The Mass-SIREN Group

Mass-SIRN 集团

• 批准号: 10197232
• 负责人: Joshua N Goldstein
• 金额: $ 16.76万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197232
• 关键词: Accident and Emergency department; Acute; Administrative Coordination; Area; Boston; Cardiology; Cardiopulmonary; Child; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; Data; Disease; Emergency Care; Emergency Department patient; Emergency Situation; Emergency research; Enrollment; Ensure; Funding; General Hospitals; Hematology; Hospitals; Individual; Infrastructure; International; Israel; Joints; Leadership; Massachusetts; Medical; Medical center; Medical emergency; Modeling; Neurologic; Neurology; New England; Operative Surgical Procedures; Patient Care; Patient Recruitments; Patients; Pediatric Hospitals; Performance; Positioning Attribute; Pre-hospital setting; Pre-hospitalization care; Protocol Compliance; Protocols documentation; Provider; Public Health; Publications; Pulmonology; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resources; Rural; Specialist; Training; Trauma; Trauma Research; Universities; Woman; acute care; clinical center; design; experience; flexibility; improved; innovation; medical specialties; member; novel; pragmatic trial; provider networks; rural setting; suburb; tertiary care; underserved minority

This application will create a Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose an integrated, collaborative team of high volume tertiary care medical centers with expertise in emergency care clinical research. The team includes an administrative Hub at Massachusetts General Hospital (MGH) with Spokes across the state including Baystate Medical Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham & Women's Hospital, UMass Memorial Medical Center, and St. Vincent Hospital. The Mass-SIREN Group will be managed by a Steering Committee including leaders from each of the member hospitals. It will function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Our team also includes nationally- and internationally-recognized leaders in neurology, cardiology, pulmonology, hematology, and trauma; we will propose novel ideas for the SIREN network, and innovative solutions to common problems in clinical trials including enrollment and retention. Specific Aims include: Aim 1: To establish an administrative Hub for the SIREN Clinical Trials Network at MGH. This Hub will enroll in each clinical trial. Additionally it will provide administrative coordination across the entire team. Aim 2. To establish the Mass-SIREN Steering Committee, an integrated leadership team that will coordinate trial management and enrollment across all of our centers. Aim 3. To provide our existing network of prehospital providers with the regulatory and educational infrastructure to ensure that trained EMS teams can successfully participate in SIREN clinical trials. Aim 4. To further establish the Mass-SIREN Steering Committee as innovative leaders in emergency care research. We will leverage our individual areas of expertise, our local co-investigators, and our colleagues with subspecialty expertise to design and propose innovative trials for the entire SIREN network. Our academic centers have experience conducting clinical emergency care research, and all have existing pools of trained clinical research coordinators that actively screen in the Emergency Department (ED) to manage enrollment and protocol compliance. Our hospitals see a wide range of patients, including children, underserved minorities, as well as those in urban, suburban, and rural settings. We include all major prehospital providers in Boston and across Massachusetts. Finally, this application highlights our long history of demonstrated interdisciplinary relationships, and that our team has a proven record of joint collaboration, trial performance, and scientific publication. Overall, the MASS-Siren Group includes both the breadth and depth of experience and resources to be an outstanding Network Clinical Center for SIREN.

该应用程序将为创新应急策略创建一个网络临床中心（中心） 护理临床试验网络 (SIREN)。我们建议建立一个由大量高等教育机构组成的综合协作团队 具有紧急护理临床研究专业知识的护理医疗中心。该团队包括行政人员 马萨诸塞州总医院 (MGH) 的中心，在全州范围内进行辐射，包括 Baystate Medical 中心、贝斯以色列女执事医疗中心、波士顿儿童医院、波士顿医疗中心、百翰医院 妇女医院、麻省大学纪念医疗中心和圣文森特医院。 Mass-SIRN 集团将 由各成员医院的领导组成的指导委员会管理。它将发挥作用 行政上采用中心辐射模型，但操作上采用医疗中心协作团队。我们的 团队还包括神经病学、心脏病学、肺病学、 血液学和创伤学；我们将为 SIREN 网络提出新颖的想法，并提出创新的解决方案 临床试验中的常见问题包括入组和保留。具体目标包括： 目标 1：在 MGH 建立 SIREN 临床试验网络的管理中心。该中心将 参加每个临床试验。此外，它将为整个团队提供行政协调。 目标 2. 建立 Mass-SIREN 指导委员会，这是一个综合领导团队，将 协调我们所有中心的试验管理和注册。 目标 3. 为我们现有的院前提供者网络提供监管和教育 确保训练有素的 EMS 团队能够成功参与 SIREN 临床试验的基础设施。 目标 4. 进一步建立 Mass-SIREN 指导委员会作为紧急情况下的创新领导者 护理研究。我们将利用我们各个领域的专业知识、当地的联合研究人员和同事 拥有专科专业知识，为整个 SIREN 网络设计和提出创新试验。 我们的学术中心拥有进行临床急救研究的经验，并且都拥有 现有的训练有素的临床研究协调员在急诊科 (ED) 中积极进行筛查 管理注册和协议合规性。我们的医院收治各种各样的患者，包括儿童、 服务不足的少数群体以及城市、郊区和农村地区的少数群体。我们包括所有主要 波士顿和马萨诸塞州各地的院前提供者。最后，这个应用程序凸显了我们悠久的历史 已证明的跨学科关系，并且我们的团队拥有良好的联合合作记录， 试验性能和科学发表。 总体而言，MASS-Siren 集团拥有广度和深度的经验和资源， SIREN 的杰出网络临床中心。