Urban rat exposure and pediatric asthma

城市老鼠暴露与小儿哮喘

• 批准号: 10723612
• 负责人: Marieke Hilarides Rosenbaum
• 金额: $ 16.67万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723612
• 关键词: Age; Allergens; Allergic; Allergic Disease; Asthma; Award; Binding; Binding Proteins; Boston; Child; Childhood; Childhood Asthma; Chronic Disease; Cities; Clinical Research; Clinical Trials; Collaborations; Commerce; Communities; Data; Disease; Doctor of Philosophy; Ecology; Enrollment; Environment; Environmental Health; Epidemiology; Exposure to; Faculty; Funding; Goals; Health; Home; Home environment; Hospitalization; House Dust; House mice; Housing; Human; IgE; Incidence; Individual; Institution; Intervention; Intervention Trial; Investigation; Learning; Measures; Mediating; Medical; Mentors; Modeling; Morbidity - disease rate; Mus; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Patient Self-Report; Pheromone; Play; Population Dynamics; Prevention Measures; Prevention strategy; Primary Prevention; Prospective cohort; Protein Secretion; Public Health; Rattus; Recording of previous events; Research; Resources; Restaurants; Rodent; Role; Sampling; Schools; Scientist; Services; Severities; Sleep; Statistical Methods; Techniques; Testing; Time; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Urine; Veterinarians; Veterinary Medicine; Visit; Wild Animals; Work; Youth; career; career development; clinical investigation; clinical translation; cohort; community engagement; data to knowledge; density; design; educational atmosphere; environmental allergen; indexing; inner city; interest; mouse allergen; novel; particle; preventive intervention; primary outcome; school environment; skills; sociodemographic variables; statistics; therapy design; trial design; urban children; urban school; urban setting

Project Summary/Abstract Research: Asthma is the most common chronic disease of children living in urban centers, and exposure to rat allergen can trigger asthma in children who are sensitized. The goal of this award is to evaluate the relationship between rat exposure and asthma severity in children using novel techniques to estimate rat exposure, including ecological studies of rat population dynamics and publicly available rat-related 311 complaint calls, around the home and school environment. Established cohorts of inner-city children enrolled in the School Inner-City Asthma Study (SICAS) and Environmental Assessment of Sleep in Youth (EASY) study (PI, Dr. Wanda Phipatanakul) will be used to study the impact of rat exposure on pediatric asthma severity. This study is unique and novel because it will be the first to evaluate the relationship between rat population dynamics on asthma severity. Results may lead to interventional trials designed to reduce commensal rodent abundance as a primary prevention measure to reduce exposure to the allergens they produce. Career Development: Dr. Marieke Rosenbaum is a veterinarian and public health scientist who seeks to integrate clinical research and veterinary medicine to design interventions that reduce the negative impact of urban peri-domestic wild animals on human health. Over the course of this award, Dr. Rosenbaum will gain important human clinical research skills, learn advanced statistics and modeling, and explore community engagement as the three pillars of her K08 training program. The proposed research and Dr. Rosenbaum’s career trajectory closely align with NIEHS 2018-2023 strategic themes 1 (Advance Environmental Health Science) and 2 (Promoting Translation – Data to Knowledge to Action) by opening a new line of transdisciplinary investigation about the urban environment, rat exposure, and pediatric asthma. Environment: Dr. Rosenbaum will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. Her team of advisors include Jon Runstadler (DVM, PhD), Jessica Leibler (DrPH, MS), and Janis Breeze (MPH), who together with the primary mentor have committed their time, resources, and expertise to facilitate Dr. Rosenbaum’s career development and successful completion of the proposed project. During this award period, Dr. Rosenbaum will complete course work and training at Tufts University, Boston University, and Harvard University, and she will be supported by the Tufts University Clinical Translational Science Institute, which offers career development training for junior faculty. The academic environment created by the mentor and institutions and their affiliates provides an optimal environment for learning and collaborating specific to the proposed research and training.

项目摘要/摘要 研究：哮喘是居住在城市中心的儿童最常见的慢性疾病，并且暴露于大鼠 过敏原可以引发敏感的儿童的哮喘。该奖项的目标是评估关系 使用新技术来估计大鼠暴露的儿童的大鼠暴露和哮喘的严重程度之间 大鼠种群动态和与大鼠公开相关的311个投诉电话的生态研究，围绕 家庭和学校环境。成立的城市内城市群体已入学 哮喘研究（SICAS）和青年睡眠的环境评估（轻松）研究（PI，Wanda博士 Phipatanakul）将用于研究大鼠暴露对小儿哮喘严重程度的影响。这项研究是独一无二的 和新颖 严重程度。结果可能会导致旨在减少共生啮齿动物丰度的介入试验 预防措施，以减少对产生的过敏原的暴露。 职业发展：玛丽克·罗森鲍姆（Marieke Rosenbaum）博士是一位兽医和公共卫生科学家 综合临床研究和兽医医学，以设计干预措施，以减少 城市围网野生动物在人类健康方面。在这个奖项的过程中，Rosenbaum博士将获得 重要的人类临床研究技能，学习高级统计和建模，并探索社区 订婚是她K08培训计划的三个支柱。拟议的研究和罗森鲍姆博士的 职业轨迹与NIEHS 2018-2023战略主题紧密保持一致1（预先环境健康 科学）和2（促进翻译 - 对知识的数据促进对行动的数据），通过打开新的跨学科系列 关于城市环境，大鼠暴露和小儿哮喘的调查。 环境：Rosenbaum博士将由流行病学专家Phipatanakul博士考虑，临床试验， 以及哮喘和过敏性疾病的临床研究。她的顾问团队包括Jon Runstadler（DVM， 博士学位），杰西卡·莱伯勒（DRPH，MS）和Janis Breeze（MPH），他们与主要导师一起 花时间，资源和专业知识来促进罗森鲍姆博士的职业发展和成功 拟议项目的完成。在此颁奖期间，Rosenbaum博士将完成课程工作，并且 在塔夫茨大学，波士顿大学和哈佛大学培训，她将得到塔夫茨的支持 大学临床转化科学研究所，为初级教师提供职业发展培训。这 精神和机构及其分支机构创造的学术环境提供了一个最佳的环境 针对拟议的研究和培训的学习和协作。