The Boston NETT Group

波士顿NETT集团

• 批准号: 8401565
• 负责人: Joshua N Goldstein
• 金额: $ 33.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8401565
• 关键词: Academic Medical Centers; Accident and Emergency department; Achievement; Acute; Adult; Area; Award; Boston; Caring; Cities; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Unit; Data Quality; Disease; Doctor of Philosophy; Emergency Medicine; Emergency Situation; Emergency treatment; Enrollment; Funding; General Hospitals; Hospitals; Human Resources; Institutes; Israel; Leadership; Massachusetts; Medical center; Meningitis; Morbidity - disease rate; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; Patient Care; Patients; Pediatric Hospitals; Performance; Population; Positioning Attribute; Principal Investigator; Protocols documentation; Provider; Recording of previous events; Records; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Seizures; Services; Site; Source; Spinal cord injury; Stroke; System; Therapy Clinical Trials; Time; Translational Research; Traumatic Brain Injury; Vision; Woman; acute stroke; catalyst; clinical research site; data management; design; disability; improved; innovation; meetings; metropolitan; mortality; nervous system disorder; programs; skills; success; trauma centers; treatment trial

DESCRIPTION (provided by applicant): We propose to create the Boston NETT Site, a team of hospitals and EMS agencies in Boston that will serve as a top-enrolling site and vibrant contributor to the NETT Network. Our group includes all adult Level I trauma centers in the city of Boston. All hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in both emergency and neurology departments, which can be leveraged to meet the needs of NETT. Principal investigator Joshua N. Goldstein, MD, PhD, and Co-investigator Jonathan Rosand, MD, MS bring a complementary set of skills in managing successful clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes investigators in neurology and emergency medicine with nationally recognized expertise managing the difficult task of enrolling patients in the emergency setting. Strengths of the Boston NETT Group include 1) the close personal and professional ties between multiple investigators, as shown by a history of successful collaborative research projects; 2) a large population from a major metropolitan area that spans the full range of neurologic disorders; 3) talented teams of site Investigators with track records of scientific achievement and innovation, as well as subject recruitment and data management in multicenter trials; 4) an existing research infrastructure, funded by a range of sources including NINDS, which can be leveraged to meet the needs of NETT; 5) numerous existing clinical research programs including the Neurology Clinical Trials Unit, The Harvard Catalyst Clinical and Translational Science Award (CTSA) program, the BU Clinical and Translational Science (CTSA) Institute, the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, the NeuroNEXT Network, and the NeuroNEXT Clinical Coordinating Center; 6) close integration with pre-hospital services, including Boston EMS and Boston Medflight. Overall, the Boston NETT Group has the resources, vision, and enthusiasm to enhance the ongoing success of the NETT Network. PUBLIC HEALTH RELEVANCE: The Boston NETT Site will be comprised of Massachusetts General Hospital (MGH), Brigham & Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), and Children's Hospital Boston (CHB), all organizations with internationally recognized patient care and clinical research programs.

描述（由申请人提供）：我们建议创建波士顿 NTT 网站，这是一个由波士顿医院和 EMS 机构组成的团队，将作为顶级注册网站和 NETT 网络的活跃贡献者。我们的团队包括波士顿市所有成人一级创伤中心。所有医院都拥有成功管理和临床试验绩效的良好记录。特别是，所有医院都拥有成熟的研究基础设施，可以在急诊科和神经科进行持续的临床研究，可以利用这些基础设施来满足 NTT 的需求。首席研究员 Joshua N. Goldstein（医学博士、哲学博士）和联合研究员 Jonathan Rosand（医学博士、理学硕士）在管理成功的临床研究项目、指导委员会成员以及各自领域的国家领导职位方面带来了一套互补的技能。我们的团队包括神经病学和急诊医学领域的研究人员，他们拥有全国公认的专业知识，能够处理在紧急情况下招募患者的艰巨任务。波士顿 NTT 集团的优势包括 1) 多名研究人员之间密切的个人和专业联系，正如成功的合作研究项目的历史所表明的那样； 2) 来自主要大都市区的大量人口，患有各种神经系统疾病； 3) 才华横溢的现场研究人员团队，拥有科学成就和创新记录，以及多中心试验中的受试者招募和数据管理； 4) 现有的研究基础设施，由包括 NINDS 在内的一系列来源资助，可用于满足 NetT 的需求； 5) 众多现有的临床研究项目，包括神经病学临床试验单位、哈佛催化剂临床和转化科学奖 (CTSA) 项目、BU 临床和转化科学 (CTSA) 研究所、急性中风转化研究专业项目 (SPOTRIAS)网络、NeuroNEXT 网络和 NeuroNEXT 临床协调中心； 6）与院前服务紧密结合，包括Boston EMS和Boston Medflight。总体而言，波士顿 NTT 集团拥有资源、愿景和热情来增强 NTT 网络的持续成功。 公共卫生相关性：波士顿 NTT 网站将由马萨诸塞州总医院 (MGH)、布莱根妇女医院 (BWH)、贝斯以色列女执事医疗中心 (BIDMC)、波士顿医疗中心 (BMC) 和波士顿儿童医院 (CHB) 组成，所有具有国际认可的患者护理和临床研究项目的组织。