Cardiovascular Disease Epidemiology in Patients with Lupus

狼疮患者的心血管疾病流行病学

基本信息

批准号：
10612756
负责人：
Karen H Costenbader
金额：
$ 16.38万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612756
关键词：
Academic Training Adherence Adult Affect Antiphospholipid Antibodies Automobile Driving Azathioprine Biometry Biostatistical Methods Caring Cessation of life Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Collaborations Cyclophosphamide Data Data Sources Development Disease Outcome Dose Education Environment Epidemiology Ethnic Origin Event Evolution Familiarity Feedback Fostering Future General Population Glucocorticoids Grant Head Health Care Costs Heterogeneity Hospitals Immune Immunosuppressive Agents Individual Institution Knowledge Life Lupus Mediating Mediator Medicaid Medical Mentors Methods Modeling Modification Morbidity - disease rate Nephritis Onset of illness Outcome Outcome Study Outcomes Research Pathogenesis Patients Pharmaceutical Preparations Pharmacoepidemiology Phenotype Population Positioning Attribute Postdoctoral Fellow Productivity Publications Qualifying Race Regimen Research Research Personnel Research Project Grants Research Training Resources Rheumatism Rheumatoid Arthritis Risk Risk Factors Safety Scientist Severities Severity of illness Stroke Structural Models Systemic Lupus Erythematosus Testing Time Training Training Programs Variant Vulnerable Populations Woman Work cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk clinical practice cohort comorbidity comparative comparative safety disease heterogeneity epidemiology study ethnic disparity evidence based guidelines experience head-to-head comparison heart imaging high risk imaging modality improved mortality mycophenolate mofetil next generation novel participant enrollment patient oriented patient oriented research pre-doctoral preservation programs public health relevance racial disparity recruit research study rheumatologist risk prediction risk prediction model risk stratification skills sociodemographics success training opportunity translational study

项目摘要

PROJECT SUMMARY/ABSTRACT Dr. Karen Costenbader is a recognized patient-oriented investigator in the epidemiology and outcomes of systemic lupus erythematosus and rheumatoid arthritis, and a very engaged mentor of the next generation of patient-oriented clinical investigators. She has served as primary or secondary research mentor for 40 pre- and post-doctoral research trainees. Along with her position as Director of the Brigham and Women's Hospital Lupus Program, Dr. Costenbader's mentoring is facilitated by her affiliations with multiple Harvard-based institutions and training programs, and with national research and clinical organizations. The candidate's many ongoing patient-oriented research projects and collaborations, high degree of commitment to mentoring and to continuing to improve her mentoring skills, and the exceptional institutional resources, provide an outstanding environment for the development of junior investigators. This K24 grant would preserve Dr. Costenbader's protected time and relieve her of clinical and administrative responsibilities. The new research aims proposed will build upon past work on cardiovascular disease risk among lupus patients. With data on more than 100,000 lupus patients enrolled in Medicaid in the U.S., the new studies will address key unanswered questions about lupus disease heterogeneity and cardiovascular disease risk, with abundant statistical power to detect differences in these serious outcomes. The inherent sociodemographic variation of this population and the high risk of cardiovascular disease in this vulnerable population make these studies extremely relevant for improving care and outcomes for lupus patients. Additionally, validating and refining the 2017 QRISK3 cardiovascular disease risk prediction algorithm in the Brigham and Women's Lupus Cohort will provide patient interactions to collect and verify outcomes, and experience for mentees with developing risk prediction algorithms. The clinical questions to be examined will afford independent projects and publications, experience with advanced biostatistical models for research mentees, and excellent mentoring opportunities. Dr. Costenbader has assembled a strong team of highly qualified co-mentors and she will recruit two to three new trainees into her rheumatic disease epidemiology and outcomes research program annually. She will continue to refine her mentoring program and skills using trainee feedback and the many educational opportunities in her environment. This K24 grant would support Dr. Costenbader's ability to develop the next generation of patient-oriented rheumatic disease investigators.

项目摘要/摘要 Karen Costenbader博士是一名公认的以患者为导向的研究者全身性红斑狼疮和类风湿关节炎，以及下一代非常参与的导师面向患者的临床研究者。她曾担任40和二级研究导师的40位前和40位博士后研究学员。她担任杨百翰和妇女医院主任狼疮计划，Costenbader博士的指导是她与多个基于哈佛大学的隶属关系促进的机构和培训计划，以及国家研究和临床组织。候选人的众多正在进行的面向患者的研究项目和合作，对指导和对继续提高她的指导能力和卓越的机构资源，提供了出色的开发初级调查人员的环境。这项K24赠款将保留Costenbader博士保护时间，并减轻她的临床和行政责任。提出的新研究目的将基于狼疮患者的心血管疾病风险的过去工作。与超过的数据超过 100,000名狼疮患者在美国招收医疗补助，新研究将解决关键的未解决的关键有关狼疮疾病异质性和心血管疾病风险的问题，具有丰富的统计能力检测这些严重结果的差异。该人群和在这种脆弱人群中，心血管疾病的高风险使这些研究与改善狼疮患者的护理和结果。此外，验证和完善2017 Qrisk3 杨百翰和女性狼疮队列的心血管疾病风险预测算法将为患者提供互动以收集和验证成果，以及有发展风险预测的受训者的经验算法。待检查的临床问题将提供独立的项目和出版物，经验具有用于研究指导者的先进生物统计学模型，以及出色的指导机会。博士 Costenbader组装了一支由高素质的联盟组成的团队，她将招募两到三个新的学员每年都会进入她的风湿病流行病学和结果研究计划。她将继续使用学员的反馈以及许多教育机会来完善她的指导计划和技能她的环境。这项K24赠款将支持Costenbader博士发展下一代的能力面向患者的风湿病研究者。

项目成果

期刊论文数量（41）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development.

DOI：
10.3389/fimmu.2022.890522
发表时间：
2022
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
通讯作者：

Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration.

DOI：
10.1002/acr.23317
发表时间：
2018-04
期刊：
Arthritis care & research
影响因子：
4.7
作者：
Tedeschi SK;Johnson SR;Boumpas D;Daikh D;Dörner T;Jayne D;Kamen D;Lerstrøm K;Mosca M;Ramsey-Goldman R;Sinnette C;Wofsy D;Smolen JS;Naden RP;Aringer M;Costenbader KH
通讯作者：
Costenbader KH

Disease activity and transition outcomes in a childhood-onset systemic lupus erythematosus cohort.