cost cost effective digital effectiveness evaluation experimental group experimental study flexibility gastrointestinal gut inflammation imaging capabilities improved in vivo liver inflammation meetings member metabolic abnormality assessment metabolic phenotype mouse model nano-string new technology operation preclinical study programs research and development research facility treatment effect treatment group tumor tumorigenesis

项目摘要

MOUSE MODELS CORE D PROJECT SUMMARY The objective of the Cleveland DDRCC Mouse Models Core is to provide a comprehensive set of cost-effective services and shared resources to DDRCC investigators that augments their performance of in vivo studies focused on the pathogenesis of Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. The overall goal of this Core is to provide centralized mouse modeling services that will enhance the pace of in vivo digestive disease-related research at Case Western Reserve University and the Cleveland Clinic Lerner Research Institute and provide communal, cost-effective access to unique mouse models on intestinal inflammation and liver disease, thus resulting in new research projects, funding opportunities, and collaborations in these areas of investigation. During the past funding cycle, the Core has been successful, with an increase in the number of Core users and several important publications supported by the Core. The Cleveland DDRCC Mouse Models Core achieves these goals through the following specific aims: (1) Provide experimental cohorts of SAMP1/YitFc and TNFARE mice to Center members, other DDRCCs, and the US scientific community; (2) Educate, consult, and train DDRCC investigators in the use of various mouse modeling techniques; (3) Provide high-resolution murine video endoscopy with well-validated scoring of intestinal inflammation and colonic tumors; (4) Quantify murine intestinal inflammation by 3-D stereomicroscopy with assessment of myeloperoxidase activity; and (5) Interface with the Case Mouse Metabolic Phenotyping Center to support DDRCC investigators performing murine metabolic studies and provide joint educational programs on new technologies available for the study of murine inflammatory and metabolic diseases. The DDRCC Mouse Models Core Steering Committee meets monthly to discuss operational issues. The Core presents its operations to the DDRCC Executive Committee at their quarterly meetings to evaluate the effectiveness of existing services against the evolving needs of the DDRCC membership so that the Core brings the most benefit to the Center members and the scientific themes of the Cleveland DDRCC. Thus, the Mouse Models Core benefits DDRCC members by providing a combination of uniquely available resources and cost-effective services that facilitate the development of research related to digestive diseases in the Cleveland scientific community and beyond.

鼠标模型 Core D 项目摘要 Cleveland DDRCC 鼠标模型核心的目标是提供一整套具有成本效益的为 DDRCC 研究人员提供服务和共享资源，增强他们体内研究的表现专注于消化道炎症/肿瘤发生和肝病/代谢的发病机制。该核心的总体目标是提供集中式小鼠建模服务，以加快体内实验的步伐凯斯西储大学和克利夫兰勒纳诊所的消化系统疾病相关研究研究所并提供公共的、具有成本效益的途径来获得独特的肠道小鼠模型炎症和肝病，从而产生新的研究项目、资助机会和在过去的资助周期中，核心在这些研究领域的合作取得了成功，随着 Core 用户数量的增加以及 Core 支持的一些重要出版物。 Cleveland DDRCC 鼠标模型核心通过以下具体目标实现这些目标：(1) 提供向中心成员、其他 DDRCC 和美国提供 SAMP1/YitFc 和 TNFARE 小鼠实验队列科学界；(2) 对 DDRCC 研究人员进行有关使用各种小鼠的教育、咨询和培训建模技术；（3）提供高分辨率的小鼠视频内窥镜检查，并经过充分验证的评分 (4) 通过 3-D 量化小鼠肠道炎症立体显微镜法评估髓过氧化物酶活性；以及 (5) 与案例小鼠的接口代谢表型中心支持 DDRCC 研究人员进行小鼠代谢研究和提供可用于研究小鼠炎症和疾病的新技术的联合教育计划 DDRCC 小鼠模型核心指导委员会每月召开一次会议进行讨论。核心在季度报告中向 DDRCC 执行委员会介绍其运营情况。召开会议，根据 DDRCC 不断变化的需求评估现有服务的有效性会员资格，以便核心为中心成员和中心的科学主题带来最大的利益因此，鼠标模型核心通过提供以下组合使 DDRCC 成员受益。独特的可用资源和具有成本效益的服务，促进相关研究的发展克利夫兰科学界及其他地区的消化系统疾病。