Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)

亚裔美国人预防研究：人口组学流行病学队列 (ARISE)

基本信息

批准号：
10724884
负责人：
Ann Hsing
金额：
$ 57.65万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10724884
关键词：
Address Affect Age American Anxiety Area Asian Asian Americans Asian population Biological Assay Biology Biosensing Techniques Cardiometabolic Disease Cardiovascular Diseases Caucasians Chinese Chronic Disease Clinical Clinical Markers Clinical assessments Cohort Studies Collaborations Collection Communities County Data Data Collection Development Diabetes Mellitus Diagnosis Dimensions Discrimination Disease Dyslipidemias Educational workshop Electronic Mail Enrollment Epidemiology Ethnic Origin Ethnic Population Filipino Future Genetic Variation Guidelines Health Health Sciences Heart Rate Hypertension Immigrant Immigration Information Dissemination Knowledge Life Linguistics Low income Measures Mental Health Mental disorders Metabolic syndrome Mood Disorders National Heart, Lung, and Blood Institute Native Hawaiian or Other Pacific Islander Neighborhoods Newsletter Obesity Obstructive Sleep Apnea Outcome Outcome Assessment Participant Patient Self-Report Pattern Personal Satisfaction Persons Phenotype Photoplethysmography Physical activity Population Prediabetes syndrome Prevalence Prevention Research Prevention strategy Procedures Prospective cohort Prospective, cohort study Protocols documentation Psychology Psychosocial Factor Psychosocial Influences Recording of previous events Refugees Reporting Research Research Personnel Resources Risk Assessment Risk Factors Sampling San Francisco Site Sleep Sleep Architecture Sleep Disorders Stress Stroke Subgroup Surveys Technology Technology Assessment Time Trauma United States United States National Institutes of Health Variant Vietnamese Viral hepatitis Woman cardiometabolic risk cardiometabolism cohort digital technology disorder prevention disorder risk epidemiologic data experience follow-up heart rate variability imaging study improved innovation low health literacy marginalization member men multi-ethnic multidisciplinary multiple omics non-alcoholic fatty liver disease participant retention patient engagement perceived stress physical conditioning poor health outcome population based population health psychosocial recruit screening program sensor sleep quality social media social stress socioeconomic disadvantage socioeconomics statistics temporal measurement wearable device

项目摘要

Project Summary We propose to contribute a Bay Area, population-based prospective cohort to a nationwide cohort study of Asian American (AsA) men and women to address major gaps in evidence on the correlates and determinants of disease risk and health. We will recruit, characterize, and follow Chinese, Filipino, and Vietnamese Americans, three understudied AsA ethnic groups whose populations are rapidly expanding in the United States. Specifically, we will recruit 2,100 Chinese, Filipino, and Vietnamese Americans (700 of each ethnic group) in the San Francisco Bay Area to characterize cardiometabolic profiles and psychosocial and other health factors through extensive surveys, clinical assessments and assays, imaging studies, multi-omics, and digital technology. Although disease patterns and risk factors appear to vary among different AsA groups, previous research suggests that AsAs are highly affected by cardiometabolic disorders such as diabetes, hypertension, dyslipidemia, cardiovascular disease, stroke, non-alcoholic fatty liver disease, and obesity, as well as underdiagnosed mental health conditions and psychosocial issues related to immigration trauma, discrimination, and marginalization. However, epidemiological data on individual AsA groups are sparse, and most clinical guidelines and treatments are based on data derived from Caucasians. Our UG3/UH3 study site will collaborate with the Coordinating Center (U24), other study sites, and NHLBI to develop a large cohort of 10,000 members to characterize risk factors and disease patterns in individual AsA ethnic groups. The specific aims of the proposed study are to 1) contribute to the development of a Common Protocol for the study in collaboration with NHLBI, U24, and other UG3/UH3 investigators and establish a state-of-the-art populomics cohort; 2) measure the prevalence or distribution of baseline self-reported health and risk factors and clinical markers in each ethnic group and compare across ethnic groups; and 3) determine relationships among baseline risk factors in each AsA ethnic group, including self-reported stress and sleep as well as heart rate variability-derived sleep quality and stress from wearable biosensing data, with subsequent (incident) health outcomes during follow-up. This proposed study is innovative in its in-depth exposome phenotyping through comprehensive surveys that will include assessments of well-being and anxiety in addition to traditional risk factors, baseline clinical assessments, advanced digital technology, and integrative omics to understand the intersections of epidemiology, biology, psychology, and technology in physical and mental health. We will leverage these innovations alongside Stanford’s world-class resources in population health sciences to uncover critical cardiometabolic and psychosocial factors underlying health and disease in AsAs. This study will advance health and disease prevention and treatment and will lead to improved health and well-being outcomes for AsAs. 1

项目摘要我们建议为一项全国范围的同类研究贡献一个湾区，基于人群的前瞻性队列亚裔美国人（ASA）男人和女人解决有关与决定者的主要证据的主要差距疾病风险和健康。我们将招募，特征和关注中文，菲律宾和越南美国人，三个理解的ASA种族，他们的人口正在统一迅速扩大国家。具体而言，我们将招募2,100名中国人，菲律宾和越南人（每个民族中有700个小组）在旧金山湾区的特征是心脏代谢概况以及社会心理和其他通过广泛的调查，临床评估和评估，成像研究，多词和数字技术。尽管疾病模式和危险因素在不同的ASA组中似乎有所不同，但先前的研究表明，ASA受到心脏代谢性疾病（例如糖尿病）的高度影响，高血压，血脂异常，心血管疾病，中风，非酒精性脂肪肝疾病和肥胖症，如以及与移民创伤有关的精神健康状况和心理社会问题的未诊断不足，歧视和边缘化。但是，关于个别ASA组的流行病学数据很少，并且大多数临床准则和治疗方法基于来自高加索人的数据。我们的UG3/UH3研究网站将与协调中心（U24），其他研究站点和NHLBI合作，以发展大量队列 10,000名成员来表征个别ASA族裔的危险因素和疾病模式。具体拟议的研究的目的是1）促进该研究的共同协议的发展与NHLBI，U24和其他UG3/UH3调查人员合作，并建立最先进的人口队列； 2）衡量基线自我报告的健康和危险因素以及临床的普遍性或分布每个种族的标记，并在各个种族中进行比较； 3）确定之间的关系每个ASA种族中的基线风险因素，包括自我报告的压力和睡眠以及心率可穿戴生物传感数据的变异性睡眠质量和压力，随后（事件）健康随访期间的结果。这项拟议的研究在其深入的外向表型中具有创新性全面的调查还包括对福祉和动画的评估，除了传统的风险因素，基线临床评估，先进的数字技术和集成的OMIC，以了解身体和心理健康中流行病学，生物学，心理学和技术的交集。我们将利用这些创新以及斯坦福大学的人口健康科学资源揭示ASA中健康和疾病的关键心脏代谢和社会心理因素。这项研究将提高健康和疾病的预防和治疗，并改善健康和福祉阿萨斯的结果。 1