The Cleveland Digestive Diseases Research Core Center (DDRCC)

克利夫兰消化疾病研究核心中心 (DDRCC)

• 批准号: 10789648
• 负责人: Fabio Cominelli
• 金额: $ 39.34万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10789648
• 关键词: Acceleration; Address; Affect; Alcoholic Hepatitis; Alcohols; Applications Grants; Area; Award; Barrett Esophagus; Basic Science; Biological Response Modifier Therapy; Biomedical Research; Cirrhosis; Clinic; Clinical; Colitis; Collaborations; Colon Carcinoma; Colorectal Cancer; Cost efficiency; Data; Development; Digestive System Disorders; Education; Elements; Endoscopy; Environment; Experimental Models; Faculty; Fostering; Foundations; Funding; Gastrointestinal Diseases; Generations; Genetic Determinism; Grant; Growth; HIV therapy; Health; Hepatitis; Histologic; Histology; Human; Human Resources; Hyperammonemia; Ileitis; Image; Inflammation; Inflammatory Bowel Diseases; Institution; International; Investigation; Laboratories; Leadership; Liver diseases; Malignant neoplasm of esophagus; Mentors; Mentorship; Metabolic syndrome; Metabolism; Midwestern United States; Mission; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Occupational activity of managing finances; Organoids; Pathogenicity; Patients; Peer Review; Persons; Privatization; Process; Quality Control; Records; Research; Research Institute; Research Personnel; Research Project Grants; Resource Sharing; Resources; Science; Series; Services; Study Section; Surveys; Technical Expertise; Techniques; Technology; Time; Tissue Banks; Training; Translations; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; animal imaging; base; biobank; biological adaptation to stress; carcinogenesis; career development; colitis associated cancer; cost effective; design; digital pathology; epithelial repair; experience; gut dysbiosis; innovation; intestinal epithelium; liver imaging; medical schools; meetings; member; microbial; minority investigator; mouse model; multidisciplinary; new technology; operation; opioid use; programs; sarcopenia; symposium; tumorigenesis

CLEVELAND DDRCC OVERALL PROJECT SUMMARY This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators, 3) attract established investigators not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center currently includes 47 full members and 35 associate members from 25 different academic departments across CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer- reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions. The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels of usage by Center members and promoted important scientific discoveries in digestive diseases during the previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge advanced services and technologies that may not otherwise be available to Center investigators. The Core laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility Program to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science (IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is to increase the availability of Core resources for Center members, and to foster research, collaborations, and new directions in digestive disease research, leading to important scientific discoveries.

克利夫兰 DDRCC 总体项目摘要 此竞争性更新申请旨在为克利夫兰消化疾病中心获得持续资助 研究核心中心 (DDRCC)，由凯斯西储大学共同努力 （CWRU）和克利夫兰诊所基金会（CCF）。克利夫兰 DDRCC 的使命是： 1) 增强 中心研究人员的研究能力，2）制定和实施支持独立研究的计划 年轻研究人员的发展，3）吸引目前不参与消化领域的成熟研究人员 疾病研究将其专业知识应用到这一重要的研究领域，以及 4) 促进翻译 基础研究发现到临床领域的影响。这个跨机构、多学科的中心 目前包括来自 25 个不同学术部门的 47 名正式会员和 35 名准会员 CWRU 和 CCF 代表了上一个融资周期中的稳定扩张。在一起，这些 该中心的研究基地目前由 1,730 万美元的同行研究人员组成。 审查了专门与以下方面相关的联邦和基金会拨款（52 项 NIH、5 项 DOD/VA、10 项私人基金会拨款） 克利夫兰 DDRCC 的两个科学主题：消化道炎症/肿瘤发生和肝脏 疾病/新陈代谢。这两个计划领域有着良好的合作历史记录 CWRU 和 CCF 的调查表明，在上一届会议期间，合作取得了显着进展 资金周期。该中心享有强大的机构支持，包括重大匹配的承诺 CWRU 和 CCF 提供资金，以提高两个机构消化疾病研究的影响力。 该中心包括三个生物医学研究核心来支持这个强大的研究基地：1）生物样本库 核心，2) 组织学/成像核心，以及 3) 小鼠模型核心，所有这些都表现出高水平 中心成员的使用，并在消化系统疾病方面促进了重要的科学发现 上一个融资周期。每个核心都包含一组最好提供的大容量标准服务 作为共享资源，可以优化成本效率和质量控制，以及更前沿的 中心调查人员可能无法获得先进的服务和技术。核心 实验室与管理核心接口，该核心也支持成功的试点和可行性 促进消化领域新研究人员创新研究项目的计划 疾病。行政核心负责监督克利夫兰 DDRCC 的财务管理和运营 并支持临床元素，以及支持会议的动态丰富计划 中西部 DDRCC 研究联盟和两个克利夫兰国际消化教育和科学 (IDEAS) 上一个资助周期期间的研讨会。克利夫兰 DDRCC 的总体目标是 增加中心成员的核心资源可用性，并促进研究、合作和新的 消化疾病研究方向，导致重要的科学发现。