Neuroeconomics of Framing Effects and Risk Attitudes in Early Dementia

早期痴呆症的框架效应和风险态度的神经经济学

基本信息

批准号：
9288111
负责人：
Winston Chiong
金额：
$ 19.89万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9288111
关键词：
Affect Aging Alzheimer&apos s Disease Anterior Attitude Award Behavior Behavioral Biological Neural Networks Biometry Brain Brain imaging California Caregivers Caring Clinical Cognitive Data Decision Making Dementia Development Diagnostic Disease Early Diagnosis Economic Models Elderly Emotional Ethics Executive Dysfunction Family Frontotemporal Dementia Functional Magnetic Resonance Imaging Functional disorder Future Goals Impairment Insula of Reil Intervention Interview Investigation Judgment Legal Link Measures Mediating Medical Memory impairment Mentored Patient-Oriented Research Career Development Award Mentors Methods Modeling Neurologist Neuronal Dysfunction Neurosciences Outcome Pathologic Patients Pattern Policies Predisposition Prevention Process Public Health Research Rewards Risk Risk-Taking Role San Francisco Source Structure Symptoms Techniques Training Training Programs Universities Work aging population base behavior measurement behavioral neurology behavioral variant frontotemporal dementia career cingulate cortex executive function experience experimental study financial decision making financial exploitation improved informant insight neuroeconomics patient oriented research prevent programs public health relevance relating to nervous system response tool young adult

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Winston Chiong, a behavioral neurologist at the University of California, San Francisco. This K23 award will provide Dr. Chiong with the support necessary to accomplish the following goals: (1) to become expert at patient-oriented research in dementia; (2) to conduct behavioral and functional MRI investigations of decision-making in aging and in patients with Alzheimer's disease and frontotemporal dementia; (3) to characterize real-world decision-making errors in Alzheimer's disease and frontotemporal dementia using semi-structured informant interviews; (4) to apply tools and frameworks derived from neuroeconomics in interpreting patients' behaviors; (5) to apply new analytic techniques to functional MRI in dementia; and (6) to develop an independent research career. To achieve these goals, Dr. Chiong has assembled a mentoring team with two co-primary mentors. Dr. Howard Rosen is a behavioral neurologist who directs the UCSF State of California Alzheimer's Care Center and co-directs the UCSF Behavioral Neurology Training Program; and Dr. Mark D'Esposito is a behavioral neurologist and neuroscientist who directs the Henry H. Wheeler Jr. Brain Imaging Center at UC Berkeley. The mentoring team includes two collaborators: Dr. Joel Kramer, a neuropsychologist at UCSF with experience in measuring behavioral change in dementia; and Dr. Ming Hsu, a neuroeconomist at UC Berkeley with expertise in applying economic models to neural data. Finally, consultant Dr. John Neuhaus is a statistician who will assist in biostatistical analysis ad training. Financial decision-making errors can have disastrous consequences for patients and their families, and are among the earliest symptomatic indicators of dementia. Understanding the neural bases of these errors in dementia will therefore aid in early diagnosis, risk prediction harm prevention, and devising interventions to improve decision-making. Recent work in the neuroscience of decision-making provides a framework for understanding such errors in terms of decision-making biases, such as framing effects that distort financial judgment. Dr. Chiong's research will use a variety of techniques to study how decision-making biases and risk- taking are affected by aging and by Alzheimer's disease and frontotemporal dementia, two illnesses with very different effects on behavior and judgment. At a behavioral level, Dr. Chiong will use an established neuroeconomic task to assess framing effects and risk sensitivity in aging and in early disease. (Aim 1) At a neural level, he will use functional MRI to assess how large-scale neural network perturbations in these diseases affect financial decision-making. (Aim 2) And at a clinical level, he will use informant interviews within a neuroeconomic framework to characterize the financial decision-making errors that patients make in the real world. (Aim 3) These studies will advance our understanding of this important early symptom in dementia, setting the stage for future investigations of its significance in early diagnosis, and for behavioal and policy interventions to improve decision-making.

描述（由申请人提供）：这是加州大学旧金山分校行为神经学家 Winston Chiong 博士的 K23 奖项申请。该 K23 奖项将为钟博士提供实现以下目标所需的支持：(1) 成为以患者为导向的痴呆症研究专家； (2) 对衰老以及阿尔茨海默病和额颞叶痴呆患者的决策进行行为和功能 MRI 研究； (3) 使用半结构化知情人访谈来描述阿尔茨海默病和额颞叶痴呆的现实世界决策错误； (4) 应用源自神经经济学的工具和框架来解释患者的行为； (5) 将新的分析技术应用于痴呆症的功能磁共振成像； (6)发展独立的研究事业。为了实现这些目标，钟博士组建了一个由两名联合主要导师组成的导师团队。霍华德·罗森 (Howard Rosen) 博士是一名行为神经学家，负责指导 UCSF 加州阿尔茨海默病护理中心，并共同指导 UCSF 行为神经病学培训项目； Mark D'Esposito 博士是一位行为神经学家和神经科学家，负责加州大学伯克利分校 Henry H. Wheeler Jr. 脑成像中心的主任。指导团队包括两名合作者：Joel Kramer 博士，加州大学旧金山分校的神经心理学家，具有测量痴呆症行为变化的经验； Ming Hsu 博士是加州大学伯克利分校的神经经济学家，擅长将经济模型应用于神经数据。最后，顾问 John Neuhaus 博士是一位统计学家，他将协助生物统计分析和培训。财务决策错误可能会给患者及其家人带来灾难性后果，并且是痴呆症的最早症状指标之一。因此，了解痴呆症这些错误的神经基础将有助于早期诊断、风险预测、伤害预防以及制定干预措施以改善决策。决策神经科学的最新研究提供了一个框架，用于理解决策偏差方面的此类错误，例如扭曲财务判断的框架效应。钟博士的研究将使用多种技术来研究决策偏差和冒险行为如何受到衰老、阿尔茨海默病和额颞叶痴呆的影响，这两种疾病对行为和判断力的影响截然不同。在行为层面，钟博士将利用既定的神经经济学任务来评估衰老和早期疾病的框架效应和风险敏感性。（目标 1）在神经层面，他将使用功能 MRI 来评估这些疾病中的大规模神经网络扰动如何影响财务决策。（目标 2）在临床层面，他将在神经经济学框架内使用知情者访谈来描述患者在现实世界中犯下的财务决策错误。（目标 3）这些研究将增进我们对痴呆症这一重要早期症状的理解，为未来研究其在早期诊断中的重要性以及为改善决策的行为和政策干预奠定基础。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Response by Feldman et al to Letter Regarding Article, "Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014".

Feldman 等人对有关文章“1990-2014 年急性卒中试验招募率趋势”的信件的回复。

DOI：
发表时间：
2017-06
期刊：
影响因子：
8.3
作者：
Feldman, William B;Kim, Anthony S;Chiong, Winston
通讯作者：
Chiong, Winston

Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem.

制定适应性、个性化和可扩展的痴呆症护理计划：护理生态系统的早期发现。

DOI：
发表时间：
2017-03
期刊：
影响因子：
15.8
作者：
Possin, Katherine L;Merrilees, Jennifer;Bonasera, Stephen J;Bernstein, Alissa;Chiong, Winston;Lee, Kirby;Wilson, Leslie;Hooper, Sarah M;Dulaney, Sarah;Braley, Tamara;Laohavanich, Sutep;Feuer, Julie E;Clark, Amy M;Schaffer, Michael W;Schenk
通讯作者：
Schenk

Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014.

1990-2014 年急性卒中试验招募率趋势。