Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)

亚裔美国人预防研究：人口组学流行病学队列 (ARISE)

基本信息

批准号：
10724884
负责人：
Ann Hsing
金额：
$ 57.65万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10724884
关键词：
Address Affect Age American Anxiety Area Asian Asian Americans Asian population Biological Assay Biology Biosensing Techniques Cardiometabolic Disease Cardiovascular Diseases Caucasians Chinese Chronic Disease Clinical Clinical Markers Clinical assessments Cohort Studies Collaborations Collection Communities County Data Data Collection Development Diabetes Mellitus Diagnosis Dimensions Discrimination Disease Dyslipidemias Educational workshop Electronic Mail Enrollment Epidemiology Ethnic Origin Ethnic Population Filipino Future Genetic Variation Guidelines Health Health Sciences Heart Rate Hypertension Immigrant Immigration Information Dissemination Knowledge Life Linguistics Low income Measures Mental Health Mental disorders Metabolic syndrome Mood Disorders National Heart, Lung, and Blood Institute Native Hawaiian or Other Pacific Islander Neighborhoods Newsletter Obesity Obstructive Sleep Apnea Outcome Outcome Assessment Participant Patient Self-Report Pattern Personal Satisfaction Persons Phenotype Photoplethysmography Physical activity Population Prediabetes syndrome Prevalence Prevention Research Prevention strategy Procedures Prospective cohort Prospective, cohort study Protocols documentation Psychology Psychosocial Factor Psychosocial Influences Recording of previous events Refugees Reporting Research Research Personnel Resources Risk Assessment Risk Factors Sampling San Francisco Site Sleep Sleep Architecture Sleep Disorders Stress Stroke Subgroup Surveys Technology Technology Assessment Time Trauma United States United States National Institutes of Health Variant Vietnamese Viral hepatitis Woman cardiometabolic risk cardiometabolism cohort digital technology disorder prevention disorder risk epidemiologic data experience follow-up heart rate variability imaging study improved innovation low health literacy marginalization member men multi-ethnic multidisciplinary multiple omics non-alcoholic fatty liver disease participant retention patient engagement perceived stress physical conditioning poor health outcome population based population health psychosocial recruit screening program sensor sleep quality social media social stress socioeconomic disadvantage socioeconomics statistics temporal measurement wearable device

项目摘要

Project Summary We propose to contribute a Bay Area, population-based prospective cohort to a nationwide cohort study of Asian American (AsA) men and women to address major gaps in evidence on the correlates and determinants of disease risk and health. We will recruit, characterize, and follow Chinese, Filipino, and Vietnamese Americans, three understudied AsA ethnic groups whose populations are rapidly expanding in the United States. Specifically, we will recruit 2,100 Chinese, Filipino, and Vietnamese Americans (700 of each ethnic group) in the San Francisco Bay Area to characterize cardiometabolic profiles and psychosocial and other health factors through extensive surveys, clinical assessments and assays, imaging studies, multi-omics, and digital technology. Although disease patterns and risk factors appear to vary among different AsA groups, previous research suggests that AsAs are highly affected by cardiometabolic disorders such as diabetes, hypertension, dyslipidemia, cardiovascular disease, stroke, non-alcoholic fatty liver disease, and obesity, as well as underdiagnosed mental health conditions and psychosocial issues related to immigration trauma, discrimination, and marginalization. However, epidemiological data on individual AsA groups are sparse, and most clinical guidelines and treatments are based on data derived from Caucasians. Our UG3/UH3 study site will collaborate with the Coordinating Center (U24), other study sites, and NHLBI to develop a large cohort of 10,000 members to characterize risk factors and disease patterns in individual AsA ethnic groups. The specific aims of the proposed study are to 1) contribute to the development of a Common Protocol for the study in collaboration with NHLBI, U24, and other UG3/UH3 investigators and establish a state-of-the-art populomics cohort; 2) measure the prevalence or distribution of baseline self-reported health and risk factors and clinical markers in each ethnic group and compare across ethnic groups; and 3) determine relationships among baseline risk factors in each AsA ethnic group, including self-reported stress and sleep as well as heart rate variability-derived sleep quality and stress from wearable biosensing data, with subsequent (incident) health outcomes during follow-up. This proposed study is innovative in its in-depth exposome phenotyping through comprehensive surveys that will include assessments of well-being and anxiety in addition to traditional risk factors, baseline clinical assessments, advanced digital technology, and integrative omics to understand the intersections of epidemiology, biology, psychology, and technology in physical and mental health. We will leverage these innovations alongside Stanford’s world-class resources in population health sciences to uncover critical cardiometabolic and psychosocial factors underlying health and disease in AsAs. This study will advance health and disease prevention and treatment and will lead to improved health and well-being outcomes for AsAs. 1

项目概要我们建议为一项全国性队列研究贡献一个基于湾区人口的前瞻性队列亚裔美国人 (AsA) 男性和女性要解决相关因素和决定因素方面证据的重大差距我们将招募、描述和跟踪中国人、菲律宾人和越南人。美国人，三个未被充分研究的 AsA 族群，其人口在美国迅速增长具体来说，我们将招募 2,100 名华裔、菲律宾裔和越南裔美国人（每个族裔 700 名）。小组）在旧金山湾区表征心脏代谢特征和心理社会及其他通过广泛的调查、临床评估和分析、影像学研究、多组学和尽管不同 AsA 群体的疾病模式和危险因素似乎有所不同，先前的研究表明，AsAs 受到糖尿病等心脏代谢疾病的高度影响，高血压、血脂异常、心血管疾病、中风、非酒精性脂肪肝、肥胖等以及与移民创伤相关的心理健康状况和社会心理问题未被充分诊断，然而，关于个别 AsA 群体的流行病学数据很少，并且大多数临床指南和治疗都是基于我们的 UG3/UH3 研究网站的数据。将与协调中心 (U24)、其他研究中心和 NHLBI 合作开发一大批 10,000 名成员来描述各个 AsA 族群的风险因素和疾病模式。拟议研究的目的是 1) 为该研究制定共同方案与 NHLBI、U24 和其他 UG3/UH3 研究人员合作，建立最先进的人口组学 2) 测量基线自我报告的健康和危险因素以及临床的患病率或分布每个种族群体中的标记并在不同种族群体之间进行比较；3) 确定之间的关系每个 AsA 族群的基线危险因素，包括自我报告的压力、睡眠以及心率来自可穿戴生物传感数据的变异性睡眠质量和压力，以及随后的（事件）健康状况这项拟议的研究在深入的暴露组表型分析方面具有创新性。除了传统风险之外，还包括对幸福感和焦虑的评估的全面调查因素、基线临床评估、先进的数字技术和综合组学来了解流行病学、生物学、心理学和技术在身心健康方面的交叉点。利用这些创新以及斯坦福大学在人口健康科学方面的世界一流资源这项研究揭示了 AsAs 健康和疾病的关键心脏代谢和社会心理因素。将促进健康和疾病的预防和治疗，并改善健康和福祉 AsAs 的结果。 1