The Mass-SIREN Group

Mass-SIRN 集团

• 批准号: 10620460
• 负责人: Joshua N Goldstein
• 金额: $ 10.87万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620460
• 关键词: Administrative Supplement; Boston; Childhood; Clinical Research; Clinical Trials Network; Emergency Care; Enrollment; Funding; General Hospitals; Hospitals; Institution; Israel; Ketamine; Massachusetts; Medical center; Medical emergency; Modeling; Network-based; New England; Office of Administrative Management; Patient Care; Patients; Pediatric Hospitals; Principal Investigator; Research Personnel; Site; Status Epilepticus; Universities; Vermont; Woman; Work; clinical center; clinical trial enrollment; improved; innovation; meetings; novel; programs; tertiary care

Project Summary/Abstract: This application will continue support for a New England based Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose to continue our integrated, collaborative team of high-volume tertiary care medical centers with expertise in emergency care clinical research. Our core institutions include Beth Israel Deaconess Medical Center (BIDMC), Boston Children's Hospital (BCH), Boston Medical Center (BMC), Brigham & Women's Hospital (BWH), Dartmouth Hitchcock Medical Center (DHMC), Massachusetts General Hospital (MGH), UMass Memorial Medical Center (UMMMC), and University of Vermont Medical Center (UVM). The team will continue to function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Specific Aims include: Aim 1: To continue to manage an administrative Hub for the SIREN Clinical Trials Network at Massachusetts General Hospital (MGH). We will continue to coordinate activities with the CCC, our Hub, and Spokes, including attendance at SIREN investigator meetings. Aim 2. To continue to support enrollment in ICECAP at MGH, Yale-New Haven Hospital, and Beth Israel Deaconess Medical Center. We will work to launch Brigham & Women's Hospital as an ICECAP site over the next 6 months. We will work to support enrollment in the Pediatric ICECAP trial and are working with both MGH and Yale-New Haven Hospital to prepare for participation and study launch. Aim 3. To continue to support enrollment in BOOST-3 at MGH, Yale-New Haven Hospital, UMass Medical Center, and Beth Israel Deaconess Medical Center. We will work to launch Brigham & Women's Hospital as a BOOST-3 site over the next 6 months. We will also support enrollment in the BOOST-3 ancillary trials Bio- BOOST and Electro-BOOST. Aim 4: To continue to support submission of novel trials. In coordination with the SIREN CCC, two of our Mass-SIREN investigators are working to submit the KESETT (Ketamine for Status Epilepticus) trial for funding.

项目摘要/摘要： 该应用程序将继续支持新英格兰的网络临床中心（HUB） 创新急诊临床试验网络（Siren）的策略。我们建议继续我们的 具有急诊室专业知识的大容量大三级护理医疗中心的综合合作团队 临床研究。我们的核心机构包括波士顿的贝丝以色列执事医疗中心（BIDMC） 达特茅斯的儿童医院（BCH），波士顿医疗中心（BMC），杨百翰及妇女医院（BWH） 马萨诸塞州综合医院（MGH）的希区柯克医疗中心（DHMC），UMASS纪念医疗中心 （UMMMC）和佛蒙特大学医学中心（UVM）。团队将继续运作 在行政上是一个枢纽和讲话模型，但在运营上是医疗中心的协作团队。 具体目的包括： 目的1：继续管理警笛临床试验网络的管理中心 马萨诸塞州综合医院（MGH）。我们将继续与CCC，我们的枢纽和 发言人，包括参加警笛调查员会议。 目标2。继续支持在MGH，耶鲁 - 新避风港医院和贝丝以色列的ICECAP入学 执事医疗中心。我们将努力将杨百翰及妇女医院作为冰科上的网站 接下来的6个月。我们将努力支持入学iCecap试验，并正在与两者一起工作 MGH和Yale-New Haven Hospital为参与和学习发布做准备。 目标3。继续支持在UMass Medical MGH的MGH的BOOST 3入学 中心和贝丝以色列执事医疗中心。我们将努力成立杨百翰妇女医院 在接下来的6个月内BOOST-3站点。我们还将支持参加BOOST 3辅助试验Bio-的注册 增强和电动增强。 目标4：继续支持提交新型试验。与警笛CCC协调，我们的两个 大众调查人员正在努力提交凯瑟特（氯胺酮癫痫持续肽）试验的试验 资金。